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4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress.

Ma T, Zheng Z, Guo H, Lian X, Rane MJ, Cai L, Kim KS, Kim KT, Zhang Z, Bi L.

Toxicol Appl Pharmacol. 2019 May 1;370:93-105. doi: 10.1016/j.taap.2019.03.007. Epub 2019 Mar 12.


Magnolia bioactive constituent 4-O-methylhonokiol prevents the impairment of cardiac insulin signaling and the cardiac pathogenesis in high-fat diet-induced obese mice.

Zhang Z, Chen J, Zhou S, Wang S, Cai X, Conklin DJ, Kim KS, Kim KH, Tan Y, Zheng Y, Kim YH, Cai L.

Int J Biol Sci. 2015 Jun 5;11(8):879-91. doi: 10.7150/ijbs.12101. eCollection 2015.


The magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in mice.

Zhang Z, Chen J, Jiang X, Wang J, Yan X, Zheng Y, Conklin DJ, Kim KS, Kim KH, Tan Y, Kim YH, Cai L.

Oxid Med Cell Longev. 2014;2014:965954. doi: 10.1155/2014/965954. Epub 2014 May 29.


Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway.

Ji X, Li C, Ou Y, Li N, Yuan K, Yang G, Chen X, Yang Z, Liu B, Cheung WW, Wang L, Huang R, Lan T.

Mol Cell Endocrinol. 2016 Dec 5;437:268-279. doi: 10.1016/j.mce.2016.06.029. Epub 2016 Jul 1.


Extracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic Nephropathy.

Hong YA, Lim JH, Kim MY, Kim Y, Park HS, Kim HW, Choi BS, Chang YS, Kim HW, Kim TY, Park CW.

Antioxid Redox Signal. 2018 Jun 10;28(17):1543-1561. doi: 10.1089/ars.2017.7207. Epub 2017 Nov 14.


Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.

Zhang Z, Wang S, Zhou S, Yan X, Wang Y, Chen J, Mellen N, Kong M, Gu J, Tan Y, Zheng Y, Cai L.

J Mol Cell Cardiol. 2014 Dec;77:42-52. doi: 10.1016/j.yjmcc.2014.09.022. Epub 2014 Sep 28.


Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.

Yang WJ, Li YR, Gao H, Wu XY, Wang XL, Wang XN, Xiang L, Ren DM, Lou HX, Shen T.

J Ethnopharmacol. 2018 Dec 5;227:166-175. doi: 10.1016/j.jep.2018.08.037. Epub 2018 Sep 1.


Attenuation of diabetic nephropathy by Sanziguben Granule inhibiting EMT through Nrf2-mediated anti-oxidative effects in streptozotocin (STZ)-induced diabetic rats.

Zhang C, Li Q, Lai S, Yang L, Shi G, Wang Q, Luo Z, Zhao R, Yu Y.

J Ethnopharmacol. 2017 Jun 9;205:207-216. doi: 10.1016/j.jep.2017.05.009. Epub 2017 May 10.


Multiple low-dose radiation prevents type 2 diabetes-induced renal damage through attenuation of dyslipidemia and insulin resistance and subsequent renal inflammation and oxidative stress.

Shao M, Lu X, Cong W, Xing X, Tan Y, Li Y, Li X, Jin L, Wang X, Dong J, Jin S, Zhang C, Cai L.

PLoS One. 2014 Mar 20;9(3):e92574. doi: 10.1371/journal.pone.0092574. eCollection 2014.


Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells.

Ahad A, Ahsan H, Mujeeb M, Siddiqui WA.

Chem Biol Interact. 2015 Oct 5;240:292-303. doi: 10.1016/j.cbi.2015.08.026. Epub 2015 Sep 1.


Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice.

Chou YJ, Kan WC, Chang CM, Peng YJ, Wang HY, Yu WC, Cheng YH, Jhang YR, Liu HW, Chuu JJ.

Int J Mol Sci. 2016 Sep 13;17(9). pii: E1535. doi: 10.3390/ijms17091535.


Danshen injection ameliorates STZ-induced diabetic nephropathy in association with suppression of oxidative stress, pro-inflammatory factors and fibrosis.

Xu L, Shen P, Bi Y, Chen J, Xiao Z, Zhang X, Wang Z.

Int Immunopharmacol. 2016 Sep;38:385-94. doi: 10.1016/j.intimp.2016.06.024. Epub 2016 Jun 26.


Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy.

Cheng Y, Zhang J, Guo W, Li F, Sun W, Chen J, Zhang C, Lu X, Tan Y, Feng W, Fu Y, Liu GC, Xu Z, Cai L.

Free Radic Biol Med. 2016 Apr;93:94-109. doi: 10.1016/j.freeradbiomed.2016.02.002. Epub 2016 Feb 2.


RANKL-induced osteoclastogenesis is suppressed by 4-O-methylhonokiol in bone marrow-derived macrophages.

Park KR, Kim JY, Kim EC, Yun HM, Hong JT.

Arch Pharm Res. 2017 Aug;40(8):933-942. doi: 10.1007/s12272-017-0932-z. Epub 2017 Jul 24.


Protective Effects of Curcumin on Renal Oxidative Stress and Lipid Metabolism in a Rat Model of Type 2 Diabetic Nephropathy.

Kim BH, Lee ES, Choi R, Nawaboot J, Lee MY, Lee EY, Kim HS, Chung CH.

Yonsei Med J. 2016 May;57(3):664-73. doi: 10.3349/ymj.2016.57.3.664.


6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db/db mice.

Xu Y, Bai L, Chen X, Li Y, Qin Y, Meng X, Zhang Q.

Biomed Pharmacother. 2018 Jan;97:633-641. doi: 10.1016/j.biopha.2017.10.084. Epub 2017 Nov 6.


Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways.

Malik S, Suchal K, Khan SI, Bhatia J, Kishore K, Dinda AK, Arya DS.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F414-F422. doi: 10.1152/ajprenal.00393.2016. Epub 2017 May 31.


Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD.

Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar.


Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats.

Khanra R, Bhattacharjee N, Dua TK, Nandy A, Saha A, Kalita J, Manna P, Dewanjee S.

Biomed Pharmacother. 2017 Oct;94:726-741. doi: 10.1016/j.biopha.2017.07.112. Epub 2017 Aug 9.


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