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MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway.

Zou H, Chen Q, Zhang A, Wang S, Wu H, Yuan Y, Wang S, Yu J, Luo M, Wen X, Cui W, Fu W, Yu R, Chen L, Zhang M, Lan H, Zhang X, Xie Q, Jin G, Xu C.

Cell Death Dis. 2019 Feb 15;10(3):148. doi: 10.1038/s41419-019-1324-8.


Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma.

Tang XP, Chen Q, Li Y, Wang Y, Zou HB, Fu WJ, Niu Q, Pan QG, Jiang P, Xu XS, Zhang KQ, Liu H, Bian XW, Wu XF.

Lab Invest. 2019 Feb;99(2):191-199. doi: 10.1038/s41374-018-0138-0. Epub 2018 Oct 5.


Overexpression of MPC1 inhibits the proliferation, migration, invasion, and stem cell-like properties of gastric cancer cells.

Zhou X, Xiong ZJ, Xiao SM, Zhou J, Ding Z, Tang LC, Chen XD, Xu R, Zhao P.

Onco Targets Ther. 2017 Oct 24;10:5151-5163. doi: 10.2147/OTT.S148681. eCollection 2017.


Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma.

Ohashi T, Eguchi H, Kawamoto K, Konno M, Asai A, Colvin H, Ueda Y, Takaoka H, Iwagami Y, Yamada D, Asaoka T, Noda T, Wada H, Gotoh K, Kobayashi S, Koseki J, Satoh T, Ogawa K, Doki Y, Mori M, Ishii H.

Oncol Rep. 2018 Mar;39(3):1276-1282. doi: 10.3892/or.2017.6172. Epub 2017 Dec 20.


MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.

Wang L, Xu M, Qin J, Lin SC, Lee HJ, Tsai SY, Tsai MJ.

Oncotarget. 2016 Mar 22;7(12):14673-83. doi: 10.18632/oncotarget.7405.


Downregulation of COUP-TFII inhibits glioblastoma growth via targeting MPC1.

Xiao B, Fan Y, Ye M, Lv S, Xu B, Chai Y, Wu M, Zhu X.

Oncol Lett. 2018 Jun;15(6):9697-9702. doi: 10.3892/ol.2018.8601. Epub 2018 Apr 27.


MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis.

Koh E, Kim YK, Shin D, Kim KS.

Biochem J. 2018 May 18;475(10):1687-1699. doi: 10.1042/BCJ20170967.


MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer.

Li X, Ji Y, Han G, Li X, Fan Z, Li Y, Zhong Y, Cao J, Zhao J, Zhang M, Wen J, Goscinski MA, Nesland JM, Suo Z.

BMC Cancer. 2016 Nov 16;16(1):894.


MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.

Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC.

J Biol Chem. 2016 Aug 5;291(32):16448-61. doi: 10.1074/jbc.M116.733840. Epub 2016 Jun 17.


A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J.

Science. 2012 Jul 6;337(6090):96-100. doi: 10.1126/science.1218099. Epub 2012 May 24.


Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses.

Li X, Li Y, Han G, Li X, Ji Y, Fan Z, Zhong Y, Cao J, Zhao J, Mariusz G, Zhang M, Wen J, Nesland JM, Suo Z.

Oncotarget. 2016 Nov 29;7(48):79981-79994. doi: 10.18632/oncotarget.13210.


Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity.

Liang L, Li Q, Huang L, Li D, Li X.

Biochem Biophys Res Commun. 2015 Dec 25;468(4):807-12. doi: 10.1016/j.bbrc.2015.11.036. Epub 2015 Nov 11.


Fatty acid oxidation alleviates the energy deficiency caused by the loss of MPC1 in MPC1+/- mice.

Zou S, Lang T, Zhang B, Huang K, Gong L, Luo H, Xu W, He X.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):1008-1013. doi: 10.1016/j.bbrc.2017.11.134. Epub 2017 Nov 21.


Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression.

Hsu KW, Hsieh RH, Huang KH, Fen-Yau Li A, Chi CW, Wang TY, Tseng MJ, Wu KJ, Yeh TS.

Carcinogenesis. 2012 Aug;33(8):1459-67. doi: 10.1093/carcin/bgs165. Epub 2012 May 10.


Adipose tissues of MPC1± mice display altered lipid metabolism-related enzyme expression levels.

Zou S, Zhu L, Huang K, Luo H, Xu W, He X.

PeerJ. 2018 Oct 30;6:e5799. doi: 10.7717/peerj.5799. eCollection 2018.


Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer.

Huang Y, Yang M, Hu H, Zhao X, Bao L, Huang D, Song L, Li Y.

Oncotarget. 2016 Jul 5;7(27):41404-41420. doi: 10.18632/oncotarget.9167.


STAT3 activation in monocytes accelerates liver cancer progression.

Wu WY, Li J, Wu ZS, Zhang CL, Meng XL.

BMC Cancer. 2011 Dec 5;11:506. doi: 10.1186/1471-2407-11-506.


Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.

Bowman CE, Zhao L, Hartung T, Wolfgang MJ.

Mol Cell Biol. 2016 Jul 14;36(15):2089-104. doi: 10.1128/MCB.00166-16. Print 2016 Aug 1.


Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings.

Pan CM, Wang ML, Chiou SH, Chen HY, Wu CW.

Oncotarget. 2016 Sep 13;7(37):60395-60406. doi: 10.18632/oncotarget.10939.

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