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Items: 1 to 20 of 101

1.

Penicisulfuranol A, a novel C-terminal inhibitor disrupting molecular chaperone function of Hsp90 independent of ATP binding domain.

Dai J, Chen A, Zhu M, Qi X, Tang W, Liu M, Li D, Gu Q, Li J.

Biochem Pharmacol. 2019 May;163:404-415. doi: 10.1016/j.bcp.2019.03.012. Epub 2019 Mar 8.

PMID:
30857829
2.

Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

Donnelly A, Blagg BS.

Curr Med Chem. 2008;15(26):2702-17. Review.

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6.

Structural studies on the co-chaperone Hop and its complexes with Hsp90.

Onuoha SC, Coulstock ET, Grossmann JG, Jackson SE.

J Mol Biol. 2008 Jun 13;379(4):732-44. doi: 10.1016/j.jmb.2008.02.013. Epub 2008 Feb 14.

PMID:
18485364
7.

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90.

Chadli A, Bouhouche I, Sullivan W, Stensgard B, McMahon N, Catelli MG, Toft DO.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12524-9.

8.

Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.

Cartledge K, Elsegood C, Roiniotis J, Hamilton JA, Scholz GM.

Biochemistry. 2007 Dec 25;46(51):15144-52. Epub 2007 Dec 1.

PMID:
18052042
9.

A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.

Armstrong HK, Koay YC, Irani S, Das R, Nassar ZD; Australian Prostate Cancer BioResource, Selth LA, Centenera MM, McAlpine SR, Butler LM.

Prostate. 2016 Dec;76(16):1546-1559. doi: 10.1002/pros.23239. Epub 2016 Aug 16.

PMID:
27526951
10.
11.

Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A.

Grover A, Shandilya A, Agrawal V, Pratik P, Bhasme D, Bisaria VS, Sundar D.

BMC Bioinformatics. 2011 Feb 15;12 Suppl 1:S30. doi: 10.1186/1471-2105-12-S1-S30.

13.

Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.

Ardi VC, Alexander LD, Johnson VA, McAlpine SR.

ACS Chem Biol. 2011 Dec 16;6(12):1357-66. doi: 10.1021/cb200203m. Epub 2011 Oct 17.

14.

Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones.

Chen F, Haigh S, Yu Y, Benson T, Wang Y, Li X, Dou H, Bagi Z, Verin AD, Stepp DW, Csanyi G, Chadli A, Weintraub NL, Smith SM, Fulton DJ.

Free Radic Biol Med. 2015 Dec;89:793-805. doi: 10.1016/j.freeradbiomed.2015.09.019. Epub 2015 Oct 9.

15.

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation.

Huang W, Ye M, Zhang LR, Wu QD, Zhang M, Xu JH, Zheng W.

Mol Cancer. 2014 Jun 14;13:150. doi: 10.1186/1476-4598-13-150.

16.

Stimulation of heat shock protein 90 chaperone function through binding of a novobiocin analog KU-32.

Chatterjee BK, Jayaraj A, Kumar V, Blagg B, Davis RE, Jayaram B, Deep S, Chaudhuri TK.

J Biol Chem. 2019 Feb 21. pii: jbc.RA118.002502. doi: 10.1074/jbc.RA118.002502. [Epub ahead of print]

17.

Chaperoning the chaperone: a role for the co-chaperone Cpr7 in modulating Hsp90 function in Saccharomyces cerevisiae.

Zuehlke AD, Johnson JL.

Genetics. 2012 Jul;191(3):805-14. doi: 10.1534/genetics.112.140319. Epub 2012 Apr 13.

18.

Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.

Yun BG, Huang W, Leach N, Hartson SD, Matts RL.

Biochemistry. 2004 Jun 29;43(25):8217-29.

PMID:
15209518
19.

Protein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity.

Rahimi MN, McAlpine SR.

Chem Commun (Camb). 2019 Jan 15;55(6):846-849. doi: 10.1039/c8cc07576j.

PMID:
30575826
20.

Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation.

Goode KM, Petrov DP, Vickman RE, Crist SA, Pascuzzi PE, Ratliff TL, Davisson VJ, Hazbun TR.

Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1992-2006. doi: 10.1016/j.bbagen.2017.05.006. Epub 2017 May 8.

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