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Items: 1 to 20 of 106

1.

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.

Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C.

Nat Cell Biol. 2000 Nov;2(11):848-51.

PMID:
11056541
2.

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.

J Cell Biol. 2002 Aug 5;158(3):551-61. Epub 2002 Jul 29.

3.

Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.

Steiner H, Winkler E, Shearman MS, Prywes R, Haass C.

Neurobiol Dis. 2001 Aug;8(4):717-22.

PMID:
11493036
5.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

6.

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA.

Nat Cell Biol. 2000 Jul;2(7):463-5. No abstract available.

PMID:
10878814
7.
8.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.

9.

Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.

Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.

Mol Vis. 2003 May 1;9:179-83.

10.

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.

J Neurochem. 2005 Nov;95(3):880-90. Epub 2005 Aug 31.

11.

gamma-Secretase inhibitors as molecular probes of presenilin function.

Wolfe MS.

J Mol Neurosci. 2001 Oct;17(2):199-204. Review.

PMID:
11816793
12.

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.

Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y.

Biochemistry. 2003 Feb 4;42(4):1042-52.

PMID:
12549925
13.

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM.

J Biol Chem. 2003 Jun 20;278(25):22475-81. Epub 2003 Apr 8.

14.

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P.

Nature. 2000 Sep 7;407(6800):48-54.

PMID:
10993067
15.

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.

Kulic L, Walter J, Multhaup G, Teplow DB, Baumeister R, Romig H, Capell A, Steiner H, Haass C.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5913-8.

16.

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

Selkoe DJ.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. Review.

17.

Secretase as a target for Alzheimer's disease.

Wolfe MS.

Curr Top Med Chem. 2002 Apr;2(4):371-83. Review.

PMID:
11966461
18.

[Beta-amyloid protein: recent progress in basic research and therapeutic approaches].

Iwatsubo T.

Rinsho Shinkeigaku. 2001 Dec;41(12):1198-200. Review. Japanese.

PMID:
12235837
19.

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling.

Levitan D, Lee J, Song L, Manning R, Wong G, Parker E, Zhang L.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12186-90. Epub 2001 Oct 2.

20.

Presenilin function and gamma-secretase activity.

Brunkan AL, Goate AM.

J Neurochem. 2005 May;93(4):769-92. Review.

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