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In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.

Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Weichselbaum RR.

Clin Cancer Res. 2000 Feb;6(2):737-42.


Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines.

Hoffmann TK, Leenen K, Hafner D, Balz V, Gerharz CD, Grund A, Balló H, Hauser U, Bier H.

Anticancer Drugs. 2002 Jan;13(1):93-100.


Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.

Chmura SJ, Mauceri HJ, Advani S, Heimann R, Beckett MA, Nodzenski E, Quintans J, Kufe DW, Weichselbaum RR.

Cancer Res. 1997 Oct 1;57(19):4340-7.


Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.

Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR.

Cancer Res. 2006 Jun 15;66(12):6296-303.


betaII protein kinase C is required for the G2/M phase transition of cell cycle.

Thompson LJ, Fields AP.

J Biol Chem. 1996 Jun 21;271(25):15045-53.


Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.

Lee SK, Qing WG, Mar W, Luyengi L, Mehta RG, Kawanishi K, Fong HH, Beecher CW, Kinghorn AD, Pezzuto JM.

J Biol Chem. 1998 Jul 31;273(31):19829-33.


Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors.

Zweifel BS, Davis TW, Ornberg RL, Masferrer JL.

Cancer Res. 2002 Nov 15;62(22):6706-11.


Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.

Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, Gutkind JS.

Cancer Res. 2005 Nov 1;65(21):9953-61.


Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.

Yamamoto S, Seta K, Morisco C, Vatner SF, Sadoshima J.

J Mol Cell Cardiol. 2001 Oct;33(10):1829-48.


Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.

Dean N, McKay R, Miraglia L, Howard R, Cooper S, Giddings J, Nicklin P, Meister L, Ziel R, Geiger T, Muller M, Fabbro D.

Cancer Res. 1996 Aug 1;56(15):3499-507.


Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells.

Mantha AJ, McFee KE, Niknejad N, Goss G, Lorimer IA, Dimitroulakos J.

J Cancer Res Clin Oncol. 2003 Nov;129(11):631-41.


Effects of tamoxifen on human squamous cell carcinoma lines of the head and neck.

Hoffmann TK, Bojar H, Eckel J, van Lierop A, Balz V, Friebe-Hoffmann U, Hauser U, Bier H.

Anticancer Drugs. 2002 Jun;13(5):521-31.


Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38.

Thomas SM, Zeng Q, Epperly MW, Gooding WE, Pastan I, Wang QC, Greenberger J, Grandis JR.

Clin Cancer Res. 2004 Oct 15;10(20):7079-87.


Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells.

Sun SY, Yue P, Mao L, Dawson MI, Shroot B, Lamph WW, Heyman RA, Chandraratna RA, Shudo K, Hong WK, Lotan R.

Clin Cancer Res. 2000 Apr;6(4):1563-73.


Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts.

Vink SR, Lagerwerf S, Mesman E, Schellens JH, Begg AC, van Blitterswijk WJ, Verheij M.

Clin Cancer Res. 2006 Mar 1;12(5):1615-22.


P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.

Joshi KS, Rathos MJ, Mahajan P, Wagh V, Shenoy S, Bhatia D, Chile S, Sivakumar M, Maier A, Fiebig HH, Sharma S.

Mol Cancer Ther. 2007 Mar;6(3):926-34.


Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.

Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB.

Clin Cancer Res. 2008 Oct 1;14(19):6228-36. doi: 10.1158/1078-0432.CCR-07-5177.


Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma.

Yin X, Hayes DN, Shores CG.

Head Neck. 2011 Aug;33(8):1106-14. doi: 10.1002/hed.21578.

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