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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K.

Mol Cell. 2000 Apr;5(4):649-58.


Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.

Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N.

Mol Cell Biol. 2002 Feb;22(4):992-1000.


Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.

Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K.

EMBO J. 2003 Dec 1;22(23):6277-88.


IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.

Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X.

J Biol Chem. 2001 Nov 9;276(45):41661-7. Epub 2001 Aug 22.


TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.

Morlon A, Munnich A, Smahi A.

Hum Mol Genet. 2005 Dec 1;14(23):3751-7. Epub 2005 Oct 26.


Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.

Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K.

Mol Cell Biol. 2001 Apr;21(7):2475-84.


ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.

Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H.

J Biol Chem. 2000 Oct 20;275(42):32747-52.


WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.

Gao D, Wang R, Li B, Yang Y, Zhai Z, Chen DY.

Cell Mol Life Sci. 2009 Aug;66(15):2573-84. doi: 10.1007/s00018-009-0059-6. Epub 2009 Jun 12.


Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .

Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X.

J Biol Chem. 2003 May 9;278(19):16713-9. Epub 2003 Feb 27. Erratum in: J Biol Chem. 2003 Jun 20;278(5):23212.


The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.

Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K.

Nature. 1999 Mar 18;398(6724):252-6.


TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.

Lee SW, Han SI, Kim HH, Lee ZH.

J Biochem Mol Biol. 2002 Jul 31;35(4):371-6.


TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.

Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.

Mol Cell Biol. 2003 Feb;23(4):1231-8.


The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation.

Holtmann H, Enninga J, Kalble S, Thiefes A, Dorrie A, Broemer M, Winzen R, Wilhelm A, Ninomiya-Tsuji J, Matsumoto K, Resch K, Kracht M.

J Biol Chem. 2001 Feb 2;276(5):3508-16. Epub 2000 Oct 24.


Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.

Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY.

Cell Signal. 2015 Dec;27(12):2524-33. doi: 10.1016/j.cellsig.2015.09.018. Epub 2015 Sep 30.


T6BP, a TRAF6-interacting protein involved in IL-1 signaling.

Ling L, Goeddel DV.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72.


Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.

Shi L, Zhang Z, Fang S, Xu J, Liu J, Shen J, Fang F, Luo L, Yin Z.

Mol Immunol. 2009 Feb;46(4):541-50. doi: 10.1016/j.molimm.2008.07.019. Epub 2008 Oct 31.


TAB3, a new binding partner of the protein kinase TAK1.

Cheung PC, Nebreda AR, Cohen P.

Biochem J. 2004 Feb 15;378(Pt 1):27-34.


TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.

Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S.

Genes Dev. 2005 Nov 15;19(22):2668-81. Epub 2005 Oct 31.


Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

Jiang Z, Mak TW, Sen G, Li X.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3533-8. Epub 2004 Feb 24.

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