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Characterization of a chimeric T-cell receptor with specificity for the Hodgkin's lymphoma-associated CD30 antigen.

Hombach A, Heuser C, Sircar R, Tillmann T, Diehl V, Pohl C, Abken H.

J Immunother. 1999 Nov;22(6):473-80.


An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30.

Hombach A, Heuser C, Sircar R, Tillmann T, Diehl V, Pohl C, Abken H.

Cancer Res. 1998 Mar 15;58(6):1116-9.


Chimeric anti-TAG72 receptors with immunoglobulin constant Fc domains and gamma or zeta signalling chains.

Hombach A, Sircar R, Heuser C, Tillmann T, Diehl V, Kruis W, Pohl C, Abken H.

Int J Mol Med. 1998 Jul;2(1):99-103.


In vitro and in vivo antitumor activity of a mouse CTL hybridoma expressing chimeric receptors bearing the single chain Fv from HER-2/neu- specific antibody and the gamma-chain from Fc(epsilon) RI.

Mamalaki A, Gritzapis AD, Kretsovali A, Belimezi M, Papamatheakis J, Perez SA, Papamichail M, Baxevanis CN.

Cancer Immunol Immunother. 2003 Aug;52(8):513-22. Epub 2003 Apr 25.


T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope.

Hombach A, Heuser C, Sircar R, Tillmann T, Diehl V, Kruis W, Pohl C, Abken H.

Gastroenterology. 1997 Oct;113(4):1163-70.


Anti-CD30-scFv-Fc-IL-2 antibody-cytokine fusion protein that induces resting NK cells to highly efficient cytolysis of Hodgkin's lymphoma derived tumour cells.

Heuser C, Guhlke S, Matthies A, Bender H, Barth S, Diehl V, Abken H, Hombach A.

Int J Cancer. 2004 Jun 20;110(3):386-94.


Functional humanization of an anti-CD30 Fab fragment for the immunotherapy of Hodgkin's lymphoma using an in vitro evolution approach.

Schlapschy M, Gruber H, Gresch O, Schäfer C, Renner C, Pfreundschuh M, Skerra A.

Protein Eng Des Sel. 2004 Dec;17(12):847-60. Epub 2005 Feb 11.


An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETA') is a potent immunotoxin against a Hodgkin-derived cell line.

Klimka A, Barth S, Matthey B, Roovers RC, Lemke H, Hansen H, Arends JW, Diehl V, Hoogenboom HR, Engert A.

Br J Cancer. 1999 Jun;80(8):1214-22.


Generation of the single chain antibody fragment conserves the idiotypic profile of the anti-CD30 monoclonal antibody HRS3.

Hombach A, Pohl C, Heuser C, Sircar R, Koch D, Diehl V, Abken H.

Scand J Immunol. 1998 Nov;48(5):497-501. Erratum in: Scand J Immunol 1999 Aug;50(2):232.


Isolation of single chain antibody fragments with specificity for cell surface antigens by phage display utilizing internal image anti-idiotypic antibodies.

Hombach A, Pohl C, Heuser C, Sircar R, Diehl V, Abken H.

J Immunol Methods. 1998 Sep 1;218(1-2):53-61.


Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.

Moritz D, Wels W, Mattern J, Groner B.

Proc Natl Acad Sci U S A. 1994 May 10;91(10):4318-22.


Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.

Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E, Wakeham A, Mittruecker HW, Griesser H, Takimoto H, Schmits R, Shahinian A, Ohashi P, Penninger JM, Mak TW.

Cell. 1996 Feb 23;84(4):551-62.


The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease.

Wahl AF, Klussman K, Thompson JD, Chen JH, Francisco LV, Risdon G, Chace DF, Siegall CB, Francisco JA.

Cancer Res. 2002 Jul 1;62(13):3736-42.

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