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Items: 1 to 20 of 99

1.

Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930.

Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Matsui Y, Wakimoto S, Ogata T, Araki K, Sawamura R, Watanabe N, Mori M, Tanaka J.

ACS Med Chem Lett. 2019 Feb 26;10(3):358-362. doi: 10.1021/acsmedchemlett.8b00645. eCollection 2019 Mar 14.

PMID:
30891140
2.

Structure activity relationships of substituted benzimidazoles.

Brändström A, Lindberg P, Junggren U.

Scand J Gastroenterol Suppl. 1985;108:15-22.

PMID:
3858974
3.

Bioisosteres of arecoline: 1,2,3,6-tetrahydro-5-pyridyl-substituted and 3-piperidyl-substituted derivatives of tetrazoles and 1,2,3-triazoles. Synthesis and muscarinic activity.

Moltzen EK, Pedersen H, Bøgesø KP, Meier E, Frederiksen K, Sánchez C, Løve Lembøl H.

J Med Chem. 1994 Nov 25;37(24):4085-99.

PMID:
7990109
4.

Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode.

Goebel M, Wolber G, Markt P, Staels B, Unger T, Kintscher U, Gust R.

Bioorg Med Chem. 2010 Aug 15;18(16):5885-95. doi: 10.1016/j.bmc.2010.06.102. Epub 2010 Jul 3.

PMID:
20656494
5.
6.

Relationships between the anthelmintic activity of eight derivatives of benzimidazole carbamates against Trichinella spiralis and their chemical structures.

Latif LA, Surin J.

Jpn J Med Sci Biol. 1993 Oct-Dec;46(5-6):203-14. Erratum in: Jpn J Med Sci Biol 1994 Apr;47(2):126.

PMID:
8051807
7.

Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.

Goebel M, Staels B, Unger T, Kintscher U, Gust R.

ChemMedChem. 2009 Jul;4(7):1136-42. doi: 10.1002/cmdc.200900067.

PMID:
19504532
8.

Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.

Bolli MH, Lescop C, Birker M, de Kanter R, Hess P, Kohl C, Nayler O, Rey M, Sieber P, Velker J, Weller T, Steiner B.

Eur J Med Chem. 2016 Jun 10;115:326-41. doi: 10.1016/j.ejmech.2016.03.020. Epub 2016 Mar 12.

PMID:
27027817
9.

Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist.

Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH, Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM, Xu RX, Virley DJ.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in: Bioorg Med Chem Lett. 2013 Feb 15;23(4):1143. Wilson, Timothy M [corrected to Willson, Timothy M].

PMID:
21798739
10.

Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino-benzimidazoles.

Starcević K, Kralj M, Ester K, Sabol I, Grce M, Pavelić K, Karminski-Zamola G.

Bioorg Med Chem. 2007 Jul 1;15(13):4419-26. Epub 2007 Apr 25.

PMID:
17482821
11.

Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.

van Muijlwijk-Koezen JE, Timmerman H, Vollinga RC, Frijtag von Drabbe Künzel J, de Groote M, Visser S, IJzerman AP.

J Med Chem. 2001 Mar 1;44(5):749-62.

PMID:
11262085
12.

Structural Modifications of Benzimidazoles via Multi-Step Synthesis and Their Impact on Sirtuin-Inhibitory Activity.

Yoon YK, Choon TS.

Arch Pharm (Weinheim). 2016 Jan;349(1):1-8. doi: 10.1002/ardp.201500337. Epub 2015 Nov 30.

PMID:
26616218
13.

Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

Ishikawa M, Nonoshita K, Ogino Y, Nagae Y, Tsukahara D, Hosaka H, Maruki H, Ohyama S, Yoshimoto R, Sasaki K, Nagata Y, Eiki J, Nishimura T.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4450-4. doi: 10.1016/j.bmcl.2009.05.038. Epub 2009 May 18.

PMID:
19540111
14.

Research on differences between 2-(2'-pyridyl)benzimidazole and 2-(4'-pyridyl)benzimidazole based on terahertz time-domain spectroscopy.

Song M, Yang F, Liu L, Su C.

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Feb 15;191:125-133. doi: 10.1016/j.saa.2017.10.001. Epub 2017 Oct 2.

PMID:
29028504
15.

Relaxant activity of 2-(substituted phenyl)-1H-benzimidazoles on isolated rat aortic rings: design and synthesis of 5-nitro derivatives.

Estrada-Soto S, Villalobos-Molina R, Aguirre-Crespo F, Vergara-Galicia J, Moreno-Díaz H, Torres-Piedra M, Navarrete-Vázquez G.

Life Sci. 2006 Jun 27;79(5):430-5. Epub 2006 Feb 17.

PMID:
16487544
16.

Benzimidazole derivatives as potent inhibitors of milk xanthine oxidase.

Rudnicka R, Bojarska E, Kazimierczuk Z.

Acta Pol Pharm. 2004 Dec;61 Suppl:37-9.

PMID:
15909934
17.

Synthesis by radical cyclization and cytotoxicity of highly potent bioreductive alicyclic ring fused [1,2-a]benzimidazolequinones.

Lynch M, Hehir S, Kavanagh P, Leech D, O'Shaughnessy J, Carty MP, Aldabbagh F.

Chemistry. 2007;13(11):3218-26.

PMID:
17200920
18.

N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.

Jump SM, Kung J, Staub R, Kinseth MA, Cram EJ, Yudina LN, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Biochem Pharmacol. 2008 Feb 1;75(3):713-24. Epub 2007 Oct 2.

19.

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles.

Burgeson JR, Moore AL, Gharaibeh DN, Larson RA, Cerruti NR, Amberg SM, Hruby DE, Dai D.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. doi: 10.1016/j.bmcl.2012.11.093. Epub 2012 Dec 1.

PMID:
23265900
20.

Synthesis of Novel Substituted Thiourea and Benzimidazole Derivatives Containing a Pyrazolone Ring as Anti-Inflammatory Agents.

Moneer AA, Mohammed KO, El-Nassan HB.

Chem Biol Drug Des. 2016 May;87(5):784-93. doi: 10.1111/cbdd.12712. Epub 2016 Jan 17.

PMID:
26684979

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