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Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition.

Muñoz-Martín N, Sierra R, Schimmang T, Villa Del Campo C, Torres M.

Development. 2019 Feb 1;146(3). pii: dev170753. doi: 10.1242/dev.170753.


Myocardial Mycn is essential for mouse ventricular wall morphogenesis.

Harmelink C, Peng Y, DeBenedittis P, Chen H, Shou W, Jiao K.

Dev Biol. 2013 Jan 1;373(1):53-63. doi: 10.1016/j.ydbio.2012.10.005. Epub 2012 Oct 12.


Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart.

Villa Del Campo C, Clavería C, Sierra R, Torres M.

Cell Rep. 2014 Sep 25;8(6):1741-1751. doi: 10.1016/j.celrep.2014.08.005. Epub 2014 Sep 4.


Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.

Kramer M, Ribeiro D, Arsenian-Henriksson M, Deller T, Rohrer H.

J Neurosci. 2016 Oct 5;36(40):10425-10439.


Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.

Lee HG, Chen Q, Wolfram JA, Richardson SL, Liner A, Siedlak SL, Zhu X, Ziats NP, Fujioka H, Felsher DW, Castellani RJ, Valencik ML, McDonald JA, Hoit BD, Lesnefsky EJ, Smith MA.

PLoS One. 2009 Sep 25;4(9):e7172. doi: 10.1371/journal.pone.0007172.


The MYCN oncoprotein as a drug development target.

Lu X, Pearson A, Lunec J.

Cancer Lett. 2003 Jul 18;197(1-2):125-30. Review.


MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas.

Huang R, Cheung NK, Vider J, Cheung IY, Gerald WL, Tickoo SK, Holland EC, Blasberg RG.

FASEB J. 2011 Dec;25(12):4138-49. doi: 10.1096/fj.11-185033. Epub 2011 Aug 19.


Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription.

Murray TV, Smyrnias I, Schnelle M, Mistry RK, Zhang M, Beretta M, Martin D, Anilkumar N, de Silva SM, Shah AM, Brewer AC.

J Mol Cell Cardiol. 2015 Feb;79:54-68. doi: 10.1016/j.yjmcc.2014.10.017. Epub 2014 Nov 6.


Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population.

Villa Del Campo C, Lioux G, Carmona R, Sierra R, Muñoz-Chápuli R, Clavería C, Torres M.

Sci Rep. 2016 Oct 18;6:35366. doi: 10.1038/srep35366. Erratum in: Sci Rep. 2016 Dec 09;6:37880.


Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A.

Stem Cells. 2015 Apr;33(4):1113-29. doi: 10.1002/stem.1923.


N-Myc differentially regulates expression of MXI1 isoforms in neuroblastoma.

Armstrong MB, Mody RJ, Ellis DC, Hill AB, Erichsen DA, Wechsler DS.

Neoplasia. 2013 Dec;15(12):1363-70.


Targeting of the MYCN protein with small molecule c-MYC inhibitors.

Müller I, Larsson K, Frenzel A, Oliynyk G, Zirath H, Prochownik EV, Westwood NJ, Henriksson MA.

PLoS One. 2014 May 23;9(5):e97285. doi: 10.1371/journal.pone.0097285. eCollection 2014.


BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.

Willis MS, Holley DW, Wang Z, Chen X, Quintana M, Jensen BC, Tannu M, Parker J, Jeyaraj D, Jain MK, Wolfram JA, Lee HG, Bultman SJ.

J Mol Cell Cardiol. 2017 Apr;105:99-109. doi: 10.1016/j.yjmcc.2017.02.003. Epub 2017 Feb 21.


Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo.

Chakraborty S, Yutzey KE.

Dev Biol. 2012 Mar 1;363(1):234-46. doi: 10.1016/j.ydbio.2011.12.034. Epub 2011 Dec 29.


Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells.

Cetinkaya C, Hultquist A, Su Y, Wu S, Bahram F, Påhlman S, Guzhova I, Larsson LG.

Mol Cancer Ther. 2007 Oct;6(10):2634-41.


A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.

Singh BN, Koyano-Nakagawa N, Gong W, Moskowitz IP, Weaver CV, Braunlin E, Das S, van Berlo JH, Garry MG, Garry DJ.

Nat Commun. 2018 Oct 12;9(1):4237. doi: 10.1038/s41467-018-06617-z.


Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group.

Wang LL, Suganuma R, Ikegaki N, Tang X, Naranjo A, McGrady P, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Shimada H.

Cancer. 2013 Oct 15;119(20):3718-26. doi: 10.1002/cncr.28251. Epub 2013 Jul 30.


Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells.

Chayka O, D'Acunto CW, Middleton O, Arab M, Sala A.

J Biol Chem. 2015 Jan 23;290(4):2198-212. doi: 10.1074/jbc.M114.624056. Epub 2014 Dec 4.


MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21.

Liu L, Xu F, Chang CK, He Q, Wu LY, Zhang Z, Li X.

Cell Death Dis. 2017 Oct 12;8(10):e3126. doi: 10.1038/cddis.2017.526.

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