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Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

Shirane M, Hatakeyama S, Hattori K, Nakayama K, Nakayama K.

J Biol Chem. 1999 Oct 1;274(40):28169-74.


Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

Hatakeyama S, Kitagawa M, Nakayama K, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoé K, Good RA, Nakayama K.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63.


Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha.

Hattori K, Hatakeyama S, Shirane M, Matsumoto M, Nakayama K.

J Biol Chem. 1999 Oct 15;274(42):29641-7.


beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.

Wu C, Ghosh S.

J Biol Chem. 1999 Oct 15;274(42):29591-4.


The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1.

Hayakawa M, Kitagawa H, Miyazawa K, Kitagawa M, Kikugawa K.

Genes Cells. 2005 Mar;10(3):241-51.


An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.

Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori K, Nakamichi I, Kikuchi A, Nakayama K, Nakayama K.

EMBO J. 1999 May 4;18(9):2401-10.


Characterization of the nuclear import and export functions of Ikappa B(epsilon).

Lee SH, Hannink M.

J Biol Chem. 2002 Jun 28;277(26):23358-66. Epub 2002 Apr 22.


The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.

Genes Dev. 1999 Feb 1;13(3):270-83. Erratum in: Genes Dev 1999 Apr 15;13(8):1050.


Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.

Spencer E, Jiang J, Chen ZJ.

Genes Dev. 1999 Feb 1;13(3):284-94.


IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

Suzuki H, Chiba T, Kobayashi M, Takeuchi M, Suzuki T, Ichiyama A, Ikenoue T, Omata M, Furuichi K, Tanaka K.

Biochem Biophys Res Commun. 1999 Mar 5;256(1):127-32.


Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation.

Doerre S, Mesires KP, Daley KM, McCarty T, Knoetig S, Corley RB.

J Immunol. 2005 Jan 15;174(2):983-91.


Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.

Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ.

Mol Cell Biol. 2000 Apr;20(7):2326-33.


Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.

Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y.

Nature. 1998 Dec 10;396(6711):590-4.


Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.

Spiegelman VS, Stavropoulos P, Latres E, Pagano M, Ronai Z, Slaga TJ, Fuchs SY.

J Biol Chem. 2001 Jul 20;276(29):27152-8. Epub 2001 May 24.


Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.

Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K.

J Biol Chem. 2000 Jan 28;275(4):2877-84.


Structure-function relationship of cytoplasmic and nuclear IκB proteins: an in silico analysis.

Manavalan B, Basith S, Choi YM, Lee G, Choi S.

PLoS One. 2010 Dec 23;5(12):e15782. doi: 10.1371/journal.pone.0015782.


IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis.

Mémet S, Laouini D, Epinat JC, Whiteside ST, Goudeau B, Philpott D, Kayal S, Sansonetti PJ, Berche P, Kanellopoulos J, Israël A.

J Immunol. 1999 Dec 1;163(11):5994-6005.

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