Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 191


PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR.

Cell. 2000 May 12;101(4):365-76.


Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death.

Marks AR.

J Mol Cell Cardiol. 2001 Apr;33(4):615-24. Review.


Immunophilins and coupled gating of ryanodine receptors.

Lehnart SE, Huang F, Marx SO, Marks AR.

Curr Top Med Chem. 2003;3(12):1383-91. Review.


Regulation of the ryanodine receptor in heart failure.

Marx SO, Marks AR.

Basic Res Cardiol. 2002;97 Suppl 1:I49-51. Review.


Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol.

Reiken S, Gaburjakova M, Guatimosim S, Gomez AM, D'Armiento J, Burkhoff D, Wang J, Vassort G, Lederer WJ, Marks AR.

J Biol Chem. 2003 Jan 3;278(1):444-53. Epub 2002 Oct 24.


Ryanodine receptors, FKBP12, and heart failure.

Marks AR.

Front Biosci. 2002 Apr 1;7:d970-7. Review.


Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR.

Circulation. 2003 May 20;107(19):2459-66. Epub 2003 May 12.


FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure.

Yano M, Kobayashi S, Kohno M, Doi M, Tokuhisa T, Okuda S, Suetsugu M, Hisaoka T, Obayashi M, Ohkusa T, Kohno M, Matsuzaki M.

Circulation. 2003 Jan 28;107(3):477-84.


Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR.

Circulation. 2005 Apr 26;111(16):2025-32.


Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM.

Circ Res. 2005 Dec 9;97(12):1314-22. Epub 2005 Nov 3.


Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

Xiao B, Jiang MT, Zhao M, Yang D, Sutherland C, Lai FA, Walsh MP, Warltier DC, Cheng H, Chen SR.

Circ Res. 2005 Apr 29;96(8):847-55. Epub 2005 Mar 24.


beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure.

Reiken S, Gaburjakova M, Gaburjakova J, He Kl KL, Prieto A, Becker E, Yi Gh GH, Wang J, Burkhoff D, Marks AR.

Circulation. 2001 Dec 4;104(23):2843-8.


Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure.

Jiang MT, Lokuta AJ, Farrell EF, Wolff MR, Haworth RA, Valdivia HH.

Circ Res. 2002 Nov 29;91(11):1015-22.


Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor.

Doi M, Yano M, Kobayashi S, Kohno M, Tokuhisa T, Okuda S, Suetsugu M, Hisamatsu Y, Ohkusa T, Kohno M, Matsuzaki M.

Circulation. 2002 Mar 19;105(11):1374-9.


Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak.

Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR.

Circulation. 2004 Jun 29;109(25):3208-14. Epub 2004 Jun 14.


Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers.

Marks AR, Marx SO, Reiken S.

Trends Cardiovasc Med. 2002 May;12(4):166-70. Review.


Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.

Xiao B, Tian X, Xie W, Jones PP, Cai S, Wang X, Jiang D, Kong H, Zhang L, Chen K, Walsh MP, Cheng H, Chen SR.

J Biol Chem. 2007 Oct 12;282(41):30256-64. Epub 2007 Aug 10.


Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor.

Xin HB, Rogers K, Qi Y, Kanematsu T, Fleischer S.

J Biol Chem. 1999 May 28;274(22):15315-9.


Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor.

Benkusky NA, Weber CS, Scherman JA, Farrell EF, Hacker TA, John MC, Powers PA, Valdivia HH.

Circ Res. 2007 Oct 12;101(8):819-29. Epub 2007 Aug 23.

Supplemental Content

Support Center