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Items: 1 to 20 of 101

1.

MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma.

New M, Van Acker T, Sakamaki JI, Jiang M, Saunders RE, Long J, Wang VM, Behrens A, Cerveira J, Sudhakar P, Korcsmaros T, Jefferies HBJ, Ryan KM, Howell M, Tooze SA.

Cancer Res. 2019 Apr 15;79(8):1884-1898. doi: 10.1158/0008-5472.CAN-18-2553. Epub 2019 Feb 14.

PMID:
30765601
2.

Molecular Pathways Controlling Autophagy in Pancreatic Cancer.

New M, Van Acker T, Long JS, Sakamaki JI, Ryan KM, Tooze SA.

Front Oncol. 2017 Mar 3;7:28. doi: 10.3389/fonc.2017.00028. eCollection 2017. Review.

3.

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.

Wang YP, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK, Lei QY.

Mol Cell. 2016 Nov 17;64(4):673-687. doi: 10.1016/j.molcel.2016.09.028. Epub 2016 Nov 10.

4.

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma.

Xie Y, Zhu S, Zhong M, Yang M, Sun X, Liu J, Kroemer G, Lotze M, Zeh HJ 3rd, Kang R, Tang D.

Gastroenterology. 2017 Nov;153(5):1429-1443.e5. doi: 10.1053/j.gastro.2017.07.036. Epub 2017 Jul 29.

5.

The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.

Tactacan CM, Phua YW, Liu L, Zhang L, Humphrey ES, Cowley M, Pinese M, Biankin AV, Daly RJ.

Mol Cancer. 2015 Jul 29;14:139. doi: 10.1186/s12943-015-0412-3.

6.

LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis.

Huang F, Chen W, Peng J, Li Y, Zhuang Y, Zhu Z, Shao C, Yang W, Yao H, Zhang S.

Mol Cancer. 2018 Jul 12;17(1):98. doi: 10.1186/s12943-018-0845-6.

7.

Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition.

Li X, Roife D, Kang Y, Dai B, Pratt M, Fleming JB.

Oncogene. 2016 Sep 15;35(37):4881-90. doi: 10.1038/onc.2016.20. Epub 2016 Feb 15.

PMID:
26876211
8.

Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.

Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H.

Gastroenterology. 2019 Jan;156(1):203-217.e20. doi: 10.1053/j.gastro.2018.09.053. Epub 2018 Oct 6.

PMID:
30296435
9.

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, Wang P, Ma X, Kroemer G, Bartlett DL, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D.

Gastroenterology. 2018 Apr;154(5):1480-1493. doi: 10.1053/j.gastro.2017.12.004. Epub 2017 Dec 14.

10.

Inhibition of Survival Pathways MAPK and NF-kB Triggers Apoptosis in Pancreatic Ductal Adenocarcinoma Cells via Suppression of Autophagy.

Papademetrio DL, Lompardía SL, Simunovich T, Costantino S, Mihalez CY, Cavaliere V, Álvarez É.

Target Oncol. 2016 Apr;11(2):183-95. doi: 10.1007/s11523-015-0388-3.

PMID:
26373299
11.

Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness.

Rademaker G, Hennequière V, Brohée L, Nokin MJ, Lovinfosse P, Durieux F, Gofflot S, Bellier J, Costanza B, Herfs M, Peiffer R, Bettendorff L, Deroanne C, Thiry M, Delvenne P, Hustinx R, Bellahcène A, Castronovo V, Peulen O.

Oncogene. 2018 Aug;37(32):4398-4412. doi: 10.1038/s41388-018-0287-z. Epub 2018 May 3.

12.

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine.

Fiorini C, Cordani M, Padroni C, Blandino G, Di Agostino S, Donadelli M.

Biochim Biophys Acta. 2015 Jan;1853(1):89-100. doi: 10.1016/j.bbamcr.2014.10.003. Epub 2014 Oct 13.

13.

p53 status determines the role of autophagy in pancreatic tumour development.

Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM.

Nature. 2013 Dec 12;504(7479):296-300. doi: 10.1038/nature12865. Epub 2013 Dec 4.

PMID:
24305049
14.

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma.

Zhang W, Nandakumar N, Shi Y, Manzano M, Smith A, Graham G, Gupta S, Vietsch EE, Laughlin SZ, Wadhwa M, Chetram M, Joshi M, Wang F, Kallakury B, Toretsky J, Wellstein A, Yi C.

Sci Signal. 2014 May 6;7(324):ra42. doi: 10.1126/scisignal.2005049.

15.

MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway.

Sun L, Hu L, Cogdell D, Lu L, Gao C, Tian W, Zhang Z, Kang Y, Fleming JB, Zhang W.

Autophagy. 2017 Apr 3;13(4):703-714. doi: 10.1080/15548627.2017.1280217. Epub 2017 Jan 25.

16.

Role of TFEB-driven autophagy regulation in pancreatic cancer treatment.

Klein K, Werner K, Teske C, Schenk M, Giese T, Weitz J, Welsch T.

Int J Oncol. 2016 Jul;49(1):164-72. doi: 10.3892/ijo.2016.3505. Epub 2016 May 5.

PMID:
27175909
17.

The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.

Donohue E, Thomas A, Maurer N, Manisali I, Zeisser-Labouebe M, Zisman N, Anderson HJ, Ng SS, Webb M, Bally M, Roberge M.

J Cancer. 2013 Aug 28;4(7):585-96. doi: 10.7150/jca.7030. eCollection 2013.

18.

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.

Gruber R, Panayiotou R, Nye E, Spencer-Dene B, Stamp G, Behrens A.

Gastroenterology. 2016 Sep;151(3):526-39. doi: 10.1053/j.gastro.2016.05.006. Epub 2016 May 20.

19.

Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status.

Yang A, Kimmelman AC.

Autophagy. 2014 Sep;10(9):1683-4. doi: 10.4161/auto.29961. Epub 2014 Jul 17.

20.

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer.

Thakur PC, Miller-Ocuin JL, Nguyen K, Matsuda R, Singhi AD, Zeh HJ, Bahary N.

J Transl Med. 2018 Jul 9;16(1):190. doi: 10.1186/s12967-018-1562-z.

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