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Items: 1 to 20 of 174

1.

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.

Humbert S, Dhavan R, Tsai L.

J Cell Sci. 2000 Mar;113 ( Pt 6):975-83.

2.

Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.

Johansson JU, Lilja L, Chen XL, Higashida H, Meister B, Noda M, Zhong ZG, Yokoyama S, Berggren PO, Bark C.

Brain Res Mol Brain Res. 2005 Aug 18;138(2):215-27.

PMID:
15908038
3.

Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia.

Ito Y, Asada A, Kobayashi H, Takano T, Sharma G, Saito T, Ohta Y, Amano M, Kaibuchi K, Hisanaga S.

Mol Cell Neurosci. 2014 Jul;61:34-45. doi: 10.1016/j.mcn.2014.05.006. Epub 2014 May 27.

PMID:
24877974
4.

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.

Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH.

J Neurosci. 2001 Sep 1;21(17):6758-71.

5.

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.

Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, Zheng JQ, Feng Y.

J Neurosci. 2016 Nov 2;36(44):11283-11294.

6.

Phosphorylation of p35 and p39 by Cdk5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner.

Asada A, Saito T, Hisanaga S.

J Cell Sci. 2012 Jul 15;125(Pt 14):3421-9. doi: 10.1242/jcs.100503. Epub 2012 Mar 30.

7.

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.

Ohshima T, Ogawa M, Veeranna, Hirasawa M, Longenecker G, Ishiguro K, Pant HC, Brady RO, Kulkarni AB, Mikoshiba K.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2764-9. Epub 2001 Feb 13.

8.

Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.

Huang D, Patrick G, Moffat J, Tsai LH, Andrews B.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14445-50.

10.

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity.

Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai LH.

Nature. 1998 Sep 10;395(6698):194-8.

PMID:
9744280
12.

p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair.

Bankston AN, Li W, Zhang H, Ku L, Liu G, Papa F, Zhao L, Bibb JA, Cambi F, Tiwari-Woodruff SK, Feng Y.

J Biol Chem. 2013 Jun 21;288(25):18047-57. doi: 10.1074/jbc.M113.453688. Epub 2013 May 3.

13.

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.

Hisanaga S, Saito T.

Neurosignals. 2003 Sep-Oct;12(4-5):221-9. Review.

PMID:
14673209
14.

Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.

Saito T, Yano M, Kawai Y, Asada A, Wada M, Doi H, Hisanaga S.

J Biol Chem. 2013 Nov 8;288(45):32433-9. doi: 10.1074/jbc.M113.512293. Epub 2013 Sep 30.

15.

Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.

Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, Asada A, Kamada S, Ohshima T, Hisanaga S.

J Biol Chem. 2014 Jul 11;289(28):19627-36. doi: 10.1074/jbc.M113.501148. Epub 2014 May 28.

16.

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

Li BS, Zhang L, Takahashi S, Ma W, Jaffe H, Kulkarni AB, Pant HC.

EMBO J. 2002 Feb 1;21(3):324-33.

17.

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH.

Genes Dev. 1996 Apr 1;10(7):816-25.

18.

Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.

Lilja L, Johansson JU, Gromada J, Mandic SA, Fried G, Berggren PO, Bark C.

J Biol Chem. 2004 Jul 9;279(28):29534-41. Epub 2004 Apr 26.

19.

The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity.

Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ.

J Biol Chem. 2002 Mar 1;277(9):7324-32. Epub 2001 Dec 10.

20.

Synaptic localization of p39, a neuronal activator of cdk5.

Humbert S, Lanier LM, Tsai LH.

Neuroreport. 2000 Jul 14;11(10):2213-6.

PMID:
10923673

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