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The role of NUDT21 in microRNA-binging sites of EZH2 gene increases the of risk preeclampsia.

Lang X, Zhao W, Huang D, Liu W, Shen H, Xu L, Xu S, Huang Y, Cheng W.

J Cell Mol Med. 2019 Mar 18. doi: 10.1111/jcmm.14179. [Epub ahead of print]


NUDT21 regulates 3'-UTR length and microRNA-mediated gene silencing in hepatocellular carcinoma.

Sun M, Ding J, Li D, Yang G, Cheng Z, Zhu Q.

Cancer Lett. 2017 Dec 1;410:158-168. doi: 10.1016/j.canlet.2017.09.026. Epub 2017 Sep 28.


MicroRNA-30a-3p is overexpressed in the placentas of patients with preeclampsia and affects trophoblast invasion and apoptosis by its effects on IGF-1.

Niu ZR, Han T, Sun XL, Luan LX, Gou WL, Zhu XM.

Am J Obstet Gynecol. 2018 Feb;218(2):249.e1-249.e12. doi: 10.1016/j.ajog.2017.11.568. Epub 2017 Nov 16.


NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression.

Tan S, Li H, Zhang W, Shao Y, Liu Y, Guan H, Wu J, Kang Y, Zhao J, Yu Q, Gu Y, Ding K, Zhang M, Qian W, Zhu Y, Cai H, Chen C, Lobie PE, Zhao X, Sun J, Zhu T.

Oncogene. 2018 Aug;37(35):4887-4900. doi: 10.1038/s41388-018-0280-6. Epub 2018 May 21.


Up-regulation of miR-299 suppressed the invasion and migration of HTR-8/SVneo trophoblast cells partly via targeting HDAC2 in pre-eclampsia.

Gao Y, She R, Wang Q, Li Y, Zhang H.

Biomed Pharmacother. 2018 Jan;97:1222-1228. doi: 10.1016/j.biopha.2017.11.053. Epub 2017 Nov 13.


NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation.

Gennarino VA, Alcott CE, Chen CA, Chaudhury A, Gillentine MA, Rosenfeld JA, Parikh S, Wheless JW, Roeder ER, Horovitz DD, Roney EK, Smith JL, Cheung SW, Li W, Neilson JR, Schaaf CP, Zoghbi HY.

Elife. 2015 Aug 27;4. doi: 10.7554/eLife.10782.


Knockdown of NUDT21 inhibits proliferation and promotes apoptosis of human K562 leukemia cells through ERK pathway.

Zhang L, Zhang W.

Cancer Manag Res. 2018 Oct 8;10:4311-4323. doi: 10.2147/CMAR.S173496. eCollection 2018.


miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and in a model of angiogenesis defects related to inflammation.

Yang M, Chen Y, Chen L, Wang K, Pan T, Liu X, Xu W.

Placenta. 2016 May;41:62-73. doi: 10.1016/j.placenta.2016.03.007. Epub 2016 Mar 14.


Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients.

Chu Y, Elrod N, Wang C, Li L, Chen T, Routh A, Xia Z, Li W, Wagner EJ, Ji P.

Oncogene. 2019 Jan 31. doi: 10.1038/s41388-019-0714-9. [Epub ahead of print]


Downregulated lncRNA HOXA11-AS Affects Trophoblast Cell Proliferation and Migration by Regulating RND3 and HOXA7 Expression in PE.

Xu Y, Wu D, Liu J, Huang S, Zuo Q, Xia X, Jiang Y, Wang S, Chen Y, Wang T, Sun L.

Mol Ther Nucleic Acids. 2018 Sep 7;12:195-206. doi: 10.1016/j.omtn.2018.05.007. Epub 2018 May 29.


Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 11;172(1-2):106-120.e21. doi: 10.1016/j.cell.2017.11.023. Epub 2017 Dec 14. Erratum in: Cell. 2018 Jan 25;172(3):629-631.


Down-regulation of microRNA-34a-5p promotes trophoblast cell migration and invasion via targetting Smad4.

Xue F, Yang J, Li Q, Zhou H.

Biosci Rep. 2019 Feb 12;39(2). pii: BSR20181631. doi: 10.1042/BSR20181631. Print 2019 Feb 28.


MiRNA-26a Contributes to the Acquisition of Malignant Behaviors of Doctaxel-Resistant Lung Adenocarcinoma Cells through Targeting EZH2.

Chen J, Xu Y, Tao L, Pan Y, Zhang K, Wang R, Chen LB, Chu X.

Cell Physiol Biochem. 2017;41(2):583-597. doi: 10.1159/000457879. Epub 2017 Feb 3.


MicroRNA-454 is involved in regulating trophoblast cell proliferation, apoptosis, and invasion in preeclampsia by modulating the expression of ephrin receptor B4.

Wang F, Yan J.

Biomed Pharmacother. 2018 Nov;107:746-753. doi: 10.1016/j.biopha.2018.08.055. Epub 2018 Aug 20.


Expression and role of microRNA 18b and hypoxia inducible factor-1α in placental tissues of preeclampsia patients.

Wang S, Wang X, Weng Z, Zhang S, Ning H, Li B.

Exp Ther Med. 2017 Nov;14(5):4554-4560. doi: 10.3892/etm.2017.5067. Epub 2017 Aug 30.


MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2.

Zhang JG, Guo JF, Liu DL, Liu Q, Wang JJ.

J Thorac Oncol. 2011 Apr;6(4):671-8. doi: 10.1097/JTO.0b013e318208eb35.


SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells.

Koumangoye RB, Andl T, Taubenslag KJ, Zilberman ST, Taylor CJ, Loomans HA, Andl CD.

Mol Cancer. 2015 Feb 3;14:24. doi: 10.1186/s12943-014-0284-y.


EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma.

Li CH, Xiao Z, Tong JH, To KF, Fang X, Cheng AS, Chen Y.

Int J Cancer. 2017 Jan 1;140(1):120-129. doi: 10.1002/ijc.30414. Epub 2016 Sep 19.


A potential regulatory network among WDR86-AS1, miR-10b-3p, and LITAF is possibly involved in preeclampsia pathogenesis.

Li R, Wang N, Xue M, Long W, Cheng C, Mi C, Gao Z.

Cell Signal. 2019 Mar;55:40-52. doi: 10.1016/j.cellsig.2018.12.006. Epub 2018 Dec 12.


MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity.

Xu L, Beckebaum S, Iacob S, Wu G, Kaiser GM, Radtke A, Liu C, Kabar I, Schmidt HH, Zhang X, Lu M, Cicinnati VR.

J Hepatol. 2014 Mar;60(3):590-8. doi: 10.1016/j.jhep.2013.10.028. Epub 2013 Nov 6.


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