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Items: 1 to 20 of 245

1.

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.

Schwartz HL, Chandonia JM, Kash SF, Kanaani J, Tunnell E, Domingo A, Cohen FE, Banga JP, Madec AM, Richter W, Baekkeskov S.

J Mol Biol. 1999 Apr 16;287(5):983-99.

PMID:
10222205
2.

Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling.

Myers MA, Davies JM, Tong JC, Whisstock J, Scealy M, Mackay IR, Rowley MJ.

J Immunol. 2000 Oct 1;165(7):3830-8.

3.
4.

Structural determinants of GAD antigenicity.

Arafat Y, Fenalti G, Whisstock JC, Mackay IR, Garcia de la Banda M, Rowley MJ, Buckle AM.

Mol Immunol. 2009 Dec;47(2-3):493-505. doi: 10.1016/j.molimm.2009.08.022. Epub 2009 Sep 23.

PMID:
19783309
5.

Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies.

Tree TI, Morgenthaler NG, Duhindan N, Hicks KE, Madec AM, Scherbaum WA, Banga JP.

Diabetologia. 2000 Jul;43(7):881-9.

PMID:
10952461
6.

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ.

Diabetes. 2008 May;57(5):1293-301. doi: 10.2337/db07-1461. Epub 2008 Jan 9.

7.

The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.

Tong JC, Myers MA, Mackay IR, Zimmet PZ, Rowley MJ.

Ann N Y Acad Sci. 2002 Apr;958:182-9.

PMID:
12021103
8.

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O.

Mol Immunol. 2007 Feb;44(6):1178-89. Epub 2006 Aug 22.

PMID:
16930708
9.

Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase.

Syren K, Lindsay L, Stoehrer B, Jury K, Lühder F, Baekkeskov S, Richter W.

J Immunol. 1996 Dec 1;157(11):5208-14.

PMID:
8943434
10.

Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis.

Al-Bukhari TA, Radford PM, Bouras G, Davenport C, Trigwell SM, Bottazzo GF, Lai M, Schwartz HL, Tighe PJ, Todd I.

Clin Exp Immunol. 2002 Oct;130(1):131-9.

11.

GAD65 as a prototypic autoantigen.

Fenalti G, Rowley MJ.

J Autoimmun. 2008 Nov;31(3):228-32. doi: 10.1016/j.jaut.2008.04.013. Epub 2008 Jun 2.

PMID:
18514483
12.

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.

Solimena M, Dirkx R Jr, Radzynski M, Mundigl O, De Camilli P.

J Cell Biol. 1994 Jul;126(2):331-41.

13.

Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.

Plesner A, Hampe CS, Daniels TL, Hammerle LP, Lernmark A.

Autoimmunity. 2001;34(4):221-30.

PMID:
11905848
14.

Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

Kim J, Richter W, Aanstoot HJ, Shi Y, Fu Q, Rajotte R, Warnock G, Baekkeskov S.

Diabetes. 1993 Dec;42(12):1799-808.

PMID:
8243826
15.

Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients.

Raju R, Foote J, Banga JP, Hall TR, Padoa CJ, Dalakas MC, Ortqvist E, Hampe CS.

J Immunol. 2005 Dec 1;175(11):7755-62.

18.

A diabetes-related epitope of GAD65: a major diabetes-related conformational epitope on GAD65.

Myers MA, Fenalti G, Gray R, Scealy M, Tong JC, El-Kabbani O, Rowley MJ.

Ann N Y Acad Sci. 2003 Nov;1005:250-2.

PMID:
14679070
19.

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.

Patel SD, Cope AP, Congia M, Chen TT, Kim E, Fugger L, Wherrett D, Sonderstrup-McDevitt G.

Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8082-7.

20.

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.

Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC.

Nat Struct Mol Biol. 2007 Apr;14(4):280-6. Epub 2007 Mar 25.

PMID:
17384644

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