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Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.

Shtrichman R, Sharf R, Barr H, Dobner T, Kleinberger T.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10080-5.


Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.

Marcellus RC, Chan H, Paquette D, Thirlwell S, Boivin D, Branton PE.

J Virol. 2000 Sep;74(17):7869-77.


Selection of apoptosis-deficient adenovirus E4orf4 mutants in Saccharomyces cerevisiae.

Afifi R, Sharf R, Shtrichman R, Kleinberger T.

J Virol. 2001 May;75(9):4444-7. Erratum in: J Virol 2001 Jun;75(12):5719.


Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A.

Roopchand DE, Lee JM, Shahinian S, Paquette D, Bussey H, Branton PE.

Oncogene. 2001 Aug 30;20(38):5279-90.


Activation of adenovirus type 2 early region 4 ORF4 cytoplasmic death function by direct binding to Src kinase domain.

Champagne C, Landry MC, Gingras MC, Lavoie JN.

J Biol Chem. 2004 Jun 11;279(24):25905-15. Epub 2004 Apr 7.


Induction of apoptosis by adenovirus E4orf4 protein.

Kleinberger T.

Apoptosis. 2000 Jun;5(3):211-5. Review.


Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.

Ben-Israel H, Sharf R, Rechavi G, Kleinberger T.

J Virol. 2008 Oct;82(19):9381-8. doi: 10.1128/JVI.00791-08. Epub 2008 Jul 23.


The role of adenovirus E4orf4 protein in viral replication and cell killing.

Branton PE, Roopchand DE.

Oncogene. 2001 Nov 26;20(54):7855-65. Review.


YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.

Maoz T, Koren R, Ben-Ari I, Kleinberger T.

J Biol Chem. 2005 Dec 16;280(50):41270-7. Epub 2005 Oct 14.


Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit.

Horowitz B, Sharf R, Avital-Shacham M, Pechkovsky A, Kleinberger T.

J Biol Chem. 2013 May 10;288(19):13718-27. doi: 10.1074/jbc.M112.343756. Epub 2013 Mar 25.


The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.

Li S, Brignole C, Marcellus R, Thirlwell S, Binda O, McQuoid MJ, Ashby D, Chan H, Zhang Z, Miron MJ, Pallas DC, Branton PE.

J Virol. 2009 Sep;83(17):8340-52. doi: 10.1128/JVI.00711-09. Epub 2009 Jun 17.


Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.

Lavoie JN, Champagne C, Gingras MC, Robert A.

J Cell Biol. 2000 Sep 4;150(5):1037-56.


Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.

Zhang Z, Mui MZ, Chan F, Roopchand DE, Marcellus RC, Blanchette P, Li S, Berghuis AM, Branton PE.

J Virol. 2011 Jan;85(1):286-95. doi: 10.1128/JVI.01381-10. Epub 2010 Nov 3.


Induction of transformed cell-specific apoptosis by the adenovirus E4orf4 protein.

Kleinberger T.

Prog Mol Subcell Biol. 2004;36:245-67. Review. No abstract available.


Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death.

Miron MJ, Gallouzi IE, Lavoie JN, Branton PE.

Oncogene. 2004 Sep 30;23(45):7458-68. Erratum in: Oncogene. 2005 Jun 9;24(25):4162.


Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.

Li Y, Wei H, Hsieh TC, Pallas DC.

J Virol. 2008 Apr;82(7):3612-23. doi: 10.1128/JVI.02435-07. Epub 2008 Jan 23.

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