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Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase.

Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, Altman Y, Fang D, Hunter T, Liu YC.

J Biol Chem. 2000 Nov 17;275(46):35734-7.


The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch.

Traweger A, Fang D, Liu YC, Stelzhammer W, Krizbai IA, Fresser F, Bauer HC, Bauer H.

J Biol Chem. 2002 Mar 22;277(12):10201-8. Epub 2002 Jan 8.


The E3 ligase Itch in immune regulation and beyond.

Aki D, Zhang W, Liu YC.

Immunol Rev. 2015 Jul;266(1):6-26. doi: 10.1111/imr.12301. Review.


Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.

Riling C, Kamadurai H, Kumar S, O'Leary CE, Wu KP, Manion EE, Ying M, Schulman BA, Oliver PM.

J Biol Chem. 2015 Sep 25;290(39):23875-87. doi: 10.1074/jbc.M115.649269. Epub 2015 Aug 5.


Functional domains of the Rsp5 ubiquitin-protein ligase.

Wang G, Yang J, Huibregtse JM.

Mol Cell Biol. 1999 Jan;19(1):342-52.


Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.

Kumar S, Kao WH, Howley PM.

J Biol Chem. 1997 May 23;272(21):13548-54.


A HECT domain E3 enzyme assembles novel polyubiquitin chains.

You J, Pickart CM.

J Biol Chem. 2001 Jun 8;276(23):19871-8. Epub 2001 Mar 14.


Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.

Schwarz SE, Rosa JL, Scheffner M.

J Biol Chem. 1998 May 15;273(20):12148-54.


Interaction between syntaxin 8 and HECTd3, a HECT domain ligase.

Zhang L, Kang L, Bond W, Zhang N.

Cell Mol Neurobiol. 2009 Feb;29(1):115-21. doi: 10.1007/s10571-008-9303-0. Epub 2008 Sep 27.


HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.

ZeRuth GT, Williams JG, Cole YC, Jetten AM.

PLoS One. 2015 Jul 6;10(7):e0131303. doi: 10.1371/journal.pone.0131303. eCollection 2015.


Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

Courbard JR, Fiore F, Adélaïde J, Borg JP, Birnbaum D, Ollendorff V.

J Biol Chem. 2002 Nov 22;277(47):45267-75. Epub 2002 Sep 10.


HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.

Ishihara T, Inoue J, Kozaki K, Imoto I, Inazawa J.

J Biol Chem. 2011 Dec 23;286(51):44086-94. doi: 10.1074/jbc.M111.251694. Epub 2011 Oct 18.


The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA.

J Biol Chem. 2003 Jun 13;278(24):21930-7. Epub 2003 Apr 1.


Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.

McGill MA, McGlade CJ.

J Biol Chem. 2003 Jun 20;278(25):23196-203. Epub 2003 Apr 7.


p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch.

Melino S, Bellomaria A, Nepravishta R, Paci M, Melino G.

Cell Cycle. 2014;13(20):3207-17. doi: 10.4161/15384101.2014.951285.


Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases.

Rotin D, Staub O, Haguenauer-Tsapis R.

J Membr Biol. 2000 Jul 1;176(1):1-17. Review.


Itchy mice: the identification of a new pathway for the development of autoimmunity.

Matesic LE, Copeland NG, Jenkins NA.

Curr Top Microbiol Immunol. 2008;321:185-200. Review.


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