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Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

Ramirez M, Wek RC, Vazquez de Aldana CR, Jackson BM, Freeman B, Hinnebusch AG.

Mol Cell Biol. 1992 Dec;12(12):5801-15.


Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.

Berlanga JJ, Santoyo J, De Haro C.

Eur J Biochem. 1999 Oct;265(2):754-62.


Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.

Yang R, Wek SA, Wek RC.

Mol Cell Biol. 2000 Apr;20(8):2706-17.


Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

Dever TE, Chen JJ, Barber GN, Cigan AM, Feng L, Donahue TF, London IM, Katze MG, Hinnebusch AG.

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4616-20.


Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.

Lageix S, Zhang J, Rothenburg S, Hinnebusch AG.

PLoS Genet. 2015 Feb 19;11(2):e1004991. doi: 10.1371/journal.pgen.1004991. eCollection 2015 Feb.


Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

Kubota H, Obata T, Ota K, Sasaki T, Ito T.

J Biol Chem. 2003 Jun 6;278(23):20457-60. Epub 2003 Apr 2.


Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region.

Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y.

J Biol Chem. 2008 Feb 1;283(5):2543-53. Epub 2007 Nov 30.

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