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p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM.

J Biol Chem. 2000 Dec 29;275(52):41201-9.


Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM.

J Biol Chem. 2000 Jun 16;275(24):18108-13.


A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

Bokoch GM, Reilly AM, Daniels RH, King CC, Olivera A, Spiegel S, Knaus UG.

J Biol Chem. 1998 Apr 3;273(14):8137-44.


Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression.

Görlach A, BelAiba RS, Hess J, Kietzmann T.

Thromb Haemost. 2005 Jun;93(6):1168-75.


3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.


Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.

J Biol Chem. 1999 Dec 24;274(52):37400-6.


Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.

Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y, Liu F.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5089-94.


PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR.

Curr Biol. 1999 Apr 22;9(8):393-404.


Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.

Edwards DC, Sanders LC, Bokoch GM, Gill GN.

Nat Cell Biol. 1999 Sep;1(5):253-9.


3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.

Curr Biol. 1997 Oct 1;7(10):776-89.


Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration.

Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J.

Mol Cell Biol. 2003 Nov;23(22):8058-69.


Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis.

Zegzouti H, Anthony RG, Jahchan N, Bögre L, Christensen SK.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6404-9. Epub 2006 Apr 6.


Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.

Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM.

J Biol Chem. 2005 Jan 21;280(3):2055-64. Epub 2004 Nov 12.


Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells.

Jung ID, Lee J, Lee KB, Park CG, Kim YK, Seo DW, Park D, Lee HW, Han JW, Lee HY.

Eur J Biochem. 2004 Apr;271(8):1557-65.


Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes.

Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q.

J Mol Cell Cardiol. 2008 Feb;44(2):429-34. Epub 2007 Dec 3.


RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.

Kim DW, Hwang JH, Suh JM, Kim H, Song JH, Hwang ES, Hwang IY, Park KC, Chung HK, Kim JM, Park J, Hemmings BA, Shong M.

Mol Endocrinol. 2003 Jul;17(7):1382-94. Epub 2003 May 8.


Phosphorylation and activation of p70s6k by PDK1.

Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.

Science. 1998 Jan 30;279(5351):707-10.


A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

Frödin M, Jensen CJ, Merienne K, Gammeltoft S.

EMBO J. 2000 Jun 15;19(12):2924-34.

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