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Items: 1 to 20 of 98

1.

Targeting RyR2 with a phosphorylation site-specific nanobody reverses dysfunction of failing cardiomyocytes in rats.

Li T, Shen Y, Lin F, Fu W, Liu S, Wang C, Liang J, Fan X, Ye X, Tang Y, Ding M, Yang Y, Lei C, Hu S.

FASEB J. 2019 Mar 18:fj201802354R. doi: 10.1096/fj.201802354R. [Epub ahead of print]

PMID:
30885011
2.

Cardiac adenovirus-associated viral Presenilin 1 gene delivery protects the left ventricular function of the heart via regulating RyR2 function in post-ischaemic heart failure.

Li T, Shen Y, Su L, Fan X, Lin F, Ye X, Ding D, Tang Y, Yang Y, Lei C, Hu S.

J Drug Target. 2018 Dec;26(10):895-904. doi: 10.1080/1061186X.2018.1450412. Epub 2018 Mar 21.

PMID:
29521549
3.

Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, Ellenberger D, Förster A, Schmitto JD, Gummert J, Schöndube FA, Hasenfuss G, Maier LS, Sossalla S.

Circulation. 2013 Aug 27;128(9):970-81. doi: 10.1161/CIRCULATIONAHA.113.001746. Epub 2013 Jul 19.

PMID:
23877259
4.

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.

Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RHA, Koch WJ, Katus HA, Most P.

Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93. Epub 2015 May 25.

5.

JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium.

Sacherer M, Sedej S, Wakuła P, Wallner M, Vos MA, Kockskämper J, Stiegler P, Sereinigg M, von Lewinski D, Antoons G, Pieske BM, Heinzel FR; CONTICA investigators.

Br J Pharmacol. 2012 Oct;167(3):493-504. doi: 10.1111/j.1476-5381.2012.01995.x.

6.

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM.

Circ Res. 2005 Dec 9;97(12):1314-22. Epub 2005 Nov 3.

PMID:
16269653
7.

A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.

Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M.

PLoS One. 2015 Jan 23;10(1):e0114314. doi: 10.1371/journal.pone.0114314. eCollection 2015.

8.

Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure.

Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S.

Circ Res. 2008 Dec 5;103(12):1466-72. doi: 10.1161/CIRCRESAHA.108.184457. Epub 2008 Nov 13.

9.

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function.

Belevych AE, Terentyev D, Terentyeva R, Nishijima Y, Sridhar A, Hamlin RL, Carnes CA, Györke S.

Cardiovasc Res. 2011 Jun 1;90(3):493-502. doi: 10.1093/cvr/cvr025. Epub 2011 Jan 27.

10.

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.

Shan J, Betzenhauser MJ, Kushnir A, Reiken S, Meli AC, Wronska A, Dura M, Chen BX, Marks AR.

J Clin Invest. 2010 Dec;120(12):4375-87. doi: 10.1172/JCI37649. Epub 2010 Nov 22.

11.

Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol.

Reiken S, Gaburjakova M, Guatimosim S, Gomez AM, D'Armiento J, Burkhoff D, Wang J, Vassort G, Lederer WJ, Marks AR.

J Biol Chem. 2003 Jan 3;278(1):444-53. Epub 2002 Oct 24.

12.

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.

Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2010 Sep 1;87(4):609-17. doi: 10.1093/cvr/cvq108. Epub 2010 Apr 13.

13.

The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca2+ leak in ventricular myocytes.

Bovo E, Huke S, Blatter LA, Zima AV.

J Mol Cell Cardiol. 2017 Mar;104:9-16. doi: 10.1016/j.yjmcc.2017.01.015. Epub 2017 Jan 25.

14.

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

Most P, Pleger ST, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ.

J Clin Invest. 2004 Dec;114(11):1550-63.

15.

High-mobility group box 1 (HMGB1) impaired cardiac excitation-contraction coupling by enhancing the sarcoplasmic reticulum (SR) Ca(2+) leak through TLR4-ROS signaling in cardiomyocytes.

Zhang C, Mo M, Ding W, Liu W, Yan D, Deng J, Luo X, Liu J.

J Mol Cell Cardiol. 2014 Sep;74:260-73. doi: 10.1016/j.yjmcc.2014.06.003. Epub 2014 Jun 14.

PMID:
24937603
16.

Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.

Reilly-O'Donnell B, Robertson GB, Karumbi A, McIntyre C, Bal W, Nishi M, Takeshima H, Stewart AJ, Pitt SJ.

J Biol Chem. 2017 Aug 11;292(32):13361-13373. doi: 10.1074/jbc.M117.781708. Epub 2017 Jun 19.

17.

ß-blocker timolol prevents arrhythmogenic Ca²⁺ release and normalizes Ca²⁺ and Zn²⁺ dyshomeostasis in hyperglycemic rat heart.

Tuncay E, Okatan EN, Vassort G, Turan B.

PLoS One. 2013 Jul 29;8(7):e71014. doi: 10.1371/journal.pone.0071014. Print 2013.

18.

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.

Walweel K, Molenaar P, Imtiaz MS, Denniss A, Dos Remedios C, van Helden DF, Dulhunty AF, Laver DR, Beard NA.

J Mol Cell Cardiol. 2017 Mar;104:53-62. doi: 10.1016/j.yjmcc.2017.01.016. Epub 2017 Jan 26.

PMID:
28131631
19.

Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.

Sedej S, Schmidt A, Denegri M, Walther S, Matovina M, Arnstein G, Gutschi EM, Windhager I, Ljubojević S, Negri S, Heinzel FR, Bisping E, Vos MA, Napolitano C, Priori SG, Kockskämper J, Pieske B.

J Am Coll Cardiol. 2014 Apr 22;63(15):1569-79. doi: 10.1016/j.jacc.2013.11.010. Epub 2013 Dec 4.

20.

PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity.

Ullrich ND, Valdivia HH, Niggli E.

J Mol Cell Cardiol. 2012 Jul;53(1):33-42. doi: 10.1016/j.yjmcc.2012.03.015. Epub 2012 Apr 1.

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