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Items: 1 to 20 of 113


Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis.

Vantieghem A, Xu Y, Assefa Z, Piette J, Vandenheede JR, Merlevede W, De Witte PA, Agostinis P.

J Biol Chem. 2002 Oct 4;277(40):37718-31. Epub 2002 Jul 5.


Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells.

Tseng CJ, Wang YJ, Liang YC, Jeng JH, Lee WS, Lin JK, Chen CH, Liu IC, Ho YS.

Toxicology. 2002 Jun 14;175(1-3):123-42.


Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation.

Furukawa Y, Iwase S, Kikuchi J, Terui Y, Nakamura M, Yamada H, Kano Y, Matsuda M.

J Biol Chem. 2000 Jul 14;275(28):21661-7.


Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

Ling YH, Tornos C, Perez-Soler R.

J Biol Chem. 1998 Jul 24;273(30):18984-91.


Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis.

Srivastava RK, Mi QS, Hardwick JM, Longo DL.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3775-80.


Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells.

Wang TH, Popp DM, Wang HS, Saitoh M, Mural JG, Henley DC, Ichijo H, Wimalasena J.

J Biol Chem. 1999 Mar 19;274(12):8208-16.


Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation.

Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z.

J Neurosci. 2001 Jul 1;21(13):4657-67.


Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways.

Wang TH, Wang HS, Ichijo H, Giannakakou P, Foster JS, Fojo T, Wimalasena J.

J Biol Chem. 1998 Feb 27;273(9):4928-36.


Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest.

Scatena CD, Stewart ZA, Mays D, Tang LJ, Keefer CJ, Leach SD, Pietenpol JA.

J Biol Chem. 1998 Nov 13;273(46):30777-84.


Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.

Pathan N, Aime-Sempe C, Kitada S, Basu A, Haldar S, Reed JC.

Neoplasia. 2001 Nov-Dec;3(6):550-9.


Ebselen inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38 MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2.

Sarker KP, Biswas KK, Rosales JL, Yamaji K, Hashiguchi T, Lee KY, Maruyama I.

J Neurochem. 2003 Dec;87(6):1345-53.


SAPK/JNK regulates cdc2/cyclin B kinase through phosphorylation and inhibition of cdc25c.

Goss VL, Cross JV, Ma K, Qian Y, Mola PW, Templeton DJ.

Cell Signal. 2003 Jul;15(7):709-18.


Regulation of apoptosis by alpha-subunits of G12 and G13 proteins via apoptosis signal-regulating kinase-1.

Berestetskaya YV, Faure MP, Ichijo H, Voyno-Yasenetskaya TA.

J Biol Chem. 1998 Oct 23;273(43):27816-23.


Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade.

Fan M, Goodwin M, Vu T, Brantley-Finley C, Gaarde WA, Chambers TC.

J Biol Chem. 2000 Sep 29;275(39):29980-5.

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