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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

Xu XN, Laffert B, Screaton GR, Kraft M, Wolf D, Kolanus W, Mongkolsapay J, McMichael AJ, Baur AS.

J Exp Med. 1999 May 3;189(9):1489-96.


The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs.

Schaefer TM, Bell I, Pfeifer ME, Ghosh M, Trible RP, Fuller CL, Ashman C, Reinhart TA.

Virology. 2002 Oct 10;302(1):106-22.


Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.

Zauli G, Gibellini D, Secchiero P, Dutartre H, Olive D, Capitani S, Collette Y.

Blood. 1999 Feb 1;93(3):1000-10.


HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.

Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC.

Nature. 2001 Apr 12;410(6830):834-8.


Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway.

Manninen A, Renkema GH, Saksela K.

J Biol Chem. 2000 Jun 2;275(22):16513-7.


Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.

Krautkrämer E, Giese SI, Gasteier JE, Muranyi W, Fackler OT.

J Virol. 2004 Apr;78(8):4085-97.


CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

Lu X, Wu X, Plemenitas A, Yu H, Sawai ET, Abo A, Peterlin BM.

Curr Biol. 1996 Dec 1;6(12):1677-84.


Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques.

Sawai ET, Khan IH, Montbriand PM, Peterlin BM, Cheng-Mayer C, Luciw PA.

Curr Biol. 1996 Nov 1;6(11):1519-27.


Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation.

Bell I, Ashman C, Maughan J, Hooker E, Cook F, Reinhart TA.

J Gen Virol. 1998 Nov;79 ( Pt 11):2717-27.


Two sorting motifs, a ubiquitination motif and a tyrosine motif, are involved in HIV-1 and simian immunodeficiency virus Nef-mediated receptor endocytosis.

Cai CY, Zhang X, Sinko PJ, Burakoff SJ, Jin YJ.

J Immunol. 2011 May 15;186(10):5807-14. doi: 10.4049/jimmunol.1003506. Epub 2011 Apr 11.


The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.

Haller C, Rauch S, Michel N, Hannemann S, Lehmann MJ, Keppler OT, Fackler OT.

J Biol Chem. 2006 Jul 14;281(28):19618-30. Epub 2006 May 10.


Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.

Hodge S, Novembre FJ, Whetter L, Gelbard HA, Dewhurst S.

Virology. 1998 Dec 20;252(2):354-63.


The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase.

Baur AS, Sass G, Laffert B, Willbold D, Cheng-Mayer C, Peterlin BM.

Immunity. 1997 Mar;6(3):283-91.


Grb3-3 is up-regulated in HIV-1-infected T-cells and can potentiate cell activation through NFATc.

Li X, Multon MC, Henin Y, Schweighoffer F, Venot C, Josef J, Zhou C, LaVecchio J, Stuckert P, Raab M, Mhashilkar A, Tocque B, Marasco WA.

J Biol Chem. 2000 Oct 6;275(40):30925-33.

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