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27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells.

Chen S, Zhou C, Yu H, Tao L, An Y, Zhang X, Wang Y, Wang Y, Xiao R.

Front Mol Neurosci. 2019 Mar 1;12:14. doi: 10.3389/fnmol.2019.00014. eCollection 2019.


The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells.

Wang H, Yuan L, Ma W, Han J, Lu Y, Feng L, Xiao R.

Neurosci Lett. 2016 Oct 6;632:209-17. doi: 10.1016/j.neulet.2016.08.056. Epub 2016 Aug 31.


Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.

He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J.

Cell Res. 2015 Dec;25(12):1285-98. doi: 10.1038/cr.2015.139. Epub 2015 Nov 27.


Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells.

Nagakannan P, Eftekharpour E.

Free Radic Biol Med. 2017 Jul;108:819-831. doi: 10.1016/j.freeradbiomed.2017.05.005. Epub 2017 May 3.


NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.

Katsnelson MA, Lozada-Soto KM, Russo HM, Miller BA, Dubyak GR.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C83-C100. doi: 10.1152/ajpcell.00298.2015. Epub 2016 May 11.


Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.

Nakazawa T, Miyanoki Y, Urano Y, Uehara M, Saito Y, Noguchi N.

J Steroid Biochem Mol Biol. 2017 May;169:69-76. doi: 10.1016/j.jsbmb.2016.03.003. Epub 2016 Mar 4.


Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells.

Song XB, Liu G, Liu F, Yan ZG, Wang ZY, Liu ZP, Wang L.

Cell Death Dis. 2017 Jun 8;8(6):e2863. doi: 10.1038/cddis.2017.262.


Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity.

Jessop F, Hamilton RF Jr, Rhoderick JF, Fletcher P, Holian A.

Toxicol Appl Pharmacol. 2017 Mar 1;318:58-68. doi: 10.1016/j.taap.2017.01.012. Epub 2017 Jan 24.


Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms.

Kim LA, Amarnani D, Gnanaguru G, Tseng WA, Vavvas DG, D'Amore PA.

Invest Ophthalmol Vis Sci. 2014 Jul 3;55(8):4747-58. doi: 10.1167/iovs.13-13662.


Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides.

Russo HM, Rathkey J, Boyd-Tressler A, Katsnelson MA, Abbott DW, Dubyak GR.

J Immunol. 2016 Aug 15;197(4):1353-67. doi: 10.4049/jimmunol.1600699. Epub 2016 Jul 6.


Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.

Ono H, Ohta R, Kawasaki Y, Niwa A, Takada H, Nakahata T, Ohga S, Saito MK.

Inflamm Res. 2018 Oct;67(10):879-889. doi: 10.1007/s00011-018-1178-z. Epub 2018 Aug 22.


Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins.

Cermak S, Kosicek M, Mladenovic-Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S.

PLoS One. 2016 Nov 30;11(11):e0167428. doi: 10.1371/journal.pone.0167428. eCollection 2016.


[NLRP3 inflammasome induces pyroptosis in lung tissues of radiation-induced lung injury in mice].

Han R, Wu D, Deng S, Liu T, Zhang T, Xu Y.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Sep;33(9):1206-1211. Chinese.


(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization.

Zhang Y, Yang ND, Zhou F, Shen T, Duan T, Zhou J, Shi Y, Zhu XQ, Shen HM.

PLoS One. 2012;7(10):e46749. doi: 10.1371/journal.pone.0046749. Epub 2012 Oct 8.


Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death.

Lima H Jr, Jacobson LS, Goldberg MF, Chandran K, Diaz-Griffero F, Lisanti MP, Brojatsch J.

Cell Cycle. 2013 Jun 15;12(12):1868-78. doi: 10.4161/cc.24903. Epub 2013 May 20.


Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F.

Nature. 2015 Oct 29;526(7575):660-5. doi: 10.1038/nature15514. Epub 2015 Sep 16.


Lysosomal membrane permeabilization in cell death.

Boya P, Kroemer G.

Oncogene. 2008 Oct 27;27(50):6434-51. doi: 10.1038/onc.2008.310. Review.


Bradykinin B2 receptors play a neuroprotective role in Hypoxia/reoxygenation injury related to pyroptosis pathway.

Tang M, Li X, Liu P, Wang J, He F, Zhu X.

Curr Neurovasc Res. 2018;15(2):138-144. doi: 10.2174/1567202615666180528073141.


Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11.

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