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m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response.

Yu R, Li Q, Feng Z, Cai L, Xu Q.

Int J Mol Sci. 2019 Mar 15;20(6). pii: E1323. doi: 10.3390/ijms20061323.


MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein.

Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y, Zhang X.

J Biol Chem. 2017 Mar 3;292(9):3614-3623. doi: 10.1074/jbc.M116.749689. Epub 2017 Jan 19.


Xanthii fructus inhibits inflammatory responses in LPS-stimulated RAW 264.7 macrophages through suppressing NF-κB and JNK/p38 MAPK.

Yeom M, Kim JH, Min JH, Hwang MK, Jung HS, Sohn Y.

J Ethnopharmacol. 2015 Dec 24;176:394-401. doi: 10.1016/j.jep.2015.11.020. Epub 2015 Nov 10.


Anti-inflammatory effects of Phyllanthus amarus Schum. & Thonn. through inhibition of NF-κB, MAPK, and PI3K-Akt signaling pathways in LPS-induced human macrophages.

Harikrishnan H, Jantan I, Haque MA, Kumolosasi E.

BMC Complement Altern Med. 2018 Jul 25;18(1):224. doi: 10.1186/s12906-018-2289-3.


Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-κB and p38 MAPK pathways in LPS-activated RAW264.7 macrophages.

Pang M, Yuan Y, Wang D, Li T, Wang D, Shi X, Guo M, Wang C, Zhang X, Zheng G, Yu B, Wang H.

Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):435-443. doi: 10.1093/abbs/gmx020.


Anti-inflammatory effect of the six compounds isolated from Nauclea officinalis Pierrc ex Pitard, and molecular mechanism of strictosamide via suppressing the NF-κB and MAPK signaling pathway in LPS-induced RAW 264.7 macrophages.

Li D, Chen J, Ye J, Zhai X, Song J, Jiang C, Wang J, Zhang H, Jia X, Zhu F.

J Ethnopharmacol. 2017 Jan 20;196:66-74. doi: 10.1016/j.jep.2016.12.007. Epub 2016 Dec 15.


N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection.

Hesser CR, Karijolich J, Dominissini D, He C, Glaunsinger BA.

PLoS Pathog. 2018 Apr 16;14(4):e1006995. doi: 10.1371/journal.ppat.1006995. eCollection 2018 Apr.


Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways.

Dai JN, Zong Y, Zhong LM, Li YM, Zhang W, Bian LG, Ai QL, Liu YD, Sun J, Lu D.

PLoS One. 2011;6(7):e21891. doi: 10.1371/journal.pone.0021891. Epub 2011 Jul 12.


β-carotene attenuates lipopolysaccharide-induced inflammation via inhibition of the NF-κB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways in macrophages.

Li R, Hong P, Zheng X.

Anim Sci J. 2019 Jan;90(1):140-148. doi: 10.1111/asj.13108. Epub 2018 Nov 20.


Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels.

Li J, Meng S, Xu M, Wang S, He L, Xu X, Wang X, Xie L.

Oncotarget. 2017 Dec 18;9(3):3752-3764. doi: 10.18632/oncotarget.23365. eCollection 2018 Jan 9.


RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.

Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM.

Hepatology. 2018 Jun;67(6):2254-2270. doi: 10.1002/hep.29683. Epub 2018 Apr 19.


Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.

Zhang F, Kang Y, Wang M, Li Y, Xu T, Yang W, Song H, Wu H, Shu Q, Jin P.

Hum Mol Genet. 2018 Nov 15;27(22):3936-3950. doi: 10.1093/hmg/ddy292.


7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages.

Shao J, Li Y, Wang Z, Xiao M, Yin P, Lu Y, Qian X, Xu Y, Liu J.

Int Immunopharmacol. 2013 Oct;17(2):216-28. doi: 10.1016/j.intimp.2013.06.008. Epub 2013 Jun 26.


Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways.

Haque MA, Jantan I, Harikrishnan H.

Int Immunopharmacol. 2018 Feb;55:312-322. doi: 10.1016/j.intimp.2018.01.001. Epub 2018 Jan 5.


Modification of N6-methyladenosine RNA methylation on heat shock protein expression.

Yu J, Li Y, Wang T, Zhong X.

PLoS One. 2018 Jun 14;13(6):e0198604. doi: 10.1371/journal.pone.0198604. eCollection 2018.


Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.


Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-κB and MAPK pathways.

Dong J, Li J, Cui L, Wang Y, Lin J, Qu Y, Wang H.

BMC Vet Res. 2018 Jan 30;14(1):30. doi: 10.1186/s12917-018-1360-0.

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