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Items: 1 to 20 of 100

1.

Structure based virtual screening of novel noncompetitive antagonist  of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Duan ML, Tan LL, Du J, Yao XJ.

J Biotechnol. 2019 Apr 10;295:9-18. doi: 10.1016/j.jbiotec.2019.01.023. Epub 2019 Mar 1.

PMID:
30831124
2.

Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

Menniti FS, Chenard BL, Collins MB, Ducat MF, Elliott ML, Ewing FE, Huang JI, Kelly KA, Lazzaro JT, Pagnozzi MJ, Weeks JL, Welch WM, White WF.

Mol Pharmacol. 2000 Dec;58(6):1310-7.

PMID:
11093768
3.

Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors.

Kvist T, Greenwood JR, Hansen KB, Traynelis SF, Bräuner-Osborne H.

Neuropharmacology. 2013 Dec;75:324-36. doi: 10.1016/j.neuropharm.2013.08.003. Epub 2013 Aug 22.

4.

The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities.

Mellor IR.

Future Med Chem. 2010 May;2(5):877-91. doi: 10.4155/fmc.10.27. Review.

PMID:
21426207
5.
6.

Binding modes of noncompetitive AMPA antagonists: a computational approach.

De Luca L, Macchiarulo A, Costantino G, Barreca ML, Gitto R, Chimirri A, Pellicciari R.

Farmaco. 2003 Feb;58(2):107-13.

PMID:
12581776
7.

Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist.

Ohno K, Tsutsumi R, Matsumoto N, Yamashita H, Amada Y, Shishikura J, Yatsugi HI, Okada M, Sakamoto S, Yamaguchi T.

J Pharmacol Exp Ther. 2003 Jul;306(1):66-72. Epub 2003 Mar 26.

PMID:
12660313
8.

Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.

Krogsgaard-Larsen P, Ferkany JW, Nielsen EO, Madsen U, Ebert B, Johansen JS, Diemer NH, Bruhn T, Beattie DT, Curtis DR.

J Med Chem. 1991 Jan;34(1):123-30.

PMID:
1825114
10.

Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.

Zhao WQ, Santini F, Breese R, Ross D, Zhang XD, Stone DJ, Ferrer M, Townsend M, Wolfe AL, Seager MA, Kinney GG, Shughrue PJ, Ray WJ.

J Biol Chem. 2010 Mar 5;285(10):7619-32. doi: 10.1074/jbc.M109.057182. Epub 2009 Dec 23.

13.
14.

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

Gardinier KM, Gernert DL, Porter WJ, Reel JK, Ornstein PL, Spinazze P, Stevens FC, Hahn P, Hollinshead SP, Mayhugh D, Schkeryantz J, Khilevich A, De Frutos O, Gleason SD, Kato AS, Luffer-Atlas D, Desai PV, Swanson S, Burris KD, Ding C, Heinz BA, Need AB, Barth VN, Stephenson GA, Diseroad BA, Woods TA, Yu H, Bredt D, Witkin JM.

J Med Chem. 2016 May 26;59(10):4753-68. doi: 10.1021/acs.jmedchem.6b00125. Epub 2016 Apr 29.

PMID:
27067148
15.

The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2.

Ahmed AH, Hamada M, Shinada T, Ohfune Y, Weerasinghe L, Garner PP, Oswald RE.

J Biol Chem. 2012 Nov 30;287(49):41007-13. doi: 10.1074/jbc.M112.416362. Epub 2012 Oct 17.

16.
17.

Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist.

Hibi S, Ueno K, Nagato S, Kawano K, Ito K, Norimine Y, Takenaka O, Hanada T, Yonaga M.

J Med Chem. 2012 Dec 13;55(23):10584-600. doi: 10.1021/jm301268u. Epub 2012 Dec 4.

PMID:
23181587
18.

Discrimination between agonists and antagonists by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor. A mutation analysis of the ligand-binding domain of GluR-D subunit.

Lampinen M, Settimo L, Pentikainen OT, Jouppila A, Mottershead DG, Johnson MS, Keinanen K.

J Biol Chem. 2002 Nov 1;277(44):41940-7. Epub 2002 Aug 7.

19.

Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist.

Madsen U, Sløk FA, Stensbøl TB, Bräuner-Osborne H, Lützhøft HH, Poulsen MV, Eriksen L, Krogsgaard-Larsen P.

Eur J Med Chem. 2000 Jan;35(1):69-76.

PMID:
10733604
20.

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.

Frølund B, Greenwood JR, Holm MM, Egebjerg J, Madsen U, Nielsen B, Bräuner-Osborne H, Stensbøl TB, Krogsgaard-Larsen P.

Bioorg Med Chem. 2005 Sep 15;13(18):5391-8.

PMID:
16043357

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