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Items: 1 to 20 of 99

1.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

2.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
3.

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

Brownfoot FC, Hastie R, Hannan NJ, Cannon P, Tuohey L, Parry LJ, Senadheera S, Illanes SE, Kaitu'u-Lino TJ, Tong S.

Am J Obstet Gynecol. 2016 Mar;214(3):356.e1-356.e15. doi: 10.1016/j.ajog.2015.12.019. Epub 2015 Dec 22.

PMID:
26721779
4.

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release.

Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, Lu Y, Li K, Niu H, Lee KH, Huang W.

Sci Rep. 2016 Nov 2;6:36222. doi: 10.1038/srep36222.

5.

Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.

Velez J, Pan R, Lee JT, Enciso L, Suarez M, Duque JE, Jaramillo D, Lopez C, Morales L, Bornmann W, Konopleva M, Krystal G, Andreeff M, Samudio I.

Oncotarget. 2016 Aug 9;7(32):51435-51449. doi: 10.18632/oncotarget.9843.

6.

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.

Br J Pharmacol. 2007 Apr;150(8):1031-43. Epub 2007 Mar 5.

7.

Ambient air pollution and thrombosis.

Robertson S, Miller MR.

Part Fibre Toxicol. 2018 Jan 3;15(1):1. doi: 10.1186/s12989-017-0237-x. Review.

8.

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F.

Sci Rep. 2017 Jul 11;7(1):5040. doi: 10.1038/s41598-017-05052-2.

9.

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.

Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS.

Elife. 2014 May 13;3:e02242. doi: 10.7554/eLife.02242.

10.

Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure.

Winckelmans E, Nawrot TS, Tsamou M, Den Hond E, Baeyens W, Kleinjans J, Lefebvre W, Van Larebeke N, Peusens M, Plusquin M, Reynders H, Schoeters G, Vanpoucke C, de Kok TM, Vrijens K.

Environ Health. 2017 Aug 18;16(1):87. doi: 10.1186/s12940-017-0292-7.

11.

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.

Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR.

J Biol Chem. 2009 Jan 23;284(4):2176-86. doi: 10.1074/jbc.M808844200. Epub 2008 Nov 25.

12.

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration.

Larsen S, Rabøl R, Hansen CN, Madsbad S, Helge JW, Dela F.

Diabetologia. 2012 Feb;55(2):443-9. doi: 10.1007/s00125-011-2340-0. Epub 2011 Oct 19.

PMID:
22009334
13.

Air pollution and venous thrombosis: a meta-analysis.

Tang L, Wang QY, Cheng ZP, Hu B, Liu JD, Hu Y.

Sci Rep. 2016 Sep 7;6:32794. doi: 10.1038/srep32794.

14.

SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.

Wu Y, Gao WN, Xue YN, Zhang LC, Zhang JJ, Lu SY, Yan XY, Yu HM, Su J, Sun LK.

Exp Cell Res. 2018 Jun 15;367(2):137-149. doi: 10.1016/j.yexcr.2018.03.030. Epub 2018 Mar 23.

PMID:
29580688
15.

Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.

Buler M, Aatsinki SM, Izzi V, Hakkola J.

PLoS One. 2012;7(11):e49863. doi: 10.1371/journal.pone.0049863. Epub 2012 Nov 16.

16.

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study.

Guigas B, Detaille D, Chauvin C, Batandier C, De Oliveira F, Fontaine E, Leverve X.

Biochem J. 2004 Sep 15;382(Pt 3):877-84.

17.

Metformin and Breast Cancer: Molecular Targets.

Faria J, Negalha G, Azevedo A, Martel F.

J Mammary Gland Biol Neoplasia. 2019 Mar 22. doi: 10.1007/s10911-019-09429-z. [Epub ahead of print] Review.

PMID:
30903363
18.

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation.

Kim KH, Jeong YT, Kim SH, Jung HS, Park KS, Lee HY, Lee MS.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):76-81. doi: 10.1016/j.bbrc.2013.09.026. Epub 2013 Sep 13.

PMID:
24041694
19.

Fibrin clot structure is affected by levels of particulate air pollution exposure in patients with venous thrombosis.

Pan X, Gong YY, Martinelli I, Angelici L, Favero C, Bertazzi PA, Mannucci PM, Ariëns RA, Routledge MN.

Environ Int. 2016 Jul-Aug;92-93:70-6. doi: 10.1016/j.envint.2016.03.030. Epub 2016 Apr 7.

20.

Metformin selectively targets redox control of complex I energy transduction.

Cameron AR, Logie L, Patel K, Erhardt S, Bacon S, Middleton P, Harthill J, Forteath C, Coats JT, Kerr C, Curry H, Stewart D, Sakamoto K, Repiščák P, Paterson MJ, Hassinen I, McDougall G, Rena G.

Redox Biol. 2018 Apr;14:187-197. doi: 10.1016/j.redox.2017.08.018. Epub 2017 Aug 26.

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