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The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins.

Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM.

Oncogene. 1998 Oct 15;17(15):1893-901.


p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.

Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD.

J Biol Chem. 1996 Oct 11;271(41):25198-203.


Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, Saksela K.

J Biol Chem. 2008 Feb 29;283(9):5719-27. doi: 10.1074/jbc.M707195200. Epub 2007 Dec 28.


Physiological signals and oncogenesis mediated through Crk family adapter proteins.

Feller SM, Posern G, Voss J, Kardinal C, Sakkab D, Zheng J, Knudsen BS.

J Cell Physiol. 1998 Dec;177(4):535-52. Review.


Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades.

Blaukat A, Ivankovic-Dikic I, Grönroos E, Dolfi F, Tokiwa G, Vuori K, Dikic I.

J Biol Chem. 1999 May 21;274(21):14893-901.


CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells.

Arai A, Aoki M, Weihua Y, Jin A, Miura O.

Cell Signal. 2006 Dec;18(12):2162-71. Epub 2006 May 16.


c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.

Xing L, Ge C, Zeltser R, Maskevitch G, Mayer BJ, Alexandropoulos K.

Mol Cell Biol. 2000 Oct;20(19):7363-77.


C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells.

de Jong R, van Wijk A, Heisterkamp N, Groffen J.

Oncogene. 1998 Nov 26;17(21):2805-10.


SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.

Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T.

J Biol Chem. 1997 Oct 31;272(44):27804-11.


Crk family adaptors-signalling complex formation and biological roles.

Feller SM.

Oncogene. 2001 Oct 1;20(44):6348-71. Review.


v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras.

Akagi T, Murata K, Shishido T, Hanafusa H.

Mol Cell Biol. 2002 Oct;22(20):7015-23.


GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway.

Shi CS, Tuscano JM, Witte ON, Kehrl JH.

Blood. 1999 Feb 15;93(4):1338-45.


CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses.

Hrincius ER, Wixler V, Wolff T, Wagner R, Ludwig S, Ehrhardt C.

Cell Microbiol. 2010 Jun;12(6):831-43. doi: 10.1111/j.1462-5822.2010.01436.x. Epub 2010 Jan 29.


The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways.

Voss J, Posern G, Hannemann JR, Wiedemann LM, Turhan AG, Poirel H, Bernard OA, Adermann K, Kardinal C, Feller SM.

Oncogene. 2000 Mar 23;19(13):1684-90.


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