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Cardioprotective effects of constitutively active MEK1 against H2O2-induced apoptosis and autophagy in cardiomyocytes via the ERK1/2 signaling pathway.

Sun MH, Chen XC, Han M, Yang YN, Gao XM, Ma X, Huang Y, Li XM, Gai MT, Liu F, Ma YT, Chen BD.

Biochem Biophys Res Commun. 2019 Apr 23;512(1):125-130. doi: 10.1016/j.bbrc.2019.03.008. Epub 2019 Mar 12.


Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes.

Yang YN, Ji WN, Ma YT, Li XM, Chen BD, Xiang Y, Liu F.

Genet Mol Res. 2012 Dec 21;11(4):4672-81. doi: 10.4238/2012.October.17.1.


Autophagy is involved in the protective effect of endophilin A2 on H2O2-induced apoptosis in H9C2 cardiomyocytes.

Liu Y, Liu HQ, Xiao JY, Ma KT, Wang XQ, Shen HJ, Luo JD.

Biochem Biophys Res Commun. 2018 May 5;499(2):299-306. doi: 10.1016/j.bbrc.2018.03.151. Epub 2018 Mar 24.


Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation.

Yin Y, Guan Y, Duan J, Wei G, Zhu Y, Quan W, Guo C, Zhou D, Wang Y, Xi M, Wen A.

Eur J Pharmacol. 2013 Jan 15;699(1-3):219-26. doi: 10.1016/j.ejphar.2012.11.005. Epub 2012 Nov 29.


25-Hydroxyl-protopanaxatriol protects against H2O2-induced H9c2 cardiomyocytes injury via PI3K/Akt pathway and apoptotic protein down-regulation.

Wang Z, Su G, Zhang Z, Dong H, Wang Y, Zhao H, Zhao Y, Sun Q.

Biomed Pharmacother. 2018 Mar;99:33-42. doi: 10.1016/j.biopha.2018.01.039. Epub 2018 Jan 8.


Cardioprotective effect of KR-33889, a novel PARP inhibitor, against oxidative stress-induced apoptosis in H9c2 cells and isolated rat hearts.

Park ES, Kang DH, Kang JC, Jang YC, Lee MJ, Chung HJ, Yi KY, Kim DE, Kim B, Shin HS.

Arch Pharm Res. 2017 May;40(5):640-654. doi: 10.1007/s12272-017-0912-3. Epub 2017 Apr 4.


Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After Exposure to Hypoxia and Oxidative Stress via Upregulating Cell Autophagy.

Zhu HH, Wang XT, Sun YH, He WK, Liang JB, Mo BH, Li L.

Cell Physiol Biochem. 2018;49(6):2138-2150. doi: 10.1159/000493817. Epub 2018 Sep 26.


Trimetazidine Protects Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Promoting AMP-activated Protein Kinase-dependent Autophagic Flux.

Zhong Y, Zhong P, He S, Zhang Y, Tang L, Ling Y, Fu S, Tang Y, Yang P, Luo T, Chen B, Chen A, Wang X.

J Cardiovasc Pharmacol. 2017 Jun;69(6):389-397. doi: 10.1097/FJC.0000000000000487.


FOXO1 silence aggravates oxidative stress-promoted apoptosis in cardiomyocytes by reducing autophagy.

Ning Y, Li Z, Qiu Z.

J Toxicol Sci. 2015;40(5):637-45. doi: 10.2131/jts.40.637.


The anti-apoptotic and cardioprotective effects of salvianolic acid a on rat cardiomyocytes following ischemia/reperfusion by DUSP-mediated regulation of the ERK1/2/JNK pathway.

Xu T, Wu X, Chen Q, Zhu S, Liu Y, Pan D, Chen X, Li D.

PLoS One. 2014 Jul 14;9(7):e102292. doi: 10.1371/journal.pone.0102292. eCollection 2014.


Tongxinluo exerts protective effects via anti-apoptotic and pro-autophagic mechanisms by activating AMPK pathway in infarcted rat hearts.

Li Q, Li N, Cui HH, Tian XQ, Jin C, Chen GH, Yang YJ.

Exp Physiol. 2017 Apr 1;102(4):422-435. doi: 10.1113/EP086192. Epub 2017 Mar 14.


Propofol attenuates H2O2-induced oxidative stress and apoptosis via the mitochondria- and ER-medicated pathways in neonatal rat cardiomyocytes.

Liu XR, Cao L, Li T, Chen LL, Yu YY, Huang WJ, Liu L, Tan XQ.

Apoptosis. 2017 May;22(5):639-646. doi: 10.1007/s10495-017-1349-3.


Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway.

Hu J, Cui W, Ding W, Gu Y, Wang Z, Fan W.

Cell Physiol Biochem. 2017;43(1):367-382. doi: 10.1159/000480416. Epub 2017 Aug 31.


Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide.

Liu P, Xiang JZ, Zhao L, Yang L, Hu BR, Fu Q.

Acta Pharmacol Sin. 2008 Jun;29(6):661-9. doi: 10.1111/j.1745-7254.2008.00794.x.


Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis.

Chen XG, Lv YX, Zhao D, Zhang L, Zheng F, Yang JY, Li XL, Wang L, Guo LY, Pan YM, Yan YW, Chen SY, Wang JN, Tang JM, Wan Y.

Mol Cell Biochem. 2016 Feb;413(1-2):9-23. doi: 10.1007/s11010-015-2622-9. Epub 2016 Jan 14.


Shengmai Injection Alleviates H2O2‑induced Oxidative Stress through Activation of AKT and Inhibition of ERK Pathways in Neonatal Rat Cardiomyocytes.

Zhu J, Ye Q, Xu S, Chang YX, Liu X, Ma Y, Zhu Y, Hua S.

J Ethnopharmacol. 2019 Jan 4. pii: S0378-8741(18)30846-8. doi: 10.1016/j.jep.2019.01.001. [Epub ahead of print]


Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway.

Wang Y, Li X, Wang X, Lau W, Wang Y, Xing Y, Zhang X, Ma X, Gao F.

PLoS One. 2013 Aug 16;8(8):e70956. doi: 10.1371/journal.pone.0070956. eCollection 2013.


PI3K/SGK1/GSK3β signaling pathway is involved in inhibition of autophagy in neonatal rat cardiomyocytes exposed to hypoxia/reoxygenation by hydrogen sulfide.

Jiang H, Xiao J, Kang B, Zhu X, Xin N, Wang Z.

Exp Cell Res. 2016 Jul 15;345(2):134-40. doi: 10.1016/j.yexcr.2015.07.005. Epub 2015 Jul 9.


Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling.

Lu Y, Feng Y, Liu D, Zhang Z, Gao K, Zhang W, Tang H.

Cell Physiol Biochem. 2018;47(3):1193-1206. doi: 10.1159/000490216. Epub 2018 Jun 15.


EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.

Lee JS, Kim SY, Kwon CH, Kim YK.

Arch Toxicol. 2006 Jun;80(6):337-46. Epub 2005 Dec 9.


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