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Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species.

He K, Wu L, Ding Q, Haider F, Yu H, Wang H, Xiang G.

Oxid Med Cell Longev. 2019 Feb 4;2019:5152072. doi: 10.1155/2019/5152072. eCollection 2019.


Apatinib has anti-tumor effects and induces autophagy in colon cancer cells.

Lu W, Ke H, Qianshan D, Zhen W, Guoan X, Honggang Y.

Iran J Basic Med Sci. 2017 Sep;20(9):990-995. doi: 10.22038/IJBMS.2017.9263.


Apatinib Inhibits Angiogenesis Via Suppressing Akt/GSK3β/ANG Signaling Pathway in Anaplastic Thyroid Cancer.

Jin Z, Cheng X, Feng H, Kuang J, Yang W, Peng C, Shen B, Qiu W.

Cell Physiol Biochem. 2017;44(4):1471-1484. doi: 10.1159/000485583. Epub 2017 Dec 1.


Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.

Zhang H, Cao Y, Chen Y, Li G, Yu H.

Oncol Lett. 2018 Apr;15(4):5739-5743. doi: 10.3892/ol.2018.8031. Epub 2018 Feb 12.


Apatinib-induced protective autophagy and apoptosis through the AKT-mTOR pathway in anaplastic thyroid cancer.

Feng H, Cheng X, Kuang J, Chen L, Yuen S, Shi M, Liang J, Shen B, Jin Z, Yan J, Qiu W.

Cell Death Dis. 2018 Oct 9;9(10):1030. doi: 10.1038/s41419-018-1054-3.


Apatinib exerts anti-tumour effects on ovarian cancer cells.

Ding J, Cheng XY, Liu S, Ji HY, Lin M, Ma R, Meng FL.

Gynecol Oncol. 2019 Apr;153(1):165-174. doi: 10.1016/j.ygyno.2019.01.010. Epub 2019 Jan 14.


Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration.

Liu Z, Jia X, Duan Y, Xiao H, Sundqvist KG, Permert J, Wang F.

Cancer Biol Ther. 2013 May;14(5):428-35. doi: 10.4161/cbt.23786. Epub 2013 Feb 1.


2-Methoxyestradiol inhibits hypoxia-induced scleroderma fibroblast collagen synthesis by phosphatidylinositol 3-kinase/Akt/mTOR signalling.

Zhou X, Liu C, Lu J, Zhu L, Li M.

Rheumatology (Oxford). 2018 Sep 1;57(9):1675-1684. doi: 10.1093/rheumatology/key166.


Downregulation of HIF-1α inhibits the proliferation and invasion of non-small cell lung cancer NCI-H157 cells.

Qian J, Bai H, Gao Z, Dong YU, Pei J, Ma M, Han B.

Oncol Lett. 2016 Mar;11(3):1738-1744. Epub 2016 Jan 26.


GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways.

Burrows N, Babur M, Resch J, Ridsdale S, Mejin M, Rowling EJ, Brabant G, Williams KJ.

J Clin Endocrinol Metab. 2011 Dec;96(12):E1934-43. doi: 10.1210/jc.2011-1426. Epub 2011 Oct 12.


NADPH oxidase subunit p22(phox)-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer.

Li Q, Fu GB, Zheng JT, He J, Niu XB, Chen QD, Yin Y, Qian X, Xu Q, Wang M, Sun AF, Shu Y, Rui H, Liu LZ, Jiang BH.

Biochim Biophys Acta. 2013 Dec;1833(12):3375-3385. doi: 10.1016/j.bbamcr.2013.09.018. Epub 2013 Oct 8.


The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells.

Li H, Fan Y, Yang F, Zhao L, Cao B.

Oncol Lett. 2018 Jul;16(1):353-361. doi: 10.3892/ol.2018.8656. Epub 2018 May 7.


Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells.

Zhang E, Feng X, Liu F, Zhang P, Liang J, Tang X.

PLoS One. 2014 Jul 24;9(7):e103440. doi: 10.1371/journal.pone.0103440. eCollection 2014.


Centchroman regulates breast cancer angiogenesis via inhibition of HIF-1α/VEGFR2 signalling axis.

Dewangan J, Kaushik S, Rath SK, Balapure AK.

Life Sci. 2018 Jan 15;193:9-19. doi: 10.1016/j.lfs.2017.11.045. Epub 2017 Nov 28.


Combined aspirin and apatinib treatment suppresses gastric cancer cell proliferation.

Zhang W, Tan Y, Ma H.

Oncol Lett. 2017 Nov;14(5):5409-5417. doi: 10.3892/ol.2017.6858. Epub 2017 Aug 31.


[Inhibitory effect of apatinib on HL-60 cell proliferation and its mechanism].

Liang S, Tong XZ, Fu LW.

Nan Fang Yi Ke Da Xue Xue Bao. 2011 May;31(5):871-4. Chinese.


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