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The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.

Zheng L, Sekerková G, Vranich K, Tilney LG, Mugnaini E, Bartles JR.

Cell. 2000 Aug 4;102(3):377-85.


Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice.

Sekerková G, Richter CP, Bartles JR.

PLoS Genet. 2011 Mar;7(3):e1002032. doi: 10.1371/journal.pgen.1002032. Epub 2011 Mar 24.


Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli.

Sekerková G, Zheng L, Loomis PA, Mugnaini E, Bartles JR.

Cell Mol Life Sci. 2006 Oct;63(19-20):2329-41. Review.


Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear.

Li H, Liu H, Balt S, Mann S, Corrales CE, Heller S.

J Comp Neurol. 2004 Jan 1;468(1):125-34.


Espin gene (ESPN) mutations associated with autosomal dominant hearing loss cause defects in microvillar elongation or organisation.

Donaudy F, Zheng L, Ficarella R, Ballana E, Carella M, Melchionda S, Estivill X, Bartles JR, Gasparini P.

J Med Genet. 2006 Feb;43(2):157-61. Epub 2005 Jun 1.


Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells.

Loomis PA, Kelly AE, Zheng L, Changyaleket B, Sekerková G, Mugnaini E, Ferreira A, Mullins RD, Bartles JR.

J Cell Sci. 2006 Apr 15;119(Pt 8):1655-65. Epub 2006 Mar 28.


Genetic and physical maps of jerker (Espn(je)) on mouse chromosome 4.

Jackson T, Thomas J, Green ED, Noben-Trauth K.

Biochem Biophys Res Commun. 2002 Sep 6;296(5):1143-7.


Balanced levels of Espin are critical for stereociliary growth and length maintenance.

Rzadzinska A, Schneider M, Noben-Trauth K, Bartles JR, Kachar B.

Cell Motil Cytoskeleton. 2005 Nov;62(3):157-65.


Mutations of ESPN cause autosomal recessive deafness and vestibular dysfunction.

Naz S, Griffith AJ, Riazuddin S, Hampton LL, Battey JF Jr, Khan SN, Riazuddin S, Wilcox ER, Friedman TB.

J Med Genet. 2004 Aug;41(8):591-5.


Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells.

Sekerková G, Zheng L, Loomis PA, Changyaleket B, Whitlon DS, Mugnaini E, Bartles JR.

J Neurosci. 2004 Jun 9;24(23):5445-56.


Whirlin interacts with espin and modulates its actin-regulatory function: an insight into the mechanism of Usher syndrome type II.

Wang L, Zou J, Shen Z, Song E, Yang J.

Hum Mol Genet. 2012 Feb 1;21(3):692-710. doi: 10.1093/hmg/ddr503. Epub 2011 Nov 2.


Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.

Bartles JR, Zheng L, Li A, Wierda A, Chen B.

J Cell Biol. 1998 Oct 5;143(1):107-19.


Genetically induced inner ear degeneration. A structural and functional study.

Sjöström B, Anniko M.

Acta Otolaryngol Suppl. 1992;493:141-6.


Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.

Loomis PA, Zheng L, Sekerková G, Changyaleket B, Mugnaini E, Bartles JR.

J Cell Biol. 2003 Dec 8;163(5):1045-55. Epub 2003 Dec 1.


Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin.

Zheng L, Beeler DM, Bartles JR.

J Cell Sci. 2014 Mar 15;127(Pt 6):1306-17. doi: 10.1242/jcs.143255. Epub 2014 Jan 14. Erratum in: J Cell Sci. 2015 Jun 1;128(11):2208.


Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.

Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A, Petit C.

J Cell Biol. 2016 Jan 18;212(2):231-44. doi: 10.1083/jcb.201509017. Epub 2016 Jan 11.


Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia.

Purdy KR, Bartles JR, Wong GC.

Phys Rev Lett. 2007 Feb 2;98(5):058105. Epub 2007 Feb 1.


Espin actin-cytoskeletal proteins are in rat type I spiral ganglion neurons and include splice-isoforms with a functional nuclear localization signal.

Sekerková G, Zheng L, Mugnaini E, Bartles JR.

J Comp Neurol. 2008 Aug 20;509(6):661-76. doi: 10.1002/cne.21755.

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