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Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway.

Zhang H, Wei X, Lu S, Lin X, Huang J, Chen L, Huang X, Jiang L, Li Y, Qin L, Wei J, Huang R.

Biomed Pharmacother. 2019 May;113:108705. doi: 10.1016/j.biopha.2019.108705. Epub 2019 Mar 13.


Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway.

Xie Q, Zhang S, Chen C, Li J, Wei X, Xu X, Xuan F, Chen N, Pham T, Qin N, He J, Ye F, Huang W, Huang R, Wen Q.

Cell Physiol Biochem. 2016;39(5):1705-1715. Epub 2016 Sep 19.


Smad Anchor for Receptor Activation Regulates High Glucose-Induced EMT via Modulation of Smad2 and Smad3 Activities in Renal Tubular Epithelial Cells.

Tang WB, Ling GH, Sun L, Zhang K, Zhu X, Zhou X, Liu FY.

Nephron. 2015;130(3):213-20. doi: 10.1159/000431105. Epub 2015 Jul 4.


High Uric Acid-Induced Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via the TLR4/NF-kB Signaling Pathway.

Liu H, Xiong J, He T, Xiao T, Li Y, Yu Y, Huang Y, Xu X, Huang Y, Zhang J, Zhang B, Zhao J.

Am J Nephrol. 2017;46(4):333-342. doi: 10.1159/000481668. Epub 2017 Oct 10.


Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on High-Fat Diet-Induced Obesity and Insulin Resistance in Mice.

Li J, Wei X, Xie Q, Hoa Pham TT, Wei J, He P, Jiao Y, Xu X, Giang Nguyen TH, Wen Q, Huang R.

Cell Physiol Biochem. 2016;40(5):993-1004. Epub 2016 Dec 7.


The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.

Gao Y, Huang R, Gong Y, Park HS, Wen Q, Almosnid NM, Chippada-Venkata UD, Hosain NA, Vick E, Farone A, Altman E.

Oncotarget. 2015 Sep 15;6(27):24304-19.


Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease.

Wei X, Xu X, Chen Z, Liang T, Wen Q, Qin N, Huang W, Huang X, Li Y, Li J, He J, Wei J, Huang R.

Cell Physiol Biochem. 2018;49(3):1064-1073. doi: 10.1159/000493289. Epub 2018 Sep 7.


miR302a-3p May Modulate Renal Epithelial-Mesenchymal Transition in Diabetic Kidney Disease by Targeting ZEB1.

Tang WB, Zheng L, Yan R, Yang J, Ning J, Peng L, Zhou Q, Chen L.

Nephron. 2018;138(3):231-242. doi: 10.1159/000481465. Epub 2017 Dec 8.


Protective Effect of Znt7 on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells.

Zhang X, Lian X, Liang D, Zhang L, Liu S, Yang L, Chi ZH, Gu HF.

Kidney Blood Press Res. 2018;43(2):500-512. doi: 10.1159/000488697. Epub 2018 Mar 29.


Effect of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice.

Zheng N, Lin X, Wen Q, Kintoko, Zhang S, Huang J, Xu X, Huang R.

Toxicol Lett. 2013 May 10;219(1):77-84. doi: 10.1016/j.toxlet.2013.03.001. Epub 2013 Mar 13.


Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy.

Lu Q, Ji XJ, Zhou YX, Yao XQ, Liu YQ, Zhang F, Yin XX.

Pharmacol Res. 2015 Sep;99:237-47. doi: 10.1016/j.phrs.2015.06.006. Epub 2015 Jul 4.


Gremlin-mediated decrease in bone morphogenetic protein signaling promotes aristolochic acid-induced epithelial-to-mesenchymal transition (EMT) in HK-2 cells.

Li Y, Wang Z, Wang S, Zhao J, Zhang J, Huang Y.

Toxicology. 2012 Jul 16;297(1-3):68-75. doi: 10.1016/j.tox.2012.04.004. Epub 2012 Apr 15.


miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy.

Sun Z, Ma Y, Chen F, Wang S, Chen B, Shi J.

Eur J Pharmacol. 2018 Oct 15;837:96-104. doi: 10.1016/j.ejphar.2018.08.022. Epub 2018 Aug 17.


Allicin inhibits tubular epithelial-myofibroblast transdifferentiation under high glucose conditions in vitro.

Huang H, Zheng F, Dong X, Wu F, Wu T, Li H.

Exp Ther Med. 2017 Jan;13(1):254-262. doi: 10.3892/etm.2016.3913. Epub 2016 Nov 18.


Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro.

Wang QL, Tao YY, Yuan JL, Shen L, Liu CH.

BMC Cell Biol. 2010 May 5;11:31. doi: 10.1186/1471-2121-11-31.


Triptolide Attenuates Renal Tubular Epithelial-mesenchymal Transition Via the MiR-188-5p-mediated PI3K/AKT Pathway in Diabetic Kidney Disease.

Xue M, Cheng Y, Han F, Chang Y, Yang Y, Li X, Chen L, Lu Y, Sun B, Chen L.

Int J Biol Sci. 2018 Sep 7;14(11):1545-1557. doi: 10.7150/ijbs.24032. eCollection 2018.


Down-regulation of miR-23a inhibits high glucose-induced EMT and renal fibrogenesis by up-regulation of SnoN.

Xu H, Sun F, Li X, Sun L.

Hum Cell. 2018 Jan;31(1):22-32. doi: 10.1007/s13577-017-0180-z. Epub 2017 Jul 13.


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