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Items: 1 to 20 of 94

1.

Phosphodiesterase-4 inhibition attenuates murine ulcerative colitis via interfering with mucosal immunity.

Li H, Fan C, Feng C, Wu Y, Lu H, He P, Yang X, Zhu F, Qi Q, Gao Y, Zuo J, Tang W.

Br J Pharmacol. 2019 Mar 18. doi: 10.1111/bph.14667. [Epub ahead of print]

PMID:
30883697
2.

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

Schafer PH, Truzzi F, Parton A, Wu L, Kosek J, Zhang LH, Horan G, Saltari A, Quadri M, Lotti R, Marconi A, Pincelli C.

Cell Signal. 2016 Jul;28(7):753-63. doi: 10.1016/j.cellsig.2016.01.007. Epub 2016 Jan 22.

4.

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity.

Schafer PH, Parton A, Capone L, Cedzik D, Brady H, Evans JF, Man HW, Muller GW, Stirling DI, Chopra R.

Cell Signal. 2014 Sep;26(9):2016-29. doi: 10.1016/j.cellsig.2014.05.014. Epub 2014 May 29.

5.

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.

Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY.

Cell Signal. 2008 May;20(5):803-14. doi: 10.1016/j.cellsig.2007.12.011. Epub 2007 Dec 28.

PMID:
18276108
6.

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.

Perez-Aso M, Montesinos MC, Mediero A, Wilder T, Schafer PH, Cronstein B.

Arthritis Res Ther. 2015 Sep 15;17:249. doi: 10.1186/s13075-015-0771-6.

7.

Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice.

Zhao H, Zhang H, Wu H, Li H, Liu L, Guo J, Li C, Shih DQ, Zhang X.

BMC Gastroenterol. 2012 May 30;12:57.

8.

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hänze J, Kolosionek E, Wilhelm J, Braun T, Grimminger F, Seeger W, Schermuly RT, Savai R.

Oncogene. 2013 Feb 28;32(9):1121-34. doi: 10.1038/onc.2012.136. Epub 2012 Apr 23.

PMID:
22525277
9.

Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-κB activation on dextran sulfate sodium-induced ulcerative colitis in mice.

Huang YF, Zhou JT, Qu C, Dou YX, Huang QH, Lin ZX, Xian YF, Xie JH, Xie YL, Lai XP, Su ZR.

J Ethnopharmacol. 2017 Feb 23;198:389-398. doi: 10.1016/j.jep.2017.01.042. Epub 2017 Jan 22.

PMID:
28119098
10.

Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice.

Yu XT, Xu YF, Huang YF, Qu C, Xu LQ, Su ZR, Zeng HF, Zheng L, Yi TG, Li HL, Chen JP, Zhang XJ.

PLoS One. 2018 Mar 14;13(3):e0194069. doi: 10.1371/journal.pone.0194069. eCollection 2018.

11.

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

McCann FE, Palfreeman AC, Andrews M, Perocheau DP, Inglis JJ, Schafer P, Feldmann M, Williams RO, Brennan FM.

Arthritis Res Ther. 2010;12(3):R107. doi: 10.1186/ar3041. Epub 2010 Jun 2.

12.

Cathelicidin-BF, a Novel Antimicrobial Peptide from Bungarus fasciatus, Attenuates Disease in a Dextran Sulfate Sodium Model of Colitis.

Zhang H, Xia X, Han F, Jiang Q, Rong Y, Song D, Wang Y.

Mol Pharm. 2015 May 4;12(5):1648-61. doi: 10.1021/acs.molpharmaceut.5b00069. Epub 2015 Apr 2.

PMID:
25807257
13.

Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages.

Maier C, Ramming A, Bergmann C, Weinkam R, Kittan N, Schett G, Distler JHW, Beyer C.

Ann Rheum Dis. 2017 Jun;76(6):1133-1141. doi: 10.1136/annrheumdis-2016-210189. Epub 2017 Feb 16.

PMID:
28209630
14.

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases.

Li H, Zuo J, Tang W.

Front Pharmacol. 2018 Oct 17;9:1048. doi: 10.3389/fphar.2018.01048. eCollection 2018. Review.

15.

Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP.

El-Ashmawy NE, Khedr NF, El-Bahrawy HA, El-Adawy SA.

Int Immunopharmacol. 2018 Mar;56:36-42. doi: 10.1016/j.intimp.2018.01.004. Epub 2018 Jan 10.

PMID:
29331766
17.

Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation.

Uo M, Hisamatsu T, Miyoshi J, Kaito D, Yoneno K, Kitazume MT, Mori M, Sugita A, Koganei K, Matsuoka K, Kanai T, Hibi T.

Gut. 2013 Dec;62(12):1734-44. doi: 10.1136/gutjnl-2012-303063. Epub 2012 Sep 26.

PMID:
23013725
18.

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice.

Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM Jr, Wilson KT, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G504-14. doi: 10.1152/ajpgi.00312.2011. Epub 2011 Dec 15.

20.

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