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Items: 1 to 20 of 293

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Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: synthesis and stability of N-acylamino acid derivatives of triazenes.

Perry Mde J, Carvalho E, Rosa E, Iley J.

Eur J Med Chem. 2009 Mar;44(3):1049-56. doi: 10.1016/j.ejmech.2008.06.022. Epub 2008 Jun 28.

PMID:
18687506
5.

Triazene metabolism. VI. 3-Azidomethyl-3-alkyl-1-aryltriazenes, a new class of anti-tumour triazene with potential pro-drug applications.

Vaughan K, Nicholas G, Singer RD, Roy M, Gibson NW.

Anticancer Drug Des. 1987 Dec;2(3):279-87.

PMID:
3449091
6.

Isosorbide-based aspirin prodrugs. II. Hydrolysis kinetics of isosorbide diaspirinate.

Gilmer JF, Moriarty LM, Lally MN, Clancy JM.

Eur J Pharm Sci. 2002 Sep;16(4-5):297-304.

PMID:
12208460
7.

Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines.

Monteiro AS, Almeida J, Cabral G, Severino P, Videira PA, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E.

Eur J Med Chem. 2013;70:1-9. doi: 10.1016/j.ejmech.2013.09.040. Epub 2013 Oct 2.

PMID:
24125877
8.

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

Perry MJ, Mendes E, Simplício AL, Coelho A, Soares RV, Iley J, Moreira R, Francisco AP.

Eur J Med Chem. 2009 Aug;44(8):3228-34. doi: 10.1016/j.ejmech.2009.03.025. Epub 2009 Mar 27.

PMID:
19386398
11.

New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.

Vlieghe P, Bihel F, Clerc T, Pannecouque C, Witvrouw M, De Clercq E, Salles JP, Chermann JC, Kraus JL.

J Med Chem. 2001 Mar 1;44(5):777-86.

PMID:
11262088
13.

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design.

Rodrigues T, Moreira R, Guedes RC, Iley J, Lopes F.

Arch Pharm (Weinheim). 2008 Jun;341(6):344-50. doi: 10.1002/ardp.200700250.

PMID:
18442019
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A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation.

Mata G, do Rosário VE, Iley J, Constantino L, Moreira R.

Bioorg Med Chem. 2012 Jan 15;20(2):886-92. doi: 10.1016/j.bmc.2011.11.059. Epub 2011 Dec 3.

PMID:
22189276
16.

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.

Ribeiro L, Silva N, Iley J, Rautio J, Järvinen T, Mota-Filipe H, Moreira R, Mendes E.

Arch Pharm (Weinheim). 2007 Jan;340(1):32-40.

PMID:
17206608
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Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity.

Redden PR, Melanson RL, Douglas JA, Dick AJ.

Int J Pharm. 1999 Apr 15;180(2):151-60.

PMID:
10370185

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