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Items: 1 to 20 of 94


Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides.

Bargeton B, Iwaszkiewicz J, Bonifacio G, Roy S, Zoete V, Kellenberger S.

Sci Rep. 2019 Feb 22;9(1):2599. doi: 10.1038/s41598-018-37426-5.


Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a.

Salinas M, Besson T, Delettre Q, Diochot S, Boulakirba S, Douguet D, Lingueglia E.

J Biol Chem. 2014 May 9;289(19):13363-73. doi: 10.1074/jbc.M114.561076. Epub 2014 Apr 2.


The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.

Krauson AJ, Carattino MD.

J Biol Chem. 2016 May 20;291(21):11407-19. doi: 10.1074/jbc.M115.702316. Epub 2016 Mar 25.


Protonation controls ASIC1a activity via coordinated movements in multiple domains.

Bonifacio G, Lelli CI, Kellenberger S.

J Gen Physiol. 2014 Jan;143(1):105-18. doi: 10.1085/jgp.201311053. Epub 2013 Dec 16.


Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.

Frey EN, Pavlovicz RE, Wegman CJ, Li C, Askwith CC.

PLoS One. 2013 Aug 14;8(8):e71733. doi: 10.1371/journal.pone.0071733. eCollection 2013.


Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating.

Vullo S, Bonifacio G, Roy S, Johner N, Bernèche S, Kellenberger S.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3768-3773. doi: 10.1073/pnas.1620560114. Epub 2017 Mar 20.


Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse.

González-Inchauspe C, Urbano FJ, Di Guilmi MN, Uchitel OD.

J Neurosci. 2017 Mar 8;37(10):2589-2599. doi: 10.1523/JNEUROSCI.2566-16.2017. Epub 2017 Feb 3.


Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.

Gwiazda K, Bonifacio G, Vullo S, Kellenberger S.

J Biol Chem. 2015 Jul 17;290(29):17956-66. doi: 10.1074/jbc.M115.641688. Epub 2015 Jun 12.


ASICs and neuropeptides.

Vick JS, Askwith CC.

Neuropharmacology. 2015 Jul;94:36-41. doi: 10.1016/j.neuropharm.2014.12.012. Epub 2015 Jan 12. Review.


The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain.

Reiners M, Margreiter MA, Oslender-Bujotzek A, Rossetti G, Gründer S, Schmidt A.

Mol Pharmacol. 2018 Oct;94(4):1114-1124. doi: 10.1124/mol.118.112375. Epub 2018 Jul 16.


Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).

Schmidt A, Rossetti G, Joussen S, Gründer S.

Mol Pharmacol. 2017 Dec;92(6):665-675. doi: 10.1124/mol.117.110064. Epub 2017 Oct 12.


Functional characterization of acid-sensing ion channels in cultured neurons of rat inferior colliculus.

Zhang M, Gong N, Lu YG, Jia NL, Xu TL, Chen L.

Neuroscience. 2008 Jun 23;154(2):461-72. doi: 10.1016/j.neuroscience.2008.03.040. Epub 2008 Mar 26.


Acid-sensing ion channels are tuned to follow high-frequency stimuli.

MacLean DM, Jayaraman V.

J Physiol. 2016 May 15;594(10):2629-45. doi: 10.1113/JP271915. Epub 2016 Apr 10.


Expression and activity of acid-sensing ion channels in the mouse anterior pituitary.

Du J, Reznikov LR, Welsh MJ.

PLoS One. 2014 Dec 15;9(12):e115310. doi: 10.1371/journal.pone.0115310. eCollection 2014.


Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits.

Gautam M, Benson CJ.

FASEB J. 2013 Feb;27(2):793-802. doi: 10.1096/fj.12-220400. Epub 2012 Oct 29.


Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline.

Alijevic O, Kellenberger S.

J Biol Chem. 2012 Oct 19;287(43):36059-70. doi: 10.1074/jbc.M112.360487. Epub 2012 Sep 4.


Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.

Sherwood TW, Askwith CC.

J Biol Chem. 2008 Jan 25;283(4):1818-30. Epub 2007 Nov 5.


Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators.

Vyvers A, Schmidt A, Wiemuth D, Gründer S.

Sci Rep. 2018 Dec 20;8(1):18000. doi: 10.1038/s41598-018-36125-5.


Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ).

Besson T, Lingueglia E, Salinas M.

Neuropharmacology. 2017 Oct;125:429-440. doi: 10.1016/j.neuropharm.2017.08.004. Epub 2017 Aug 9.


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