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A novel PPAR alpha/gamma dual agonist inhibits cell growth and induces apoptosis in human glioblastoma T98G cells.

Liu DC, Zang CB, Liu HY, Possinger K, Fan SG, Elstner E.

Acta Pharmacol Sin. 2004 Oct;25(10):1312-9.


Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18.

Liu H, Zang C, Fenner MH, Liu D, Possinger K, Koeffler HP, Elstner E.

Blood. 2006 May 1;107(9):3683-92. Epub 2006 Jan 10.


Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells.

Zang C, Liu H, Bertz J, Possinger K, Koeffler HP, Elstner E, Eucker J.

Mol Cancer Ther. 2009 Aug;8(8):2296-307. doi: 10.1158/1535-7163.MCT-09-0347. Epub 2009 Aug 11.


Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines.

Zang C, Liu H, Waechter M, Eucker J, Bertz J, Possinger K, Koeffler HP, Elstner E.

Cell Cycle. 2006 Oct;5(19):2237-43. Epub 2006 Oct 1.


[Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism].

Zhang M, Zou P, Bai M, Tao XN, Jin Y, Guo R.

Zhonghua Yi Xue Za Zhi. 2003 Jul 10;83(13):1169-72. Chinese.


Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells.

Takeuchi S, Okumura T, Motomura W, Nagamine M, Takahashi N, Kohgo Y.

Jpn J Cancer Res. 2002 Jul;93(7):774-82.


Dual PPARα/γ ligand TZD18 improves myocardial metabolic remodeling after myocardial infarction in rats.

Chen XL, Liu ZR, Xue YJ, Chen X.

Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5765-5773. doi: 10.26355/eurrev_201712_14023.


A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis.

Guo Q, Sahoo SP, Wang PR, Milot DP, Ippolito MC, Wu MS, Baffic J, Biswas C, Hernandez M, Lam MH, Sharma N, Han W, Kelly LJ, MacNaul KL, Zhou G, Desai R, Heck JV, Doebber TW, Berger JP, Moller DE, Sparrow CP, Chao YS, Wright SD.

Endocrinology. 2004 Apr;145(4):1640-8. Epub 2003 Dec 30.


Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia.

Chen Y, Chen H, Birnbaum Y, Nanhwan MK, Bajaj M, Ye Y, Qian J.

Diab Vasc Dis Res. 2017 Mar;14(2):152-162. doi: 10.1177/1479164116679081. Epub 2017 Jan 23.


Apoptotic Mechanisms of Peroxisome Proliferator-Activated Receptor-γ Activation in Acinar Cells During Acute Pancreatitis.

Xu P, Lou XL, Chen C.

Pancreas. 2016 Feb;45(2):179-86. doi: 10.1097/MPA.0000000000000495.


The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo.

Wang XZ, Cheng Y, Wu H, Li N, Liu R, Yang XL, Qiu YY, Wen HM, Liang JY.

Phytomedicine. 2016 Jul 15;23(8):818-27. doi: 10.1016/j.phymed.2016.04.001. Epub 2016 May 11.


Down-regulation of peroxisome proliferator-activated receptor gamma in human cervical carcinoma.

Jung TI, Baek WK, Suh SI, Jang BC, Song DK, Bae JH, Kwon KY, Bae JH, Cha SD, Bae I, Cho CH.

Gynecol Oncol. 2005 May;97(2):365-73.


Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway.

Kim EJ, Park KS, Chung SY, Sheen YY, Moon DC, Song YS, Kim KS, Song S, Yun YP, Lee MK, Oh KW, Yoon DY, Hong JT.

J Pharmacol Exp Ther. 2003 Nov;307(2):505-17. Epub 2003 Sep 9.


Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway.

Sun KW, Ma YY, Guan TP, Xia YJ, Shao CM, Chen LG, Ren YJ, Yao HB, Yang Q, He XJ.

World J Gastroenterol. 2012 Dec 28;18(48):7166-74. doi: 10.3748/wjg.v18.i48.7166.


Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.

Konopleva M, Elstner E, McQueen TJ, Tsao T, Sudarikov A, Hu W, Schober WD, Wang RY, Chism D, Kornblau SM, Younes A, Collins SJ, Koeffler HP, Andreeff M.

Mol Cancer Ther. 2004 Oct;3(10):1249-62.


PPAR gamma ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells.

Nagamine M, Okumura T, Tanno S, Sawamukai M, Motomura W, Takahashi N, Kohgo Y.

Cancer Sci. 2003 Apr;94(4):338-43.

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