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Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration.

Huang J, Gu S, Chen M, Zhang SJ, Jiang Z, Chen X, Jiang C, Liu G, Radu RA, Sun X, Vollrath D, Du J, Yan B, Zhao C.

Theranostics. 2019 Jan 30;9(4):1170-1180. doi: 10.7150/thno.26281. eCollection 2019.


Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.

Yao J, Jia L, Khan N, Lin C, Mitter SK, Boulton ME, Dunaief JL, Klionsky DJ, Guan JL, Thompson DA, Zacks DN.

Autophagy. 2015;11(6):939-53. doi: 10.1080/15548627.2015.1041699.


Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration.

Mao H, Seo SJ, Biswal MR, Li H, Conners M, Nandyala A, Jones K, Le YZ, Lewin AS.

Invest Ophthalmol Vis Sci. 2014 Jul 1;55(7):4613-27. doi: 10.1167/iovs.14-14633.


Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium.

Yu B, Egbejimi A, Dharmat R, Xu P, Zhao Z, Long B, Miao H, Chen R, Wensel TG, Cai J, Chen Y.

Sci Signal. 2018 May 29;11(532). pii: eaag3315. doi: 10.1126/scisignal.aag3315.


Conditional loss of Kcnj13 in the retinal pigment epithelium causes photoreceptor degeneration.

Roman D, Zhong H, Yaklichkin S, Chen R, Mardon G.

Exp Eye Res. 2018 Nov;176:219-226. doi: 10.1016/j.exer.2018.07.014. Epub 2018 Jul 25.


Choroidal thickness in retinal pigment epithelial tear as measured by spectral domain optical coherence tomography.

Bhavsar KV, Branchini L, Shah H, Regatieri CV, Duker JS.

Retina. 2014 Jan;34(1):63-8. doi: 10.1097/IAE.0b013e318297a061.


Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.

Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R, Dong A, Greenbaum S, Gu L, Sengupta S, Cano M, Hackett S, Xu G, Lutty GA, Dong L, Sergeev Y, Handa JT, Campochiaro P, Wawrousek E, Zigler JS Jr, Sinha D.

Autophagy. 2014 Mar;10(3):480-96. doi: 10.4161/auto.27292. Epub 2014 Jan 23.


Subretinal injection of amyloid-β peptide accelerates RPE cell senescence and retinal degeneration.

Liu C, Cao L, Yang S, Xu L, Liu P, Wang F, Xu D.

Int J Mol Med. 2015 Jan;35(1):169-76. doi: 10.3892/ijmm.2014.1993. Epub 2014 Nov 10.


Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.

Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, Marmorstein LY.

Mol Vis. 2017 Apr 14;23:228-241. eCollection 2017.


Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography.

Chen L, Zhang X, Gan Y, Liu B, Zhang Y, Wen F.

Graefes Arch Clin Exp Ophthalmol. 2018 Dec;256(12):2283-2291. doi: 10.1007/s00417-018-4138-y. Epub 2018 Sep 18.


The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.

Shang P, Valapala M, Grebe R, Hose S, Ghosh S, Bhutto IA, Handa JT, Lutty GA, Lu L, Wan J, Qian J, Sergeev Y, Puertollano R, Zigler JS Jr, Xu GT, Sinha D.

Aging Cell. 2017 Apr;16(2):349-359. doi: 10.1111/acel.12561. Epub 2017 Jan 13.


Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration.

Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A.

Oncotarget. 2016 Feb 23;7(8):8532-45. doi: 10.18632/oncotarget.7384.


Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium.

Dinculescu A, Min SH, Dyka FM, Deng WT, Stupay RM, Chiodo V, Smith WC, Hauswirth WW.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6971-80. doi: 10.1167/iovs.15-17166.


Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.

Tolmachova T, Wavre-Shapton ST, Barnard AR, MacLaren RE, Futter CE, Seabra MC.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4913-20. doi: 10.1167/iovs.09-4892. Epub 2010 May 5.


Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.

Yu B, Xu P, Zhao Z, Cai J, Sternberg P, Chen Y.

Invest Ophthalmol Vis Sci. 2014 Dec 9;55(12):8638-50. doi: 10.1167/iovs.14-14758.


3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling.

Li KR, Yang SQ, Gong YQ, Yang H, Li XM, Zhao YX, Yao J, Jiang Q, Cao C.

Sci Rep. 2016 May 6;6:25525. doi: 10.1038/srep25525.


mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

Zhao C, Yasumura D, Li X, Matthes M, Lloyd M, Nielsen G, Ahern K, Snyder M, Bok D, Dunaief JL, LaVail MM, Vollrath D.

J Clin Invest. 2011 Jan;121(1):369-83. doi: 10.1172/JCI44303. Epub 2010 Dec 6.


Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.

Milam AH, Curcio CA, Cideciyan AV, Saxena S, John SK, Kruth HS, Malek G, Heckenlively JR, Weleber RG, Jacobson SG.

Ophthalmology. 2000 Dec;107(12):2256-66.


Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice.

Huang H, Liu Y, Wang L, Li W.

PLoS One. 2017 Mar 10;12(3):e0173716. doi: 10.1371/journal.pone.0173716. eCollection 2017.

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