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Korean Red ginseng extract inhibits glioblastoma propagation by blocking the Wnt signaling pathway.

Ham SW, Kim JK, Jeon HY, Kim EJ, Jin X, Eun K, Park CG, Lee SY, Seo S, Kim JY, Choi SH, Hong N, Lee YY, Kim H.

J Ethnopharmacol. 2019 May 23;236:393-400. doi: 10.1016/j.jep.2019.03.031. Epub 2019 Mar 13.


20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.

Chen Z, Wei X, Shen L, Zhu H, Zheng X.

Cancer Sci. 2019 Jan;110(1):389-400. doi: 10.1111/cas.13881. Epub 2018 Dec 14.


Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: comparison between white and red ginseng.

Fishbein AB, Wang CZ, Li XL, Mehendale SR, Sun S, Aung HH, Yuan CS.

Arch Pharm Res. 2009 Apr;32(4):505-13. doi: 10.1007/s12272-009-1405-9. Epub 2009 Apr 29.


Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells.

Kim KH, Seol HJ, Kim EH, Rheey J, Jin HJ, Lee Y, Joo KM, Lee J, Nam DH.

Neuro Oncol. 2013 Feb;15(2):161-71. doi: 10.1093/neuonc/nos299. Epub 2012 Dec 20.


Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells.

Iglesia RP, Prado MB, Cruz L, Martins VR, Santos TG, Lopes MH.

Stem Cell Res Ther. 2017 Apr 17;8(1):76. doi: 10.1186/s13287-017-0518-1.


Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling.

He BC, Gao JL, Luo X, Luo J, Shen J, Wang L, Zhou Q, Wang YT, Luu HH, Haydon RC, Wang CZ, Du W, Yuan CS, He TC, Zhang BQ.

Int J Oncol. 2011 Feb;38(2):437-45. doi: 10.3892/ijo.2010.858. Epub 2010 Dec 3.


Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways.

Lee JH, Min DS, Lee CW, Song KH, Kim YS, Kim HP.

J Ginseng Res. 2018 Oct;42(4):476-484. doi: 10.1016/j.jgr.2017.05.005. Epub 2017 Jun 8.


Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.

Signore M, Pelacchi F, di Martino S, Runci D, Biffoni M, Giannetti S, Morgante L, De Majo M, Petricoin EF, Stancato L, Larocca LM, De Maria R, Pallini R, Ricci-Vitiani L.

Cell Death Dis. 2014 May 8;5:e1223. doi: 10.1038/cddis.2014.188.


Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.

De Robertis A, Valensin S, Rossi M, Tunici P, Verani M, De Rosa A, Giordano C, Varrone M, Nencini A, Pratelli C, Benicchi T, Bakker A, Hill J, Sangthongpitag K, Pendharkar V, Liu B, Ng FM, Then SW, Jing Tai S, Cheong SM, He X, Caricasole A, Salerno M.

Mol Cancer Ther. 2013 Jul;12(7):1180-9. doi: 10.1158/1535-7163.MCT-12-1176-T. Epub 2013 Apr 25.


Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration.

Clark PA, Bhattacharya S, Elmayan A, Darjatmoko SR, Thuro BA, Yan MB, van Ginkel PR, Polans AS, Kuo JS.

J Neurosurg. 2017 May;126(5):1448-1460. doi: 10.3171/2016.1.JNS152077. Epub 2016 Jul 15.


Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cells.

Conti S, Vexler A, Edry-Botzer L, Kalich-Philosoph L, Corn BW, Shtraus N, Meir Y, Hagoel L, Shtabsky A, Marmor S, Earon G, Lev-Ari S.

PLoS One. 2018 Jul 3;13(7):e0198627. doi: 10.1371/journal.pone.0198627. eCollection 2018.


Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma.

Lan F, Pan Q, Yu H, Yue X.

J Neurochem. 2015 Sep;134(5):811-8. doi: 10.1111/jnc.13174. Epub 2015 Jun 11.


Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model.

Kim TW, Choi HJ, Kim NJ, Kim DH.

Planta Med. 2009 Jun;75(8):836-9. doi: 10.1055/s-0029-1185402. Epub 2009 Mar 5.


BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence.

Jeon HY, Park CG, Ham SW, Choi SH, Lee SY, Kim JY, Seo S, Jin X, Kim JK, Eun K, Kim EJ, Kim H.

J Med Food. 2017 Sep;20(9):838-845. doi: 10.1089/jmf.2017.3929. Epub 2017 Aug 9.


Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells.

Dong Y, Han Q, Zou Y, Deng Z, Lu X, Wang X, Zhang W, Jin H, Su J, Jiang T, Ren H.

Mol Cell Biochem. 2012 Nov;370(1-2):89-102. doi: 10.1007/s11010-012-1401-0. Epub 2012 Jul 25.


Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice.

Lim CY, Moon JM, Kim BY, Lim SH, Lee GS, Yu HS, Cho SI.

J Ginseng Res. 2015 Jan;39(1):38-45. doi: 10.1016/j.jgr.2014.07.004. Epub 2014 Aug 1.


Generation of ginsenosides Rg3 and Rh2 from North American ginseng.

Popovich DG, Kitts DD.

Phytochemistry. 2004 Feb;65(3):337-44.


Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway.

Cilibrasi C, Riva G, Romano G, Cadamuro M, Bazzoni R, Butta V, Paoletta L, Dalprà L, Strazzabosco M, Lavitrano M, Giovannoni R, Bentivegna A.

PLoS One. 2017 Jan 12;12(1):e0169854. doi: 10.1371/journal.pone.0169854. eCollection 2017.


Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation.

Jeong D, Irfan M, Kim SD, Kim S, Oh JH, Park CK, Kim HK, Rhee MH.

J Ginseng Res. 2017 Oct;41(4):548-555. doi: 10.1016/j.jgr.2016.11.003. Epub 2017 Jan 13.


Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine-fructose.

Lee KH, Bae IY, Park SI, Park JD, Lee HG.

J Ginseng Res. 2016 Jul;40(3):237-44. doi: 10.1016/j.jgr.2015.08.002. Epub 2015 Aug 12.

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