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Items: 1 to 20 of 91

1.

Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein.

Giovannini M, Robanus-Maandag E, Niwa-Kawakita M, van der Valk M, Woodruff JM, Goutebroze L, Mérel P, Berns A, Thomas G.

Genes Dev. 1999 Apr 15;13(8):978-86.

2.

Interdomain binding mediates tumor growth suppression by the NF2 gene product.

Sherman L, Xu HM, Geist RT, Saporito-Irwin S, Howells N, Ponta H, Herrlich P, Gutmann DH.

Oncogene. 1997 Nov 13;15(20):2505-9.

3.
4.

Tumor suppressor schwannomin/merlin is critical for the organization of Schwann cell contacts in peripheral nerves.

Denisenko N, Cifuentes-Diaz C, Irinopoulou T, Carnaud M, Benoit E, Niwa-Kawakita M, Chareyre F, Giovannini M, Girault JA, Goutebroze L.

J Neurosci. 2008 Oct 15;28(42):10472-81. doi: 10.1523/JNEUROSCI.2537-08.2008.

5.

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff JM, Berns A, Thomas G.

Genes Dev. 2000 Jul 1;14(13):1617-30.

6.

Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2.

Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO.

Neoplasia. 2002 Nov-Dec;4(6):501-9.

7.

Mouse models of neurofibromatosis 1 and 2.

Gutmann DH, Giovannini M.

Neoplasia. 2002 Jul-Aug;4(4):279-90.

8.

The importance of nerve microenvironment for schwannoma development.

Schulz A, Büttner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner VF, Mindos T, Parkinson DB, Gehlhausen JR, Clapp DW, Morrison H.

Acta Neuropathol. 2016 Aug;132(2):289-307. doi: 10.1007/s00401-016-1583-8. Epub 2016 May 28.

9.

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.

Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KM, Kirschner LS.

Oncogene. 2013 Jul 25;32(30):3491-9. doi: 10.1038/onc.2012.374. Epub 2012 Oct 8.

10.

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells.

Pelton PD, Sherman LS, Rizvi TA, Marchionni MA, Wood P, Friedman RA, Ratner N.

Oncogene. 1998 Oct 29;17(17):2195-209.

11.

Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients.

Rosenbaum C, Kluwe L, Mautner VF, Friedrich RE, Müller HW, Hanemann CO.

Neurobiol Dis. 1998 Jul;5(1):55-64.

PMID:
9702788
12.

Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain.

Koga H, Araki N, Takeshima H, Nishi T, Hirota T, Kimura Y, Nakao M, Saya H.

Oncogene. 1998 Aug 20;17(7):801-10.

13.

The neurofibromatosis type 2 gene is inactivated in schwannomas.

Twist EC, Ruttledge MH, Rousseau M, Sanson M, Papi L, Merel P, Delattre O, Thomas G, Rouleau GA.

Hum Mol Genet. 1994 Jan;3(1):147-51.

PMID:
8162016
14.

Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway.

Gautreau A, Manent J, Fievet B, Louvard D, Giovannini M, Arpin M.

J Biol Chem. 2002 Aug 30;277(35):31279-82. Epub 2002 Jul 18.

15.

Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.

Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp SK, Chen CS, Giovannini M, Jacob A, Welling DB, Chang LS.

Eur J Cancer. 2009 Jun;45(9):1709-20. doi: 10.1016/j.ejca.2009.03.013. Epub 2009 Apr 7.

16.

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.

McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T.

Genes Dev. 1998 Apr 15;12(8):1121-33.

17.

Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas.

Sainz J, Huynh DP, Figueroa K, Ragge NK, Baser ME, Pulst SM.

Hum Mol Genet. 1994 Jun;3(6):885-91.

PMID:
7951231
18.

Expression of schwannomin in lens and Schwann cells.

Claudio JO, Veneziale RW, Menko AS, Rouleau GA.

Neuroreport. 1997 May 27;8(8):2025-30.

PMID:
9223096
20.

Loss of the NF2 gene and merlin occur by the tumorlet stage of schwannoma development in neurofibromatosis 2.

Stemmer-Rachamimov AO, Ino Y, Lim ZY, Jacoby LB, MacCollin M, Gusella JF, Ramesh V, Louis DN.

J Neuropathol Exp Neurol. 1998 Dec;57(12):1164-7.

PMID:
9862639

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