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CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ25-35-induced neurotoxicity by inhibiting the pCRMP2/NMDAR2B signaling pathway.

Ji Y, Hu Y, Ren J, Khanna R, Yao Y, Chen Y, Li Q, Sun L.

Chem Biol Interact. 2019 Mar 12;305:28-39. doi: 10.1016/j.cbi.2019.03.005. [Epub ahead of print]


Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.

Moutal A, François-Moutal L, Brittain JM, Khanna M, Khanna R.

Front Cell Neurosci. 2015 Jan 26;8:471. doi: 10.3389/fncel.2014.00471. eCollection 2014.


Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.

Brustovetsky T, Pellman JJ, Yang XF, Khanna R, Brustovetsky N.

J Biol Chem. 2014 Mar 14;289(11):7470-82. doi: 10.1074/jbc.M113.518472. Epub 2014 Jan 28.


Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, Porreca F, Khanna R.

Pain. 2016 Sep;157(9):2124-40. doi: 10.1097/j.pain.0000000000000628.


Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2).

Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A, White FA, Zamponi GW, Brustovetsky N, Chen J, Khanna R.

J Biol Chem. 2011 Oct 28;286(43):37778-92. doi: 10.1074/jbc.M111.255455. Epub 2011 Aug 9.


A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.

François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R.

Pain. 2015 Jul;156(7):1247-64. doi: 10.1097/j.pain.0000000000000147.


Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells.

Wang Y, Miao Y, Mir AZ, Cheng L, Wang L, Zhao L, Cui Q, Zhao W, Wang H.

J Neurol Sci. 2016 Sep 15;368:223-30. doi: 10.1016/j.jns.2016.07.010. Epub 2016 Jul 11.


Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model.

Brittain JM, Pan R, You H, Brustovetsky T, Brustovetsky N, Zamponi GW, Lee WH, Khanna R.

Channels (Austin). 2012 Jan-Feb;6(1):52-9. doi: 10.4161/chan.18919. Epub 2012 Jan 1.


Neuroprotection against Aβ25-35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells.

Yu H, Yao L, Zhou H, Qu S, Zeng X, Zhou D, Zhou Y, Li X, Liu Z.

Neurochem Int. 2014 Sep;75:89-95. doi: 10.1016/j.neuint.2014.06.001. Epub 2014 Jun 13.


Genistein inhibits Aβ25-35 -induced SH-SY5Y cell damage by modulating the expression of apoptosis-related proteins and Ca2+ influx through ionotropic glutamate receptors.

Xu HN, Li LX, Wang YX, Wang HG, An D, Heng B, Liu YQ.

Phytother Res. 2019 Feb;33(2):431-441. doi: 10.1002/ptr.6239. Epub 2018 Nov 19.


Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ25-35-Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway.

Fu QQ, Wei L, Sierra J, Cheng JZ, Moreno-Flores MT, You H, Yu HR.

Cell Mol Neurobiol. 2017 Aug;37(6):1043-1054. doi: 10.1007/s10571-016-0437-1. Epub 2016 Nov 2.


An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25-35.

Zhang Y, Jiao G, Song C, Gu S, Brown RE, Zhang J, Zhang P, Gagnon J, Locke S, Stefanova R, Pelletier C, Zhang Y, Lu H.

Mar Drugs. 2017 Mar 22;15(3). pii: E83. doi: 10.3390/md15030083.


Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway.

Xue MQ, Liu XX, Zhang YL, Gao FG.

Int J Mol Med. 2014 Apr;33(4):925-33. doi: 10.3892/ijmm.2014.1632. Epub 2014 Jan 24.


Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R.

Br J Pharmacol. 2018 Jun;175(12):2244-2260. doi: 10.1111/bph.13737. Epub 2017 Mar 17.


Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.

Feldman P, Khanna R.

Neurosci Lett. 2013 Dec 17;557 Pt A:27-36. doi: 10.1016/j.neulet.2013.06.057. Epub 2013 Jul 3. Review.


Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide.

Ju W, Li Q, Allette YM, Ripsch MS, White FA, Khanna R.

J Neurochem. 2013 Mar;124(6):869-79. doi: 10.1111/jnc.12070. Epub 2013 Jan 20.


Genistein Inhibits Aβ25-35-Induced Synaptic Toxicity and Regulates CaMKII/CREB Pathway in SH-SY5Y Cells.

Xi YD, Zhang DD, Ding J, Yu HL, Yuan LH, Ma WW, Han J, Xiao R.

Cell Mol Neurobiol. 2016 Oct;36(7):1151-9. doi: 10.1007/s10571-015-0311-6. Epub 2015 Dec 11.


Novel squamosamide derivative (compound FLZ) attenuates Abeta25-35-induced toxicity in SH-SY5Y cells.

Fang F, Liu GT.

Acta Pharmacol Sin. 2008 Feb;29(2):152-60. doi: 10.1111/j.1745-7254.2008.00714.x.


[Effects of α3 neuronal nicotinic acetylcholine receptor on cell apoptosis and p38 MAPK signal transduction pathway in SH-SY5Y cells].

Zhang XL, Qi XL, Ren JM, Wu CX, Guan ZZ.

Zhonghua Bing Li Xue Za Zhi. 2013 Feb;42(2):116-20. doi: 10.3760/cma.j.issn.0529-5807.2013.02.010. Chinese.


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