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Pulse Pressure, Cardiovascular Events, and Intensive Blood-Pressure Lowering in the Systolic Blood Pressure Intervention Trial (SPRINT).

Pareek M, Vaduganathan M, Biering-Sørensen T, Byrne C, Qamar A, Almarzooq Z, Pandey A, Olsen MH, Bhatt DL.

Am J Med. 2019 Jan 16. pii: S0002-9343(19)30060-9. doi: 10.1016/j.amjmed.2019.01.001. [Epub ahead of print]


Body Mass Index, Intensive Blood Pressure Management, and Cardiovascular Events in the SPRINT Trial.

Oxlund CS, Pareek M, Rasmussen BSB, Vaduganathan M, Biering-Sørensen T, Byrne C, Almarzooq Z, Olsen MH, Bhatt DL.

Am J Med. 2019 Feb 2. pii: S0002-9343(19)30133-0. doi: 10.1016/j.amjmed.2019.01.024. [Epub ahead of print]


Assessment of Risk of Harm Associated With Intensive Blood Pressure Management Among Patients With Hypertension Who Smoke: A Secondary Analysis of the Systolic Blood Pressure Intervention Trial.

Scarpa J, Bruzelius E, Doupe P, Le M, Faghmous J, Baum A.

JAMA Netw Open. 2019 Mar 1;2(3):e190005. doi: 10.1001/jamanetworkopen.2019.0005.


Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.

Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, Woodward M, MacMahon S, Turnbull F, Hillis GS, Chalmers J, Mant J, Salam A, Rahimi K, Perkovic V, Rodgers A.

Lancet. 2016 Jan 30;387(10017):435-43. doi: 10.1016/S0140-6736(15)00805-3. Epub 2015 Nov 7. Review.


Diastolic Hypotension May Attenuate Benefits from Intensive Systolic Targets: Secondary Analysis of a Randomized Controlled Trial.

Lee TC, Cavalcanti RB, McDonald EG, Pilote L, Brophy JM.

Am J Med. 2018 Oct;131(10):1228-1233.e1. doi: 10.1016/j.amjmed.2018.05.022. Epub 2018 Jun 12.


Effects of Intensive Systolic Blood Pressure Lowering on Cardiovascular Events and Mortality in Patients With Type 2 Diabetes Mellitus on Standard Glycemic Control and in Those Without Diabetes Mellitus: Reconciling Results From ACCORD BP and SPRINT.

Beddhu S, Chertow GM, Greene T, Whelton PK, Ambrosius WT, Cheung AK, Cutler J, Fine L, Boucher R, Wei G, Zhang C, Kramer H, Bress AP, Kimmel PL, Oparil S, Lewis CE, Rahman M, Cushman WC.

J Am Heart Assoc. 2018 Sep 18;7(18):e009326. doi: 10.1161/JAHA.118.009326.


Benefit and harm of intensive blood pressure treatment: Derivation and validation of risk models using data from the SPRINT and ACCORD trials.

Basu S, Sussman JB, Rigdon J, Steimle L, Denton BT, Hayward RA.

PLoS Med. 2017 Oct 17;14(10):e1002410. doi: 10.1371/journal.pmed.1002410. eCollection 2017 Oct.


Effect of Lowering Diastolic Pressure in Patients With and Without Cardiovascular Disease: Analysis of the SPRINT (Systolic Blood Pressure Intervention Trial).

Khan NA, Rabkin SW, Zhao Y, McAlister FA, Park JE, Guan M, Chan S, Humphries KH.

Hypertension. 2018 May;71(5):840-847. doi: 10.1161/HYPERTENSIONAHA.117.10177. Epub 2018 Mar 26.


Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials.

Beddhu S, Greene T, Boucher R, Cushman WC, Wei G, Stoddard G, Ix JH, Chonchol M, Kramer H, Cheung AK, Kimmel PL, Whelton PK, Chertow GM.

Lancet Diabetes Endocrinol. 2018 Jul;6(7):555-563. doi: 10.1016/S2213-8587(18)30099-8. Epub 2018 Apr 21.


Potential Deaths Averted and Serious Adverse Events Incurred From Adoption of the SPRINT (Systolic Blood Pressure Intervention Trial) Intensive Blood Pressure Regimen in the United States: Projections From NHANES (National Health and Nutrition Examination Survey).

