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Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.

Chau BN, Cheng EH, Kerr DA, Hardwick JM.

Mol Cell. 2000 Jul;6(1):31-40.


Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death.

Inohara N, Gourley TS, Carrio R, Muñiz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Núñez G.

J Biol Chem. 1998 Dec 4;273(49):32479-86.


Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions.

Figueroa B Jr, Chen S, Oyler GA, Hardwick JM, Betenbaugh MJ.

Biotechnol Bioeng. 2004 Mar 20;85(6):589-600.


Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.

Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z, Alnemri ES.

J Biol Chem. 2000 Nov 17;275(46):36152-7.


Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.

Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 1998 Apr 3;273(14):7783-6.


Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death.

Cao G, Xiao M, Sun F, Xiao X, Pei W, Li J, Graham SH, Simon RP, Chen J.

J Neurosci. 2004 Jul 7;24(27):6189-201.


Bcl-xL does not inhibit the function of Apaf-1.

Newmeyer DD, Bossy-Wetzel E, Kluck RM, Wolf BB, Beere HM, Green DR.

Cell Death Differ. 2000 Apr;7(4):402-7.


Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.

Hasenjäger A, Gillissen B, Müller A, Normand G, Hemmati PG, Schuler M, Dörken B, Daniel PT.

Oncogene. 2004 Jun 3;23(26):4523-35.


Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex.

Pan G, O'Rourke K, Dixit VM.

J Biol Chem. 1998 Mar 6;273(10):5841-5.


XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.

Bratton SB, Lewis J, Butterworth M, Duckett CS, Cohen GM.

Cell Death Differ. 2002 Sep;9(9):881-92.


Caspase-9 is activated in a cytochrome c-independent manner early during TNFalpha-induced apoptosis in murine cells.

McDonnell MA, Wang D, Khan SM, Vander Heiden MG, Kelekar A.

Cell Death Differ. 2003 Sep;10(9):1005-15.


Apaf-1 is a mediator of E2F-1-induced apoptosis.

Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M.

J Biol Chem. 2002 Oct 18;277(42):39760-8. Epub 2002 Jul 30.


Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL.

Kutuk O, Temel SG, Tolunay S, Basaga H.

Eur J Cancer. 2010 Sep;46(13):2494-505. doi: 10.1016/j.ejca.2010.06.011. Epub 2010 Jul 7.


LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway.

Deng W, Wang DA, Gosmanova E, Johnson LR, Tigyi G.

Am J Physiol Gastrointest Liver Physiol. 2003 May;284(5):G821-9.


Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.

Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC.

J Biol Chem. 2004 Nov 12;279(46):48168-76. Epub 2004 Aug 27.


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