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Items: 1 to 20 of 163

1.
2.

BACE is degraded via the lysosomal pathway.

Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G.

J Biol Chem. 2005 Sep 16;280(37):32499-504. Epub 2005 Jul 20.

3.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

4.

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.

Kinoshita A, Fukumoto H, Shah T, Whelan CM, Irizarry MC, Hyman BT.

J Cell Sci. 2003 Aug 15;116(Pt 16):3339-46. Epub 2003 Jun 26.

5.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94. Epub 2003 Mar 27.

7.

Maturation and pro-peptide cleavage of beta-secretase.

Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2000 Oct 6;275(40):30849-54.

8.

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.

Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M.

J Biol Chem. 2000 Jul 14;275(28):21099-106.

9.

Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.

Huse JT, Byant D, Yang Y, Pijak DS, D'Souza I, Lah JJ, Lee VM, Doms RW, Cook DG.

J Biol Chem. 2003 May 9;278(19):17141-9. Epub 2003 Jan 27.

10.

Phosphorylation regulates intracellular trafficking of beta-secretase.

Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2001 May 4;276(18):14634-41. Epub 2001 Jan 29.

11.

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)).

Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y.

J Biol Chem. 2003 Apr 25;278(17):15239-45. Epub 2003 Feb 13.

12.
13.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT.

J Neurosci. 2006 Jan 11;26(2):418-28.

14.

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.

Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C.

J Biol Chem. 2004 Dec 17;279(51):53205-12. Epub 2004 Oct 12.

15.

A non-amyloidogenic function of BACE-2 in the secretory pathway.

Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J.

J Neurochem. 2002 Jun;81(5):1011-20.

16.

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.

Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R.

J Biol Chem. 2000 Dec 1;275(48):37712-7. Erratum in: J Biol Chem 2001 May 4;276(18):15561.

17.
19.

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

Sauder JM, Arthur JW, Dunbrack RL Jr.

J Mol Biol. 2000 Jul 7;300(2):241-8.

PMID:
10873463
20.

Human BACE forms dimers and colocalizes with APP.

Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G.

J Biol Chem. 2004 Sep 17;279(38):39710-7. Epub 2004 Jul 9.

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