Bress AP, Kramer H, Khatib R, Beddhu S, Cheung AK, Hess R, Bansal VK, Cao G, Yee J, Moran AE, Durazo-Arvizu R, Muntner P, Cooper RS.

Circulation. 2017 Apr 25;135(17):1617-1628. doi: 10.1161/CIRCULATIONAHA.116.025322. Epub 2017 Feb 13.


Intensive Blood Pressure Lowering in Patients With and Patients Without Type 2 Diabetes: A Pooled Analysis From Two Randomized Trials.

Brouwer TF, Vehmeijer JT, Kalkman DN, Berger WR, van den Born BH, Peters RJ, Knops RE.

Diabetes Care. 2018 Jun;41(6):1142-1148. doi: 10.2337/dc17-1722. Epub 2017 Dec 6.


The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT).

Ambrosius WT, Sink KM, Foy CG, Berlowitz DR, Cheung AK, Cushman WC, Fine LJ, Goff DC Jr, Johnson KC, Killeen AA, Lewis CE, Oparil S, Reboussin DM, Rocco MV, Snyder JK, Williamson JD, Wright JT Jr, Whelton PK; SPRINT Study Research Group.

Clin Trials. 2014 Oct;11(5):532-46. doi: 10.1177/1740774514537404. Epub 2014 Jun 5. Erratum in: Clin Trials. 2017 Apr;14(2):222.


Lowering systolic blood pressure does not increase stroke risk: an analysis of the SPRINT and ACCORD trial data.

O'Conor EC, Wang J, Gibney KD, Yu X, Young GR, Jones T, Alexandrov AW, Johnson KC, Cushman WC, Tsao JW.

Ann Clin Transl Neurol. 2018 Nov 28;6(1):144-153. doi: 10.1002/acn3.693. eCollection 2019 Jan.


Personalizing the Intensity of Blood Pressure Control: Modeling the Heterogeneity of Risks and Benefits From SPRINT (Systolic Blood Pressure Intervention Trial).

Patel KK, Arnold SV, Chan PS, Tang Y, Pokharel Y, Jones PG, Spertus JA.

Circ Cardiovasc Qual Outcomes. 2017 Apr;10(4). pii: e003624. doi: 10.1161/CIRCOUTCOMES.117.003624.


Effect of intensive blood pressure lowering on cardiovascular outcomes based on cardiovascular risk: A secondary analysis of the SPRINT trial.

Attar A, Sayadi M, Jannati M.

Eur J Prev Cardiol. 2019 Feb;26(3):238-245. doi: 10.1177/2047487318800741. Epub 2018 Sep 26.


A Randomized Trial of Intensive versus Standard Blood-Pressure Control.

SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT.

N Engl J Med. 2015 Nov 26;373(22):2103-16. doi: 10.1056/NEJMoa1511939. Epub 2015 Nov 9. Erratum in: N Engl J Med. 2017 Dec 21;377(25):2506.


Influence of baseline systolic blood pressure on the relationship between intensive blood pressure control and cardiovascular outcomes in the Systolic Blood Pressure Intervention Trial (SPRINT).

Sun X, Guo Y, Nie Z, Cheng J, Zhou H, Zhong X, Zhang S, Du Z, Zhuang X, Liao X.

Clin Res Cardiol. 2019 Mar;108(3):273-281. doi: 10.1007/s00392-018-1353-9. Epub 2018 Aug 24.


Clinical Outcomes by Race and Ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT): A Randomized Clinical Trial.

Still CH, Rodriguez CJ, Wright JT Jr, Craven TE, Bress AP, Chertow GM, Whelton PK, Whittle JC, Freedman BI, Johnson KC, Foy CG, He J, Kostis JB, Lash JP, Pedley CF, Pisoni R, Powell JR, Wall BM; SPRINT Writing Group.

Am J Hypertens. 2017 Dec 8;31(1):97-107. doi: 10.1093/ajh/hpx138.


Systolic Blood Pressure Intervention Trial (SPRINT) and Target Systolic Blood Pressure in Future Hypertension Guidelines.

Egan BM, Li J, Wagner CS.

Hypertension. 2016 Aug;68(2):318-23. doi: 10.1161/HYPERTENSIONAHA.116.07575. Epub 2016 Jun 27.


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