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Items: 1 to 20 of 42


The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.

Morimoto AM, Tomlinson MG, Nakatani K, Bolen JB, Roth RA, Herbst R.

Oncogene. 2000 Jan 13;19(2):200-9.


Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.

Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK.

Mol Cancer Ther. 2005 Nov;4(11):1681-8.


Functional and therapeutic significance of Akt deregulation in malignant melanoma.

Robertson GP.

Cancer Metastasis Rev. 2005 Jun;24(2):273-85. Review.


Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression.

Graff JR, Konicek BW, McNulty AM, Wang Z, Houck K, Allen S, Paul JD, Hbaiu A, Goode RG, Sandusky GE, Vessella RL, Neubauer BL.

J Biol Chem. 2000 Aug 11;275(32):24500-5.


Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.

Xie D, Yin D, Tong X, O'Kelly J, Mori A, Miller C, Black K, Gui D, Said JW, Koeffler HP.

Cancer Res. 2004 Mar 15;64(6):1987-96.


MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranylgeranylated and farnesylated proteins in Fc epsilonRI-mediated signaling.

Graham TE, Pfeiffer JR, Lee RJ, Kusewitt DF, Martinez AM, Foutz T, Wilson BS, Oliver JM.

J Immunol. 1998 Dec 15;161(12):6733-44.


mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.

Yacoub A, Mitchell C, Lebedeva IV, Sarkar D, Su ZZ, McKinstry R, Gopalkrishnan RV, Grant S, Fisher PB, Dent P.

Cancer Biol Ther. 2003 Jul-Aug;2(4):347-53.


ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.

Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D.

Cancer Res. 2006 Aug 1;66(15):7473-81.


The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.

Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15587-91.


LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways.

Wu M, Chen Q, Li D, Li X, Li X, Huang C, Tang Y, Zhou Y, Wang D, Tang K, Cao L, Shen S, Li G.

J Cell Biochem. 2008 Jan 1;103(1):245-55.


Cell adhesion regulates platelet-derived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cells.

Carloni V, Defranco RM, Caligiuri A, Gentilini A, Sciammetta SC, Baldi E, Lottini B, Gentilini P, Pinzani M.

Hepatology. 2002 Sep;36(3):582-91.


MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells.

Tanaka M, Koul D, Davies MA, Liebert M, Steck PA, Grossman HB.

Oncogene. 2000 Nov 9;19(47):5406-12.


Osteopontin: it's role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression.

Das R, Philip S, Mahabeleshwar GH, Bulbule A, Kundu GC.

IUBMB Life. 2005 Jun;57(6):441-7. Review.


Integrin-linked kinase (ILK): a "hot" therapeutic target.

Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D, Zhang Z, Yee A, Dedhar S, Sanghera J.

Biochem Pharmacol. 2000 Oct 15;60(8):1115-9. Review.


Focal adhesion kinase promotes phospholipase C-gamma1 activity.

Zhang X, Chattopadhyay A, Ji QS, Owen JD, Ruest PJ, Carpenter G, Hanks SK.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9021-6.


Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole.

Faehling M, Kroll J, Föhr KJ, Fellbrich G, Mayr U, Trischler G, Waltenberger J.

FASEB J. 2002 Nov;16(13):1805-7. Epub 2002 Sep 19.


Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.

Clin Cancer Res. 2004 Dec 1;10(23):8059-67.


PLCgamma1 is essential for early events in integrin signalling required for cell motility.

Jones NP, Peak J, Brader S, Eccles SA, Katan M.

J Cell Sci. 2005 Jun 15;118(Pt 12):2695-706.


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