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Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity.

Zhao Q, Zhang T, Xiao XR, Huang JF, Wang Y, Gonzalez FJ, Li F.

Br J Pharmacol. 2019 Mar 15. doi: 10.1111/bph.14664. [Epub ahead of print]


Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity.

Liu A, Krausz KW, Fang ZZ, Brocker C, Qu A, Gonzalez FJ.

Arch Toxicol. 2014 Apr;88(4):983-96. doi: 10.1007/s00204-013-1188-0. Epub 2014 Jan 3.


Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

Fang ZZ, Krausz KW, Tanaka N, Li F, Qu A, Idle JR, Gonzalez FJ.

Arch Toxicol. 2013 Nov;87(11):1975-1987. doi: 10.1007/s00204-013-1053-1. Epub 2013 Apr 11.


Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.

Li F, Patterson AD, Krausz KW, Tanaka N, Gonzalez FJ.

J Lipid Res. 2012 Aug;53(8):1625-35. doi: 10.1194/jlr.M027433. Epub 2012 Jun 4.


Metabolomic approach to understand the acute and chronic hepatotoxicity of Veratrum nigrum extract in mice based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Wei Z, Qian Q, Dong X, Li N, Sun G, Gao S, Dong X.

Toxicol Mech Methods. 2017 Nov;27(9):687-696. doi: 10.1080/15376516.2017.1351017. Epub 2017 Jul 28.


Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice.

Lu Y, Sun J, Petrova K, Yang X, Greenhaw J, Salminen WF, Beger RD, Schnackenberg LK.

Food Chem Toxicol. 2013 Dec;62:707-21. doi: 10.1016/j.fct.2013.09.025. Epub 2013 Sep 27.


Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver disease.

Li HH, Tyburski JB, Wang YW, Strawn S, Moon BH, Kallakury BV, Gonzalez FJ, Fornace AJ Jr.

Alcohol Clin Exp Res. 2014 Jun;38(6):1520-31. doi: 10.1111/acer.12424. Epub 2014 Apr 28.


Urine and plasma metabolomics study on potential hepatoxic biomarkers identification in rats induced by Gynura segetum.

Qiu S, Zhang H, Fei Q, Zhu F, Wang J, Jia X, Chen B.

J Ethnopharmacol. 2018 Apr 24;216:37-46. doi: 10.1016/j.jep.2018.01.017. Epub 2018 Jan 17.


Metabolic alterations in triptolide-induced acute hepatotoxicity.

Zhao J, Xie C, Mu X, Krausz KW, Patel DP, Shi X, Gao X, Wang Q, Gonzalez FJ.

Biomed Chromatogr. 2018 Oct;32(10):e4299. doi: 10.1002/bmc.4299. Epub 2018 Jul 4.


Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis.

Jeong ES, Kim G, Shin HJ, Park SM, Oh JH, Kim YB, Moon KS, Choi HK, Jeong J, Shin JG, Kim DH.

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):213-22. doi: 10.1016/j.taap.2015.07.016. Epub 2015 Jul 26.


Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity.

Shi X, Yao D, Gosnell BA, Chen C.

J Lipid Res. 2012 Nov;53(11):2318-30. doi: 10.1194/jlr.M027656. Epub 2012 Aug 19.


Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo.

Jensen BC, Parry TL, Huang W, Ilaiwy A, Bain JR, Muehlbauer MJ, O'Neal SK, Patterson C, Johnson GL, Willis MS.

Metabolites. 2017 Jun 22;7(3). pii: E31. doi: 10.3390/metabo7030031.


Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY.

Biochim Biophys Acta. 2015 Jan;1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 May 4.


Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis.

Zhang CE, Niu M, Li Q, Zhao YL, Ma ZJ, Xiong Y, Dong XP, Li RY, Feng WW, Dong Q, Ma X, Zhu Y, Zou ZS, Cao JL, Wang JB, Xiao XH.

J Ethnopharmacol. 2016 Dec 24;194:299-306. doi: 10.1016/j.jep.2016.09.011. Epub 2016 Sep 9.


Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats.

Zhang LF, Liu LS, Chu XM, Xie H, Cao LJ, Guo C, A JY, Cao B, Li MJ, Wang GJ, Hao HP.

Acta Pharmacol Sin. 2014 Mar;35(3):363-72. doi: 10.1038/aps.2013.135. Epub 2014 Jan 20.


Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.

Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ.

Hepatology. 2012 Jul;56(1):118-29. doi: 10.1002/hep.25630. Epub 2012 Jun 6.


Metabolites identification of harmane in vitro/in vivo in rats by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Li S, Liu W, Teng L, Cheng X, Wang Z, Wang C.

J Pharm Biomed Anal. 2014 Apr;92:53-62. doi: 10.1016/j.jpba.2014.01.003. Epub 2014 Jan 10.


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