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Items: 1 to 20 of 101

1.

PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia/Lymphoma.

Chung EY, Mai Y, Shah UA, Wei Y, Ishida E, Kataoka K, Ren X, Pradhan K, Bartholdy B, Wei X, Zou Y, Zhang J, Ogawa S, Steidl U, Zang X, Verma A, Janakiram M, Ye BH.

Clin Cancer Res. 2019 Mar 12. doi: 10.1158/1078-0432.CCR-18-3033. [Epub ahead of print]

PMID:
30862694
2.

CADM1/TSLC1 is a novel cell surface marker for adult T-cell leukemia/lymphoma.

Nakahata S, Morishita K.

J Clin Exp Hematop. 2012;52(1):17-22. Review.

3.

A Preclinical Model for the ATLL Lymphoma Subtype With Insights Into the Role of Microenvironment in HTLV-1-Mediated Lymphomagenesis.

Vicario M, Mattiolo A, Montini B, Piano MA, Cavallari I, Amadori A, Chieco-Bianchi L, Calabrò ML.

Front Microbiol. 2018 Jun 13;9:1215. doi: 10.3389/fmicb.2018.01215. eCollection 2018.

4.

Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1.

Edlinger L, Berger-Becvar A, Menzl I, Hoermann G, Greiner G, Grundschober E, Bago-Horvath Z, Al-Zoughbi W, Hoefler G, Brostjan C, Gille L, Moriggl R, Spittler A, Sexl V, Hoelbl-Kovacic A.

Br J Haematol. 2017 Oct;179(2):229-241. doi: 10.1111/bjh.14833. Epub 2017 Jul 14.

5.

Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met.

Onimaru Y, Tsukasaki K, Murata K, Imaizumi Y, Choi YL, Hasegawa H, Sugahara K, Yamada Y, Hayashi T, Nakashima M, Taguchi T, Mano H, Kamihira S, Tomonaga M.

Int J Oncol. 2008 Oct;33(4):697-703.

PMID:
18813782
6.

Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.

Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.

J Clin Exp Hematop. 2017 Jul 5;57(1):15-20. doi: 10.3960/jslrt.17003. Epub 2017 Apr 18.

7.

Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.

Coniglio SJ, Zavarella S, Symons MH.

Mol Cell Biol. 2008 Jun;28(12):4162-72. doi: 10.1128/MCB.01532-07. Epub 2008 Apr 14.

8.

PAK1 and PAK2 have different roles in HGF-induced morphological responses.

Bright MD, Garner AP, Ridley AJ.

Cell Signal. 2009 Dec;21(12):1738-47. doi: 10.1016/j.cellsig.2009.07.005. Epub 2009 Jul 21.

PMID:
19628037
9.

Anti-adult T‑cell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor.

Ishikawa C, Senba M, Mori N.

Int J Oncol. 2018 Oct;53(4):1681-1690. doi: 10.3892/ijo.2018.4513. Epub 2018 Aug 1.

PMID:
30066853
10.
11.

Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.

Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

J Biol Chem. 2017 Jun 9;292(23):9523-9539. doi: 10.1074/jbc.M116.771394. Epub 2017 Apr 13.

12.

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.

Radu M, Lyle K, Hoeflich KP, Villamar-Cruz O, Koeppen H, Chernoff J.

Mol Cell Biol. 2015 Dec;35(23):3990-4005. doi: 10.1128/MCB.00630-15. Epub 2015 Sep 21.

13.

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.

Siu MK, Wong ES, Chan HY, Kong DS, Woo NW, Tam KF, Ngan HY, Chan QK, Chan DC, Chan KY, Cheung AN.

Int J Cancer. 2010 Jul 1;127(1):21-31. doi: 10.1002/ijc.25005.

14.

Clinicopathologic features of adult T-cell leukemias/lymphomas at a North American tertiary care medical center: infrequent involvement of the central nervous system.

Hsi AC, Kreisel FH, Frater JL, Nguyen TT.

Am J Surg Pathol. 2014 Feb;38(2):245-56. doi: 10.1097/PAS.0000000000000109. Review.

PMID:
24418858
15.

Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma.

Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K.

Leukemia. 2012 Jun;26(6):1238-46. doi: 10.1038/leu.2011.379. Epub 2012 Jan 6.

PMID:
22289924
16.

Association of p21-activated kinase-1 activity with aggressive tumor behavior and poor prognosis of head and neck cancer.

Park J, Kim JM, Park JK, Huang S, Kwak SY, Ryu KA, Kong G, Park J, Koo BS.

Head Neck. 2015 Jul;37(7):953-63. doi: 10.1002/hed.23695. Epub 2014 Jun 27.

PMID:
24634274
17.

Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma.

Ishii T, Ishida T, Utsunomiya A, Inagaki A, Yano H, Komatsu H, Iida S, Imada K, Uchiyama T, Akinaga S, Shitara K, Ueda R.

Clin Cancer Res. 2010 Mar 1;16(5):1520-31. doi: 10.1158/1078-0432.CCR-09-2697. Epub 2010 Feb 16.

18.

The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events.

Nuche-Berenguer B, Ramos-Álvarez I, Jensen RT.

Biochim Biophys Acta. 2016 Jun;1862(6):1122-36. doi: 10.1016/j.bbadis.2016.02.008. Epub 2016 Feb 18.

19.

HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions.

Tarokhian H, Rahimi H, Mosavat A, Shirdel A, Rafatpanah H, Akbarin MM, Bari A, Ramezani S, Rezaee SA.

BMC Cancer. 2018 Dec 22;18(1):1287. doi: 10.1186/s12885-018-5209-5.

20.

Molecular Pathology of Adult T-Cell Leukemia/Lymphoma.

Ohshima K.

Oncology. 2015;89 Suppl 1:7-15. doi: 10.1159/000431058. Epub 2015 Nov 10. Review.

PMID:
26550829

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