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Items: 1 to 20 of 133

1.
3.

Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).

Hartmann RW, Hector M, Wachall BG, Palusczak A, Palzer M, Huch V, Veith M.

J Med Chem. 2000 Nov 16;43(23):4437-45.

PMID:
11087568
4.

Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 17, and P450 TxA2.

Hartmann RW, Frotscher M, Ledergerber D, Wächter GA, Grün GL, Sergejew TF.

Arch Pharm (Weinheim). 1996 May;329(5):251-61.

PMID:
8779634
5.

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.

J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):117-27. doi: 10.1016/j.jsbmb.2008.05.007. Epub 2008 Jun 21.

PMID:
18620055
6.

Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.

Hartmann RW, Hector M, Haidar S, Ehmer PB, Reichert W, Jose J.

J Med Chem. 2000 Nov 2;43(22):4266-77.

PMID:
11063622
7.

Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.

Wächter GA, Hartmann RW, Sergejew T, Grün GL, Ledergerber D.

J Med Chem. 1996 Feb 16;39(4):834-41.

PMID:
8632407
8.

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.

Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. doi: 10.1016/j.bmc.2008.07.011. Epub 2008 Jul 9.

PMID:
18674917
9.
10.

Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.

Haidar S, Ehmer PB, Barassin S, Batzl-Hartmann C, Hartmann RW.

J Steroid Biochem Mol Biol. 2003 Apr;84(5):555-62.

PMID:
12767280
11.
12.
13.

Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.

Hille UE, Hu Q, Vock C, Negri M, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.

Eur J Med Chem. 2009 Jul;44(7):2765-75. doi: 10.1016/j.ejmech.2009.01.002. Epub 2009 Jan 19.

PMID:
19211174
15.

CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: synthesis, biological evaluation and molecular modelling.

Pinto-Bazurco Mendieta MA, Negri M, Hu Q, Hille UE, Jagusch C, Jahn-Hoffmann K, Müller-Vieira U, Schmidt D, Lauterbach T, Hartmann RW.

Arch Pharm (Weinheim). 2008 Oct;341(10):597-609. doi: 10.1002/ardp.200700251.

PMID:
18720339
16.
17.

Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.

Pinto-Bazurco Mendieta MA, Negri M, Jagusch C, Müller-Vieira U, Lauterbach T, Hartmann RW.

J Med Chem. 2008 Aug 28;51(16):5009-18. doi: 10.1021/jm800355c. Epub 2008 Aug 2.

PMID:
18672868
18.

Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha).

Shahid I, Patel CH, Dhanani S, Owen CP, Ahmed S.

J Steroid Biochem Mol Biol. 2008 May;110(1-2):18-29. doi: 10.1016/j.jsbmb.2007.10.009. Epub 2008 Feb 12.

PMID:
18407491
19.

Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17 alpha-hydroxylase: 17, 20-lyase (P450 17) and their specificity patterns.

Bahshwan SA, Owen CP, Nicholls PJ, Smith HJ, Ahmadi M.

J Pharm Pharmacol. 1998 Oct;50(10):1109-16.

PMID:
9821656
20.

P450-dependent enzymes as targets for prostate cancer therapy.

De Coster R, Wouters W, Bruynseels J.

J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):133-43. Review.

PMID:
8603034

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