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Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization.

Xu Y, Ambudkar I, Yamagishi H, Swaim W, Walsh TJ, O'Connell BC.

Antimicrob Agents Chemother. 1999 Sep;43(9):2256-62.


Candidacidal activity of salivary histatins. Identification of a histatin 5-binding protein on Candida albicans.

Edgerton M, Koshlukova SE, Lo TE, Chrzan BG, Straubinger RM, Raj PA.

J Biol Chem. 1998 Aug 7;273(32):20438-47.


Killing of Candida albicans by histatin 5: cellular uptake and energy requirement.

Gyurko C, Lendenmann U, Helmerhorst EJ, Troxler RF, Oppenheim FG.

Antonie Van Leeuwenhoek. 2001 Sep;79(3-4):297-309.


Binding, internalisation and degradation of histatin 3 in histatin-resistant derivatives of Candida albicans.

Fitzgerald DH, Coleman DC, O'Connell BC.

FEMS Microbiol Lett. 2003 Mar 28;220(2):247-53.


Saliva affects the antifungal activity of exogenously added histatin 3 towards Candida albicans.

Yamagishi H, Fitzgerald DH, Sein T, Walsh TJ, O'Connell BC.

FEMS Microbiol Lett. 2005 Mar 1;244(1):207-12.


Anticandidal activity of major human salivary histatins.

Xu T, Levitz SM, Diamond RD, Oppenheim FG.

Infect Immun. 1991 Aug;59(8):2549-54.


Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.

Yin A, Margolis HC, Grogan J, Yao Y, Troxler RF, Oppenheim FG.

Arch Oral Biol. 2003 May;48(5):361-8.


Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption.

Vylkova S, Nayyar N, Li W, Edgerton M.

Antimicrob Agents Chemother. 2007 Jan;51(1):154-61. Epub 2006 Oct 30.


Candida albicans mutants deficient in respiration are resistant to the small cationic salivary antimicrobial peptide histatin 5.

Gyurko C, Lendenmann U, Troxler RF, Oppenheim FG.

Antimicrob Agents Chemother. 2000 Feb;44(2):348-54.


Differentially expressed proteins in derivatives of Candida albicans displaying a stable histatin 3-resistant phenotype.

Fitzgerald-Hughes DH, Coleman DC, O'Connell BC.

Antimicrob Agents Chemother. 2007 Aug;51(8):2793-800. Epub 2007 May 7.


Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans.

Baev D, Li XS, Dong J, Keng P, Edgerton M.

Infect Immun. 2002 Sep;70(9):4777-84.


Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death.

Koshlukova SE, Lloyd TL, Araujo MW, Edgerton M.

J Biol Chem. 1999 Jul 2;274(27):18872-9.


The cellular target of histatin 5 on Candida albicans is the energized mitochondrion.

Helmerhorst EJ, Breeuwer P, van't Hof W, Walgreen-Weterings E, Oomen LC, Veerman EC, Amerongen AV, Abee T.

J Biol Chem. 1999 Mar 12;274(11):7286-91.


Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans.

Jang WS, Bajwa JS, Sun JN, Edgerton M.

Mol Microbiol. 2010 Jul;77(2):354-70. doi: 10.1111/j.1365-2958.2010.07210.x. Epub 2010 May 12.


The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species.

Helmerhorst EJ, Troxler RF, Oppenheim FG.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42. Epub 2001 Nov 20.

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