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Oral dosing of pentoxifylline, a pan-phosphodiesterase inhibitor restores bone mass and quality in osteopenic rabbits by an osteogenic mechanism: A comparative study with human parathyroid hormone.

Pal S, Porwal K, Khanna K, Gautam MK, Malik MY, Rashid M, Macleod RJ, Wahajuddin M, Parameswaran V, Bellare JR, Chattopadhyay N.

Bone. 2019 Mar 9;123:28-38. doi: 10.1016/j.bone.2019.03.010. [Epub ahead of print]


Odanacatib Restores Trabecular Bone of Skeletally Mature Female Rabbits With Osteopenia but Induces Brittleness of Cortical Bone: A Comparative Study of the Investigational Drug With PTH, Estrogen, and Alendronate.

Khan MP, Singh AK, Singh AK, Shrivastava P, Tiwari MC, Nagar GK, Bora HK, Parameswaran V, Sanyal S, Bellare JR, Chattopadhyay N.

J Bone Miner Res. 2016 Mar;31(3):615-29. doi: 10.1002/jbmr.2719. Epub 2015 Oct 26. Erratum in: J Bone Miner Res. 2015 Oct;30(10):1944. J Bone Miner Res. 2018 Nov;33(11):2084-2085.


A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat.

Smith BJ, Bu SY, Wang Y, Rendina E, Lim YF, Marlow D, Clarke SL, Cullen DM, Lucas EA.

Bone. 2014 Jan;58:151-9. doi: 10.1016/j.bone.2013.10.005. Epub 2013 Oct 11.


Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis.

Srivastava K, Tyagi AM, Khan K, Dixit M, Lahiri S, Kumar A, Changkija B, Khan MP, Nagar GK, Yadav DK, Maurya R, Singh SP, Jain GK, Wahajuddin, Trivedi R, Chattopadhyay N, Singh D.

Phytomedicine. 2013 Apr 15;20(6):470-80. doi: 10.1016/j.phymed.2012.12.021. Epub 2013 Feb 8.


Raloxifene and teriparatide (hPTH 1-34) have complementary effects on the osteopenic skeleton of ovariectomized rats.

Ma YL, Bryant HU, Zeng Q, Schmidt A, Jee WS, Sato M.

J Bone Miner Metab. 2005;23 Suppl:62-8.


A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia.

Ke HZ, Qi H, Crawford DT, Simmons HA, Xu G, Li M, Plum L, Clagett-Dame M, DeLuca HF, Thompson DD, Brown TA.

J Bone Miner Res. 2005 Oct;20(10):1742-55. Epub 2005 Jun 13.


Intermittent minodronic acid treatment with sufficient bone resorption inhibition prevents reduction in bone mass and strength in ovariectomized rats with established osteopenia comparable with daily treatment.

Kimoto A, Tanaka M, Nozaki K, Mori M, Fukushima S, Mori H, Shiroya T, Nakamura T.

Bone. 2013 Jul;55(1):189-97. doi: 10.1016/j.bone.2013.02.013. Epub 2013 Feb 26.


Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption.

Doyle N, Varela A, Haile S, Guldberg R, Kostenuik PJ, Ominsky MS, Smith SY, Hattersley G.

Osteoporos Int. 2018 Mar;29(3):685-697. doi: 10.1007/s00198-017-4323-6. Epub 2017 Dec 19.


Effect of the interaction of parathyroid hormone and cyclosporine a on bone mineral metabolism in the rat.

Epstein S, Dissanayake IR, Goodman GR, Bowman AR, Zhou H, Ma Y, Jee WS.

Calcif Tissue Int. 2001 Apr;68(4):240-7. Epub 2001 Apr 11.


Six Weeks of Daily Abaloparatide Treatment Increased Vertebral and Femoral Bone Mineral Density, Microarchitecture and Strength in Ovariectomized Osteopenic Rats.

Bahar H, Gallacher K, Downall J, Nelson CA, Shomali M, Hattersley G.

Calcif Tissue Int. 2016 Nov;99(5):489-499. Epub 2016 Jul 9.


Formononetin reverses established osteopenia in adult ovariectomized rats.

Tyagi AM, Srivastava K, Singh AK, Kumar A, Changkija B, Pandey R, Lahiri S, Nagar GK, Yadav DK, Maurya R, Trivedi R, Singh D.

Menopause. 2012 Aug;19(8):856-63. doi: 10.1097/gme.0b013e31824f9306.


One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption.

Varela A, Chouinard L, Lesage E, Smith SY, Hattersley G.

J Bone Miner Res. 2017 Jan;32(1):24-33. doi: 10.1002/jbmr.3003. Epub 2016 Oct 17.


Ulmus davidiana extract improves lumbar vertebral parameters in ovariectomized osteopenic rats.

Zhuang X, Fu C, Liu W, Wang Y, Xu F, Zhang Q, Liu Y, Liu Y.

Am J Transl Res. 2016 Feb 15;8(2):298-313. eCollection 2016.


A comparison of the effects of two anabolic agents (fluoride and PTH) on ash density and bone strength assessed in an osteopenic rat model.

S√łgaard CH, Mosekilde L, Thomsen JS, Richards A, McOsker JE.

Bone. 1997 May;20(5):439-49.


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