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β‑estradiol alleviates hypertension‑ and concanavalin A‑mediated inflammatory responses via modulation of connexins in peripheral blood lymphocytes.

Ni X, Zhang L, Ma X, Shan LY, Li L, Si JQ, Li XZ, Zhang YY, Ma KT.

Mol Med Rep. 2019 May;19(5):3743-3755. doi: 10.3892/mmr.2019.10037. Epub 2019 Mar 14.


Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats.

Ni X, Li XZ, Fan ZR, Wang A, Zhang HC, Zhang L, Li L, Si JQ, Ma KT.

Cell Mol Biol Lett. 2018 Aug 20;23:40. doi: 10.1186/s11658-018-0106-0. eCollection 2018.


Hydrogen Sulfide Attenuates Hypertensive Inflammation via Regulating Connexin Expression in Spontaneously Hypertensive Rats.

Ni X, Zhang L, Peng M, Shen TW, Yu XS, Shan LY, Li L, Si JQ, Li XZ, Ma KT.

Med Sci Monit. 2018 Feb 27;24:1205-1218.


Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension.

Ni X, Wang A, Zhang L, Shan LY, Zhang HC, Li L, Si JQ, Luo J, Li XZ, Ma KT.

PLoS One. 2017 Sep 14;12(9):e0184773. doi: 10.1371/journal.pone.0184773. eCollection 2017.


Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation.

Zhang HC, Zhang ZS, Zhang L, Wang A, Zhu H, Li L, Si JQ, Li XZ, Ma KT.

Int J Mol Med. 2018 Jan;41(1):13-24. doi: 10.3892/ijmm.2017.3201. Epub 2017 Oct 20.


[An increase in the ratio of peripheral blood CD4+/CD8+ T lymphocytes and the levels of connexin 40 and inflammatory factors in spontaneously hypertensive rats].

Wang A, Zhang H, Zhang L, Li X, Li L, Si J, Ma K.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Feb;32(2):145-8. Chinese.


Enhanced expression of Cx43 and gap junction communication in vascular smooth muscle cells of spontaneously hypertensive rats.

Wang LJ, Liu WD, Zhang L, Ma KT, Zhao L, Shi WY, Zhang WW, Wang YZ, Li L, Si JQ.

Mol Med Rep. 2016 Nov;14(5):4083-4090. doi: 10.3892/mmr.2016.5783. Epub 2016 Sep 26.


Enhanced gap junctional channel activity between vascular smooth muscle cells in cerebral artery of spontaneously hypertensive rats.

Wang LJ, Ma KT, Shi WY, Wang YZ, Zhao L, Chen XY, Li XZ, Jiang XW, Zhang ZS, Li L, Si JQ.

Clin Exp Hypertens. 2017;39(4):295-305. doi: 10.1080/10641963.2016.1235181. Epub 2017 May 17.


Vascular gap junctions and implications for hypertension.

Rummery NM, Hill CE.

Clin Exp Pharmacol Physiol. 2004 Oct;31(10):659-67. Review.


Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension.

Harwani SC, Chapleau MW, Legge KL, Ballas ZK, Abboud FM.

Circ Res. 2012 Oct 12;111(9):1190-7. doi: 10.1161/CIRCRESAHA.112.277475. Epub 2012 Aug 17.


Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats.

Kansui Y, Fujii K, Nakamura K, Goto K, Oniki H, Abe I, Shibata Y, Iida M.

Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H216-24. Epub 2004 Mar 11.


[Roles of gap junctions in proliferation mediated by Hcy in the spontaneous hypertensive rat vascular smooth muscle cells].

Zhong H, Hu QH, Wang EB, Si JQ, Sun ZP, Li ZC, He F.

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Jul;28(4):289-93. Chinese.


Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats.

Zhao LL, Chen HJ, Chen JZ, Yu M, Ni YL, Zhang WF.

J Zhejiang Univ Sci B. 2008 Jun;9(6):448-54. doi: 10.1631/jzus.B0820050.


Decreased endothelial size and connexin expression in rat caudal arteries during hypertension.

Rummery NM, McKenzie KU, Whitworth JA, Hill CE.

J Hypertens. 2002 Feb;20(2):247-53.


[Slowing the progression of chronic renal insufficiency with captopril in rats with spontaneous arterial hypertension and adriamycin nephropathy].

Jovanović DB, Jovović Dj, Varagić J, Dimitrijević J, Dragojlović Z, Djukanović L.

Srp Arh Celok Lek. 2002 Mar-Apr;130(3-4):73-80. Serbian.


Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats.

Agarwal D, Haque M, Sriramula S, Mariappan N, Pariaut R, Francis J.

Hypertension. 2009 Dec;54(6):1393-400. doi: 10.1161/HYPERTENSIONAHA.109.135459. Epub 2009 Oct 19.


Regulation of gap junctions in melanoma and their impact on Melan-A/MART-1-specific CD8⁺ T lymphocyte emergence.

Benlalam H, Carré T, Jalil A, Noman Z, Caillou B, Vielh P, Tittarelli A, Robert C, Chouaib S.

J Mol Med (Berl). 2013 Oct;91(10):1207-20. doi: 10.1007/s00109-013-1058-5. Epub 2013 Jun 7.


Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.

Toth P, Csiszar A, Sosnowska D, Tucsek Z, Cseplo P, Springo Z, Tarantini S, Sonntag WE, Ungvari Z, Koller A.

Br J Pharmacol. 2013 Apr;168(8):1878-88. doi: 10.1111/bph.12079.


Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration.

Cao L, Zou Y, Zhu J, Fan X, Li J.

Mol Cell Biochem. 2013 Aug;380(1-2):203-10. doi: 10.1007/s11010-013-1674-y. Epub 2013 May 11.


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