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The Tissue Distribution of Four Major Coumarins after Oral Administration of Angelicae Pubescentis Radix Extract to Rats Using Ultra-High-Performance Liquid Chromatography.

Ge Y, Chen S, Luo Q, Wang CP, Hao J, He J, Chen X, Yang X, Li J, Chang YX.

Evid Based Complement Alternat Med. 2019 Feb 7;2019:2365697. doi: 10.1155/2019/2365697. eCollection 2019.


Simultaneous assessment of absorption characteristics of coumarins from Angelicae Pubescentis Radix: In vitro transport across Caco-2 cell and in vivo pharmacokinetics in rats after oral administration.

Yang YF, Zhang L, Zhang YB, Yang XW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Aug 15;1060:308-315. doi: 10.1016/j.jchromb.2017.06.020. Epub 2017 Jun 13.


Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract.

Chang YX, Zhang QH, Li J, Zhang L, Guo XR, He J, Zhang P, Ma L, Deng YR, Zhang BL, Gao XM.

J Pharm Biomed Anal. 2013 Apr 15;77:71-5. doi: 10.1016/j.jpba.2012.12.031. Epub 2013 Jan 5.


Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MS/MS: Application to Pharmacokinetics of Columbianadin after Oral Administration.

Li J, Li Z, Luo Q, Wang CP, He J, Pang X, Teye Azietaku J, Chang YX.

Evid Based Complement Alternat Med. 2018 Sep 19;2018:8568303. doi: 10.1155/2018/8568303. eCollection 2018.


Ultra high performance liquid chromatography with photodiode array detector and quadrupole time-of-flight tandem mass spectrometry coupled with discriminant analysis to evaluate Angelicae pubescentis radix from different regions.

Ge AH, Ma WF, Wang CP, Li J, He J, Liu EW, Adelakum TA, Zhang BL, Gao X, Chang YX.

J Sep Sci. 2014 Sep;37(18):2523-34. doi: 10.1002/jssc.201400289. Epub 2014 Aug 8.


LC-MS/MS determination and pharmacokinetic study of columbianadin in rat plasma after intravenous administration of pure columbianadin.

Chang YX, Wang CP, Li J, Bai Y, Luo Q, He J, Lu B, Wang T, Zhang BL, Gao XM.

Chem Cent J. 2014 Nov 21;8(1):64. doi: 10.1186/s13065-014-0064-1. eCollection 2014.


The pharmacokinetics and oral bioavailability studies of columbianetin in rats after oral and intravenous administration.

Luo Q, Wang CP, Li J, Ma WF, Bai Y, Ma L, Gao XM, Zhang BL, Chang YX.

J Ethnopharmacol. 2013 Oct 28;150(1):175-80. doi: 10.1016/j.jep.2013.08.030. Epub 2013 Aug 28.


An UPLC-MS/MS method for simultaneous quantitation of two coumarins and two flavonoids in rat plasma and its application to a pharmacokinetic study of Wikstroemia indica extract.

Wei L, Wang X, Zhang P, Sun Y, Jia L, Zhao J, Dong S, Sun L.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:139-145. doi: 10.1016/j.jchromb.2015.11.034. Epub 2015 Nov 22.


Pharmacokinetics and tissue distribution study of prucalopride in rats by ultra high performance liquid chromatography with tandem mass spectrometry.

Zuo L, Sun Z, Wang Z, Du S, Kong X, Li L, Yang J, Kang J, Zhang X.

J Pharm Biomed Anal. 2016 Nov 30;131:246-255. doi: 10.1016/j.jpba.2016.08.030. Epub 2016 Aug 28.


Tissue distribution study of columbianadin and its active metabolite columbianetin in rats.

Zhang YB, Yang XW.

Biomed Chromatogr. 2016 Feb;30(2):256-62. doi: 10.1002/bmc.3543. Epub 2015 Aug 17.


A Diol-Based-Matrix Solid-Phase Dispersion Method for the Simultaneous Extraction and Determination of 13 Compounds From Angelicae Pubescentis Radix by Ultra High-Performance Liquid Chromatography.

Ding M, Bai Y, Li J, Yang X, Wang H, Gao X, Chang YX.

Front Pharmacol. 2019 Mar 8;10:227. doi: 10.3389/fphar.2019.00227. eCollection 2019.


Simultaneous determination of bioactive components of Radix Angelicae Sinensis-Radix Paeoniae Alba herb couple in rat plasma and tissues by UPLC-MS/MS and its application to pharmacokinetics and tissue distribution.

Luo N, Li Z, Qian D, Qian Y, Guo J, Duan JA, Zhu M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jul 15;963:29-39. doi: 10.1016/j.jchromb.2014.05.036. Epub 2014 May 27.


Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer-An in Vitro Model for Blood-Brain Barrier Permeability.

Yang YF, Xu W, Song W, Ye M, Yang XW.

Molecules. 2015 Jun 25;20(7):11719-32. doi: 10.3390/molecules200711719.


Determination of geniposide in adjuvant arthritis rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry method and its application to oral bioavailability and plasma protein binding ability studies.

Chen J, Wu H, Xu GB, Dai MM, Hu SL, Sun LL, Wang W, Wang R, Li SP, Li GQ.

J Pharm Biomed Anal. 2015 Apr 10;108:122-8. doi: 10.1016/j.jpba.2015.01.044. Epub 2015 Feb 7.


Simultaneous determination of seven coumarins by UPLC-MS/MS: Application to a comparative pharmacokinetic study in normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan or single-herb extract.

Wu Y, Wang F, Ai Y, Ma W, Bian Q, Lee DY, Dai R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 1;991:108-17. doi: 10.1016/j.jchromb.2015.04.017. Epub 2015 Apr 18.


Simultaneous determination of icariin, naringin and osthole in rat plasma by UPLC-MS/MS and its application for pharmacokinetic study after oral administration of Gushudan capsules.

Lu Y, Li N, Deng Y, Zhao L, Guo X, Li F, Xiong Z.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 1;993-994:75-80. doi: 10.1016/j.jchromb.2015.04.021. Epub 2015 May 6.


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